Gene Review:
Mecp2 - methyl CpG binding protein 2
Mus musculus
Synonyms:
1500041B07Rik, BB130002, D630021H01Rik, Mbd5, MeCp-2 protein, ...
- Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome. Kriaucionis, S., Paterson, A., Curtis, J., Guy, J., Macleod, N., Bird, A. Mol. Cell. Biol. (2006)
- Separate respiratory phenotypes in methyl-CpG-binding protein 2 (Mecp2) deficient mice. Bissonnette, J.M., Knopp, S.J. Pediatr. Res. (2006)
- Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing. Harikrishnan, K.N., Chow, M.Z., Baker, E.K., Pal, S., Bassal, S., Brasacchio, D., Wang, L., Craig, J.M., Jones, P.L., Sif, S., El-Osta, A. Nat. Genet. (2005)
- An altered neonatal behavioral phenotype in Mecp2 mutant mice. Picker, J.D., Yang, R., Ricceri, L., Berger-Sweeney, J. Neuroreport (2006)
- Delayed maturation of neuronal architecture and synaptogenesis in cerebral cortex of Mecp2-deficient mice. Fukuda, T., Itoh, M., Ichikawa, T., Washiyama, K., Goto, Y. J. Neuropathol. Exp. Neurol. (2005)
- Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation. Shahbazian, M.D., Antalffy, B., Armstrong, D.L., Zoghbi, H.Y. Hum. Mol. Genet. (2002)
- MeCP2 dysfunction in humans and mice. Zoghbi, H.Y. J. Child Neurol. (2005)
- REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Ballas, N., Grunseich, C., Lu, D.D., Speh, J.C., Mandel, G. Cell (2005)
- A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Guy, J., Hendrich, B., Holmes, M., Martin, J.E., Bird, A. Nat. Genet. (2001)
- Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Chen, R.Z., Akbarian, S., Tudor, M., Jaenisch, R. Nat. Genet. (2001)
- Serotonin transporter abnormality in the dorsal motor nucleus of the vagus in Rett syndrome: potential implications for clinical autonomic dysfunction. Paterson, D.S., Thompson, E.G., Belliveau, R.A., Antalffy, B.A., Trachtenberg, F.L., Armstrong, D.D., Kinney, H.C. J. Neuropathol. Exp. Neurol. (2005)
- Increased dendritic complexity and axonal length in cultured mouse cortical neurons overexpressing methyl-CpG-binding protein MeCP2. Jugloff, D.G., Jung, B.P., Purushotham, D., Logan, R., Eubanks, J.H. Neurobiol. Dis. (2005)
- Genetic and physical mapping of a gene encoding a methyl CpG binding protein, Mecp2, to the mouse X chromosome. Quaderi, N.A., Meehan, R.R., Tate, P.H., Cross, S.H., Bird, A.P., Chatterjee, A., Herman, G.E., Brown, S.D. Genomics (1994)
- Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions. Reichwald, K., Thiesen, J., Wiehe, T., Weitzel, J., Poustka, W.A., Rosenthal, A., Platzer, M., Strätling, W.H., Kioschis, P. Mamm. Genome (2000)
- Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice. Viemari, J.C., Roux, J.C., Tryba, A.K., Saywell, V., Burnet, H., Peña, F., Zanella, S., Bévengut, M., Barthelemy-Requin, M., Herzing, L.B., Moncla, A., Mancini, J., Ramirez, J.M., Villard, L., Hilaire, G. J. Neurosci. (2005)
- Dysregulation of brain-derived neurotrophic factor expression and neurosecretory function in Mecp2 null mice. Wang, H., Chan, S.A., Ogier, M., Hellard, D., Wang, Q., Smith, C., Katz, D.M. J. Neurosci. (2006)
- A complex pattern of evolutionary conservation and alternative polyadenylation within the long 3"-untranslated region of the methyl-CpG-binding protein 2 gene (MeCP2) suggests a regulatory role in gene expression. Coy, J.F., Sedlacek, Z., Bächner, D., Delius, H., Poustka, A. Hum. Mol. Genet. (1999)
- A segment of the Mecp2 promoter is sufficient to drive expression in neurons. Adachi, M., Keefer, E.W., Jones, F.S. Hum. Mol. Genet. (2005)
- Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure. Ghoshal, K., Datta, J., Majumder, S., Bai, S., Dong, X., Parthun, M., Jacob, S.T. Mol. Cell. Biol. (2002)
- The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. Fuks, F., Hurd, P.J., Wolf, D., Nan, X., Bird, A.P., Kouzarides, T. J. Biol. Chem. (2003)
- FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands. Bedford, M.T., Chan, D.C., Leder, P. EMBO J. (1997)
- Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2. Nan, X., Meehan, R.R., Bird, A. Nucleic Acids Res. (1993)
- Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome. Nuber, U.A., Kriaucionis, S., Roloff, T.C., Guy, J., Selfridge, J., Steinhoff, C., Schulz, R., Lipkowitz, B., Ropers, H.H., Holmes, M.C., Bird, A. Hum. Mol. Genet. (2005)
- Methyl CpG-binding proteins induce large-scale chromatin reorganization during terminal differentiation. Brero, A., Easwaran, H.P., Nowak, D., Grunewald, I., Cremer, T., Leonhardt, H., Cardoso, M.C. J. Cell Biol. (2005)
- Reduced proportion of Purkinje cells expressing paternally derived mutant Mecp2308 allele in female mouse cerebellum is not due to a skewed primary pattern of X-chromosome inactivation. Watson, C.M., Pelka, G.J., Radziewic, T., Shahbazian, M.D., Christodoulou, J., Williamson, S.L., Tam, P.P. Hum. Mol. Genet. (2005)
- The transcriptional repressor Mecp2 regulates terminal neuronal differentiation. Matarazzo, V., Cohen, D., Palmer, A.M., Simpson, P.J., Khokhar, B., Pan, S.J., Ronnett, G.V. Mol. Cell. Neurosci. (2004)
- Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Marin, M., Karis, A., Visser, P., Grosveld, F., Philipsen, S. Cell (1997)
- Ube3a expression is not altered in Mecp2 mutant mice. Jordan, C., Francke, U. Hum. Mol. Genet. (2006)
- Distinct expression profiles of Mecp2 transcripts with different lengths of 3'UTR in the brain and visceral organs during mouse development. Pelka, G.J., Watson, C.M., Christodoulou, J., Tam, P.P. Genomics (2005)
- Defect in normal developmental increase of the brain biogenic amine concentrations in the mecp2-null mouse. Ide, S., Itoh, M., Goto, Y. Neurosci. Lett. (2005)
- Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome. Peddada, S., Yasui, D.H., LaSalle, J.M. Hum. Mol. Genet. (2006)