Gene Review:
Mef2c - myocyte enhancer factor 2C
Mus musculus
Synonyms:
5430401D19Rik, 9930028G15Rik, AV011172, Mef2, Myocyte-specific enhancer factor 2C
- Marked reduction of focal adhesion kinase, serum response factor and myocyte enhancer factor 2C, but increase in RhoA and myostatin in the hindlimb dy mouse muscles. Sakuma, K., Nakao, R., Inashima, S., Hirata, M., Kubo, T., Yasuhara, M. Acta Neuropathol. (2004)
- High level expression in soluble form, one step purification, and characterization of the DNA binding domain of MEF-2C. Meierhans, D., Allemann, R.K. Protein Expr. Purif. (1997)
- Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Nakagawa, O., Arnold, M., Nakagawa, M., Hamada, H., Shelton, J.M., Kusano, H., Harris, T.M., Childs, G., Campbell, K.P., Richardson, J.A., Nishino, I., Olson, E.N. Genes Dev. (2005)
- Targeted inhibition of Ca2+/calmodulin signaling exacerbates the dystrophic phenotype in mdx mouse muscle. Chakkalakal, J.V., Michel, S.A., Chin, E.R., Michel, R.N., Jasmin, B.J. Hum. Mol. Genet. (2006)
- Phosphorylation and alternative pre-mRNA splicing converge to regulate myocyte enhancer factor 2C activity. Zhu, B., Gulick, T. Mol. Cell. Biol. (2004)
- A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing. Martin, J.F., Miano, J.M., Hustad, C.M., Copeland, N.G., Jenkins, N.A., Olson, E.N. Mol. Cell. Biol. (1994)
- Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Takeuchi, J.K., Mileikovskaia, M., Koshiba-Takeuchi, K., Heidt, A.B., Mori, A.D., Arruda, E.P., Gertsenstein, M., Georges, R., Davidson, L., Mo, R., Hui, C.C., Henkelman, R.M., Nemer, M., Black, B.L., Nagy, A., Bruneau, B.G. Development (2005)
- Generation of conditional Mef2cloxP/loxP mice for temporal- and tissue-specific analyses. Vong, L.H., Ragusa, M.J., Schwarz, J.J. Genesis (2005)
- Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development. Dodou, E., Verzi, M.P., Anderson, J.P., Xu, S.M., Black, B.L. Development (2004)
- The Mef2c gene is a direct transcriptional target of myogenic bHLH and MEF2 proteins during skeletal muscle development. Wang, D.Z., Valdez, M.R., McAnally, J., Richardson, J., Olson, E.N. Development (2001)
- Mef2c is activated directly by Ets transcription factors through an evolutionarily conserved endothelial cell-specific enhancer. De Val, S., Anderson, J.P., Heidt, A.B., Khiem, D., Xu, S.M., Black, B.L. Dev. Biol. (2004)
- Foxh1 is essential for development of the anterior heart field. von Both, I., Silvestri, C., Erdemir, T., Lickert, H., Walls, J.R., Henkelman, R.M., Rossant, J., Harvey, R.P., Attisano, L., Wrana, J.L. Dev. Cell (2004)
- p38 MAP kinase signalling is required for hypertrophic chondrocyte differentiation. Stanton, L.A., Sabari, S., Sampaio, A.V., Underhill, T.M., Beier, F. Biochem. J. (2004)
- Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress. Illi, B., Scopece, A., Nanni, S., Farsetti, A., Morgante, L., Biglioli, P., Capogrossi, M.C., Gaetano, C. Circ. Res. (2005)
- The coactivator-associated arginine methyltransferase is necessary for muscle differentiation: CARM1 coactivates myocyte enhancer factor-2. Chen, S.L., Loffler, K.A., Chen, D., Stallcup, M.R., Muscat, G.E. J. Biol. Chem. (2002)
- BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart. Phan, D., Rasmussen, T.L., Nakagawa, O., McAnally, J., Gottlieb, P.D., Tucker, P.W., Richardson, J.A., Bassel-Duby, R., Olson, E.N. Development (2005)
- Myocyte enhancer factor 2C and myogenin up-regulate each other's expression and induce the development of skeletal muscle in P19 cells. Ridgeway, A.G., Wilton, S., Skerjanc, I.S. J. Biol. Chem. (2000)
- Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha. Compernolle, V., Brusselmans, K., Franco, D., Moorman, A., Dewerchin, M., Collen, D., Carmeliet, P. Cardiovasc. Res. (2003)