Gene Review:
DLAT - dihydrolipoamide S-acetyltransferase
Homo sapiens
Synonyms:
70 kDa mitochondrial autoantigen of primary biliary cirrhosis, DLTA, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, M2 antigen complex 70 kDa subunit, ...
- Characterization of the autoantibody responses to recombinant E3 binding protein (protein X) of pyruvate dehydrogenase in primary biliary cirrhosis. Palmer, J.M., Jones, D.E., Quinn, J., McHugh, A., Yeaman, S.J. Hepatology (1999)
- In situ nucleic acid detection of PDC-E2, BCOADC-E2, OGDC-E2, PDC-E1alpha, BCOADC-E1alpha, OGDC-E1, and the E3 binding protein (protein X) in primary biliary cirrhosis. Harada, K., Sudo, Y., Kono, N., Ozaki, S., Tsuneyama, K., Gershwin, M.E., Nakanuma, Y. Hepatology (1999)
- Clinical significance of positive immunoblotting but negative immunofluorescence for antimitochondrial antibodies in patients with liver diseases other than primary biliary cirrhosis. Masuda, J., Omagar, K., Miyakawa, H., Hazama, H., Ohba, K., Kinoshita, H., Matsuo, I., Isomoto, H., Murata, I., Kohno, S. Autoimmunity (2002)
- Autoreactive responses to pyruvate dehydrogenase complex in the pathogenesis of primary biliary cirrhosis. Yeaman, S.J., Kirby, J.A., Jones, D.E. Immunol. Rev. (2000)
- Disease-specific cross-reactivity between mimicking peptides of heat shock protein of Mycobacterium gordonae and dominant epitope of E2 subunit of pyruvate dehydrogenase is common in Spanish but not British patients with primary biliary cirrhosis. Bogdanos, D.P., Pares, A., Baum, H., Caballeria, L., Rigopoulou, E.I., Ma, Y., Burroughs, A.K., Rodes, J., Vergani, D. J. Autoimmun. (2004)
- Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis. Bellucci, R., Oertelt, S., Gallagher, M., Li, S., Zorn, E., Weller, E., Porcheray, F., Alyea, E.P., Soiffer, R.J., Munshi, N.C., Gershwin, M.E., Ritz, J. Blood (2007)
- Carbohydrate-deficient transferrin and false-positive results for alcohol abuse in primary biliary cirrhosis: differential diagnosis by detection of mitochondrial autoantibodies. Bean, P., Sutphin, M.S., Liu, Y., Anton, R., Reynolds, T.B., Shoenfeld, Y., Peter, J.B. Clin. Chem. (1995)
- Impact of fatigue on the quality of life of patients with primary biliary cirrhosis. Huet, P.M., Deslauriers, J., Tran, A., Faucher, C., Charbonneau, J. Am. J. Gastroenterol. (2000)
- Structural features of envelope proteins on hepatitis C virus-like particles as determined by anti-envelope monoclonal antibodies and CD81 binding. Triyatni, M., Vergalla, J., Davis, A.R., Hadlock, K.G., Foung, S.K., Liang, T.J. Virology (2002)
- Anti-DNA antibody idiotypes in primary biliary cirrhosis. Schattner, A., Kaburaki, Y., Kaplan, M.M., Miller, K.B. Cell. Immunol. (1987)
- Carbohydrate-deficient transferrin, a marker for chronic alcohol consumption in different ethnic populations. Behrens, U.J., Worner, T.M., Braly, L.F., Schaffner, F., Lieber, C.S. Alcohol. Clin. Exp. Res. (1988)
- Detection of autoantibodies to recombinant mitochondrial proteins in patients with primary biliary cirrhosis. Van de Water, J., Cooper, A., Surh, C.D., Coppel, R., Danner, D., Ansari, A., Dickson, R., Gershwin, M.E. N. Engl. J. Med. (1989)
- Activation of gene expression by adenovirus and herpesvirus regulatory genes acting in trans and by a cis-acting adenovirus enhancer element. Imperiale, M.J., Feldman, L.T., Nevins, J.R. Cell (1983)
- Bovine papillomavirus E2 trans-activating gene product binds to specific sites in papillomavirus DNA. Androphy, E.J., Lowy, D.R., Schiller, J.T. Nature (1987)
- Chromosome localization and RFLP analysis of PDC-E2: the major autoantigen of primary biliary cirrhosis. Leung, P.S., Watanabe, Y., Munoz, S., Teuber, S.S., Patel, M.S., Korenberg, J.R., Hara, P., Coppel, R., Gershwin, M.E. Autoimmunity (1993)
- Mobile sequences in the pyruvate dehydrogenase complex, the E2 component, the catalytic domain and the 2-oxoglutarate dehydrogenase complex of Azotobacter vinelandii, as detected by 600 MHz 1H-NMR spectroscopy. Hanemaaijer, R., Vervoort, J., Westphal, A.H., de Kok, A., Veeger, C. FEBS Lett. (1988)
- Autoantibodies from patients with primary biliary cirrhosis recognize a restricted region within the cytoplasmic tail of nuclear pore membrane glycoprotein Gp210. Nickowitz, R.E., Worman, H.J. J. Exp. Med. (1993)
- The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis. Corpechot, C., Carrat, F., Bahr, A., Chrétien, Y., Poupon, R.E., Poupon, R. Gastroenterology (2005)
- Facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase. Hiromasa, Y., Roche, T.E. J. Biol. Chem. (2003)
- Fine specificity of T cells reactive to human PDC-E2 163-176 peptide, the immunodominant autoantigen in primary biliary cirrhosis: implications for molecular mimicry and cross-recognition among mitochondrial autoantigens. Shigematsu, H., Shimoda, S., Nakamura, M., Matsushita, S., Nishimura, Y., Sakamoto, N., Ichiki, Y., Niho, Y., Gershwin, M.E., Ishibashi, H. Hepatology (2000)
- Comprehensive mapping of HLA-A0201-restricted CD8 T-cell epitopes on PDC-E2 in primary biliary cirrhosis. Matsumura, S., Kita, H., He, X.S., Ansari, A.A., Lian, Z.X., Van De Water, J., Yamamoto, K., Tsuji, T., Coppel, R.L., Kaplan, M., Gershwin, M.E. Hepatology (2002)
- Clinical and genetic spectrum of pyruvate dehydrogenase deficiency: dihydrolipoamide acetyltransferase (E2) deficiency. Head, R.A., Brown, R.M., Zolkipli, Z., Shahdadpuri, R., King, M.D., Clayton, P.T., Brown, G.K. Ann. Neurol. (2005)
- Biochemistry and autoimmune response to the 2-oxoacid dehydrogenase complexes in primary biliary cirrhosis. Bassendine, M.F., Jones, D.E., Yeaman, S.J. Semin. Liver Dis. (1997)
- T cell responses to the putative dominant autoepitope in primary biliary cirrhosis (PBC). Palmer, J.M., Diamond, A.G., Yeaman, S.J., Bassendine, M.F., Jones, D.E. Clin. Exp. Immunol. (1999)
- Marked differences between two isoforms of human pyruvate dehydrogenase kinase. Baker, J.C., Yan, X., Peng, T., Kasten, S., Roche, T.E. J. Biol. Chem. (2000)
- Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms. Roche, T.E., Baker, J.C., Yan, X., Hiromasa, Y., Gong, X., Peng, T., Dong, J., Turkan, A., Kasten, S.A. Prog. Nucleic Acid Res. Mol. Biol. (2001)
- Molecular biology of the human pyruvate dehydrogenase complex: structural aspects of the E2 and E3 components. Thekkumkara, T.J., Pons, G., Mitroo, S., Jentoft, J.E., Patel, M.S. Ann. N. Y. Acad. Sci. (1989)
- Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP. Bao, H., Kasten, S.A., Yan, X., Hiromasa, Y., Roche, T.E. Biochemistry (2004)
- Humoral and cellular immune responses to dihydrolipoamide dehydrogenase (E3): lack of specificity for primary biliary cirrhosis. Tanaka, H., Maeda, T., Onishi, S., Yamamoto, Y. Liver (1995)
- Primary biliary cirrhosis is characterized by IgG3 antibodies cross-reactive with the major mitochondrial autoepitope and its Lactobacillus mimic. Bogdanos, D.P., Baum, H., Okamoto, M., Montalto, P., Sharma, U.C., Rigopoulou, E.I., Vlachogiannakos, J., Ma, Y., Burroughs, A.K., Vergani, D. Hepatology (2005)
- Characterization of recombinant monoclonal IgA anti-PDC-E2 autoantibodies derived from patients with PBC. Fukushima, N., Nalbandian, G., Van De Water, J., White, K., Ansari, A.A., Leung, P., Kenny, T., Kamita, S.G., Hammock, B.D., Coppel, R.L., Stevenson, F., Ishibashi, H., Gershwin, M.E. Hepatology (2002)
- Deficiency of the pyruvate dehydrogenase component in pyruvate dehydrogenase complex-deficient human fibroblasts. Immunological identification. Ho, L., Hu, C.W., Packman, S., Patel, M.S. J. Clin. Invest. (1986)
- Molecular architecture of the pyruvate dehydrogenase complex: bridging the gap. Smolle, M., Lindsay, J.G. Biochem. Soc. Trans. (2006)
- Immunoglobulin gene usage and immunohistochemical characteristics of human monoclonal antibodies to the mitochondrial autoantigens of primary biliary cirrhosis induced in the XenoMouse. Sasaki, M., Van De Water, J., Kenny, T.P., Gallo, M.L., Leung, P.S., Nakanuma, Y., Ansari, A.A., Coppel, R.L., Neuberger, J., Gershwin, M.E. Hepatology (2001)
- Autoantigens in primary biliary cirrhosis. Jones, D.E. J. Clin. Pathol. (2000)