Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

cki-1 - CKI family (Cyclin-dependent Kinase...

Caenorhabditis elegans

Kostić, I., Kostić, I., Fukuyama, M., Boxem, M., Hong, Y., et al.

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High impact information on cki-1

Genetic interaction and transgene expression studies suggest that cdc-14 functions upstream of the cki-1 Cip/Kip inhibitor to promote accumulation of CKI-1 in the nucleus [1].
Loss of rnt-1 is correlated with upregulation of cki-1, a CDK inhibitor [2].
Loss of function of the C. elegans p27 homolog, cki-1, causes extra cell divisions in numerous tissues including the hypodermis, the vulva, and the intestine [3].
lin-35 Rb and cki-1 Cip/Kip cooperate in developmental regulation of G1 progression in C. elegans [4].
We suggest that a rate limiting role for cki-1 Cip/Kip rather than lin-35 Rb explains the lack of cell-cycle phenotype of lin-35 mutant animals [4].

Biological context of cki-1

Our findings demonstrate that cki-1 activity plays an essential role in embryonic cell cycle arrest, differentiation and morphogenesis, and suggest that it may be required to suppress programmed cell death or engulfment of cell corpses [5].
cki-1 links cell division and cell fate acquisition in the C. elegans somatic gonad [6].
Results from our laser microsurgery experiments suggest that the extra DTCs are caused by aberrant somatic gonadal precursor cell divisions in the absence of cki-1, resulting in abnormal daughter cell fates. cki-1(RNAi) animals also possess extra anchor cells and ectopic gonad arms with variable sheath cell numbers and positioning [6].
Surprisingly, loss of cki-1, but not lin-35, results in precocious entry into S phase [4].
Essential embryonic roles of the CKI-1 cyclin-dependent kinase inhibitor in cell-cycle exit and morphogenesis in C elegans [5].

Anatomical context of cki-1

In vulva precursor cells (VPCs), a pathway of heterochronic genes acts via cki-1 to maintain VPCs in G1 during the L2 stage [7].
We show that DAF-16 is required for transcription of the cyclin-dependent kinase inhibitor cki-1 in stem cells in response to starvation, accounting for the failure of daf-16/FOXO mutants to arrest cell division during L1 arrest [8].
These include defects in mitotic chromosomal condensation and segregation, pronuclear rotation, and germ cell proliferation, abnormal cortical protrusion, and accumulation of the cyclin-dependent kinase inhibitor CKI1 [9].

Associations of cki-1 with chemical compounds

ClC-2 currents attenuated by p34(cdc2)/cyclin B were increased by application of the cyclin-dependent kinase inhibitor, olomoucine (100 microM), an effect that was inhibited by calyculin A (5 nM) but not by okadaic acid (5 nM) [10].

Other interactions of cki-1

C. elegans cki-1 encodes a member of the CIP/KIP family of cyclin-dependent kinase inhibitors, and functions to link postembryonic developmental programs to cell cycle progression [7].

References

The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans. Saito, R.M., Perreault, A., Peach, B., Satterlee, J.S., van den Heuvel, S. Nat. Cell Biol. (2004)
mab-2 encodes RNT-1, a C. elegans Runx homologue essential for controlling cell proliferation in a stem cell-like developmental lineage. Nimmo, R., Antebi, A., Woollard, A. Development (2005)
Organ-specific cell division abnormalities caused by mutation in a general cell cycle regulator in C. elegans. Kostić, I., Roy, R. Development (2002)
lin-35 Rb and cki-1 Cip/Kip cooperate in developmental regulation of G1 progression in C. elegans. Boxem, M., van den Heuvel, S. Development (2001)
Essential embryonic roles of the CKI-1 cyclin-dependent kinase inhibitor in cell-cycle exit and morphogenesis in C elegans. Fukuyama, M., Gendreau, S.B., Derry, W.B., Rothman, J.H. Dev. Biol. (2003)
cki-1 links cell division and cell fate acquisition in the C. elegans somatic gonad. Kostić, I., Li, S., Roy, R. Dev. Biol. (2003)
Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegans. Hong, Y., Roy, R., Ambros, V. Development (1998)
DAF-16/FOXO regulates transcription of cki-1/Cip/Kip and repression of lin-4 during C. elegans L1 arrest. Baugh, L.R., Sternberg, P.W. Curr. Biol. (2006)
Caenorhabditis elegans Elongin BC complex is essential for cell proliferation and chromosome condensation and segregation during mitosis and meiotic division II. Sasagawa, Y., Kikuchi, K., Dazai, K., Higashitani, A. Chromosome Res. (2005)
Phosphorylation and functional regulation of ClC-2 chloride channels expressed in Xenopus oocytes by M cyclin-dependent protein kinase. Furukawa, T., Ogura, T., Zheng, Y.J., Tsuchiya, H., Nakaya, H., Katayama, Y., Inagaki, N. J. Physiol. (Lond.) (2002)