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Gene Review

unc-105  -  Protein UNC-105

Caenorhabditis elegans

 
 
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High impact information on unc-105

  • Genetic evidence was obtained that the unc-105 gene product represents a degenerin homolog affecting C. elegans muscles and that this putative channel interacts with type IV collagen in the extracellular matrix underlying the muscle cell [1].
  • In C. elegans muscle, the existence of a genetic interaction between the unc-105 degenerin gene and let-2, a gene encoding an alpha2(IV) collagen, raised the possibility that UNC-105 may function as a mechanically gated channel in a stretch receptor complex [2].
  • An inward current could be also activated by protons in a GABA receptor null mutant in the presence of D-tubocurare and in an unc-105 null mutant [3].
  • Most of the reversion events are intragenic, apparently because the null (loss-of-function) phenotype of unc-105 is wild type [4].
 

Other interactions of unc-105

  • Certain mutations in several degenerin genes cause the swelling, vacuolation, and death of neurons, and other mutations in the muscle degenerin gene unc-105 cause hypercontraction [5].

References

 
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