The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

DLX3  -  distal-less homeobox 3

Homo sapiens

Synonyms: AI4, Homeobox protein DLX-3, TDO
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of DLX3

 

High impact information on DLX3

  • In this paper we describe genomic cloning and sequencing of both human DLX3 and DLX7 and identification of a 4 bp deletion in human DLX3 which correlates with the TDO phenotype in six families [5].
  • Small interfering RNA knockdown studies in osteoblasts validate that DLX3 is a potent regulator of Runx2 [6].
  • Here we show that BMP2 induces DLX3, a homeodomain protein that activates Runx2 gene transcription [6].
  • Immunocytochemical and immunoprecipitation studies demonstrate overlapping nuclear localization and physical interaction between Dlx3 and Smad6 in human choriocarcinoma cells and in differentiated trophoblasts from human placenta [7].
  • Smad6 appears to play a modulatory role in the regulation of Dlx3-dependent gene transcription within placental trophoblasts [7].
 

Biological context of DLX3

 

Anatomical context of DLX3

  • A 5' deletion series of the Dlx3 promoter revealed that a 13-nucleotide CCAAT box-containing element was required for basal expression in choriocarcinoma cell lines [3].
  • As demonstrated for differentiation-specific granular markers, Dlx3 is activated in primary mouse keratinocytes cultured in vitro by increasing the level of the extracellular Ca(2+) [11].
  • Like in bone marrow-derived stem cells, DLX-3 gene expression was increased in dental follicle cells during osteogenic differentiation but similar to control cultures [12].
  • Second, we present evidence for a role for murine Dlx3 in the development of the branchial arches [13].
  • Dlx3 and p63 act as part of the transcriptional regulatory pathways relevant in ectoderm derivatives, and autosomal mutations in either of these genes are associated with human EDs [4].
 

Other interactions of DLX3

  • Recent reports involve kallikrein-4 (KLK4), MMP-20, and DLX3 genes in the etiologies of some cases [14].
  • Conclusive evidence for linkage of DGI was obtained to genetic markers on chromosome 17q21-q22 (DLX-3, Z(max) = 5.34, theta = 0.00) [15].
 

Analytical, diagnostic and therapeutic context of DLX3

References

  1. DLX genes as targets of ALL-1: DLX 2,3,4 down-regulation in t(4;11) acute lymphoblastic leukemias. Ferrari, N., Palmisano, G.L., Paleari, L., Basso, G., Mangioni, M., Fidanza, V., Albini, A., Croce, C.M., Levi, G., Brigati, C. J. Leukoc. Biol. (2003) [Pubmed]
  2. Transcriptional activation by the homeodomain protein distal-less 3. Feledy, J.A., Morasso, M.I., Jang, S.I., Sargent, T.D. Nucleic Acids Res. (1999) [Pubmed]
  3. A role for CCAAT/enhancer-binding protein beta in the basal regulation of the distal-less 3 gene promoter in placental cells. Holland, M.P., Bliss, S.P., Berghorn, K.A., Roberson, M.S. Endocrinology (2004) [Pubmed]
  4. Homeobox gene Dlx3 is regulated by p63 during ectoderm development: relevance in the pathogenesis of ectodermal dysplasias. Radoja, N., Guerrini, L., Lo Iacono, N., Merlo, G.R., Costanzo, A., Weinberg, W.C., La Mantia, G., Calabr??, V., Morasso, M.I. Development (2007) [Pubmed]
  5. Identification of a mutation in DLX3 associated with tricho-dento-osseous (TDO) syndrome. Price, J.A., Bowden, D.W., Wright, J.T., Pettenati, M.J., Hart, T.C. Hum. Mol. Genet. (1998) [Pubmed]
  6. BMP2 Commitment to the Osteogenic Lineage Involves Activation of Runx2 by DLX3 and a Homeodomain Transcriptional Network. Hassan, M.Q., Tare, R.S., Lee, S.H., Mandeville, M., Morasso, M.I., Javed, A., van Wijnen, A.J., Stein, J.L., Stein, G.S., Lian, J.B. J. Biol. Chem. (2006) [Pubmed]
  7. Smad6 represses Dlx3 transcriptional activity through inhibition of DNA binding. Berghorn, K.A., Clark-Campbell, P.A., Han, L., McGrattan, M., Weiss, R.S., Roberson, M.S. J. Biol. Chem. (2006) [Pubmed]
  8. Isolation and identification of homeobox genes from the human placenta including a novel member of the Distal-less family, DLX4. Quinn, L.M., Johnson, B.V., Nicholl, J., Sutherland, G.R., Kalionis, B. Gene (1997) [Pubmed]
  9. Increased bone density associated with DLX3 mutation in the tricho-dento-osseous syndrome. Haldeman, R.J., Cooper, L.F., Hart, T.C., Phillips, C., Boyd, C., Lester, G.E., Wright, J.T. Bone (2004) [Pubmed]
  10. DLX3 mutation associated with autosomal dominant amelogenesis imperfecta with taurodontism. Dong, J., Amor, D., Aldred, M.J., Gu, T., Escamilla, M., MacDougall, M. Am. J. Med. Genet. A (2005) [Pubmed]
  11. Phosphorylation of murine homeodomain protein Dlx3 by protein kinase C. Park, G.T., Denning, M.F., Morasso, M.I. FEBS Lett. (2001) [Pubmed]
  12. Gene expression of runx2, Osterix, c-fos, DLX-3, DLX-5, and MSX-2 in dental follicle cells during osteogenic differentiation in vitro. Morsczeck, C. Calcif. Tissue Int. (2006) [Pubmed]
  13. Reassessing the Dlx code: the genetic regulation of branchial arch skeletal pattern and development. Depew, M.J., Simpson, C.A., Morasso, M., Rubenstein, J.L. J. Anat. (2005) [Pubmed]
  14. Genes and related proteins involved in amelogenesis imperfecta. Stephanopoulos, G., Garefalaki, M.E., Lyroudia, K. J. Dent. Res. (2005) [Pubmed]
  15. Novel COL1A1 mutation (G559C) [correction of G599C] associated with mild osteogenesis imperfecta and dentinogenesis imperfecta. Pallos, D., Hart, P.S., Cortelli, J.R., Vian, S., Wright, J.T., Korkko, J., Brunoni, D., Hart, T.C. Arch. Oral Biol. (2001) [Pubmed]
  16. Tricho-dento-osseous syndrome and amelogenesis imperfecta with taurodontism are genetically distinct conditions. Price, J.A., Wright, J.T., Walker, S.J., Crawford, P.J., Aldred, M.J., Hart, T.C. Clin. Genet. (1999) [Pubmed]
 
WikiGenes - Universities