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Gene Review: 

dcr-1  -  Protein DCR-1

Caenorhabditis elegans

Synonyms: Endoribonuclease dcr-1, K12H4.8
 
 
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High impact information on dcr-1

  • Furthermore, a combination of phenotypic abnormalities and RNA analysis suggests a role for dcr-1 in a regulatory pathway comprised of small temporal RNA (let-7) and its target (e.g., lin-41) [1].
  • Consistent with these findings, genes required for the biogenesis and function of short interfering RNAs and microRNAs, dicer (dcr-1 in Caenorhabditis elegans) and argonaute homologs, are essential for development in diverse organisms, including C. elegans [2].

References

  1. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Ketting, R.F., Fischer, S.E., Bernstein, E., Sijen, T., Hannon, G.J., Plasterk, R.H. Genes Dev. (2001) [Pubmed]
  2. Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes. Grishok, A., Sharp, P.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
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