Gene Review:
tpst-1 - Protein TPST-1
Caenorhabditis elegans
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High impact information on Y111B2A.15
- We found that RNAi of TPST-A suppressed the roller phenotype caused by mutations in the rol-6 collagen gene, suggesting that sulfation of collagen proteins may be important for proper organization of the extracellular cuticle matrix [1].
- We found that TPST-A was mainly expressed in the hypodermis, especially in the seam cells [1].
- The TPST-A RNAi significantly decreased the dityrosine level in the worms, raising the possibility that the sulfation process may be a pre-requisite for the collagen tyrosine cross-linking [1].
References
- Requirement of tyrosylprotein sulfotransferase-A for proper cuticle formation in the nematode C. elegans. Kim, T.H., Hwang, S.B., Jeong, P.Y., Lee, J., Cho, J.W. FEBS Lett. (2005) [Pubmed]
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