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Gene Review: 

daf-18  -  abnormal DAuer Formation

Caenorhabditis elegans

 
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Disease relevance of daf-18

  • Given the conservation of the PI3'K signaling pathway between C. elegans and mammals, the analysis of daf-18 PTEN mutant nematodes should shed light on the role of human PTEN in the etiology of metabolic disease, aging, and cancer [1].
 

High impact information on daf-18

  • We provide evidence that daf-18 elicits some functions independent of the downstream gene daf-16 [2].
  • In one example, daf-18 appears to constitute a cell-autonomous germline signal that converges with a somatic gonad signal mediated by ceh-18 at a kinase inhibition [2].
  • We show that at least 27 genes collaborate with the worm PTEN homolog daf-18 for various functions previously concealed by genetic redundancy, including embryogenesis, cuticle turnover, egg laying, and oocyte maturation [2].
  • Others have shown that mutation of daf-18 suppresses the life extension and constitutive dauer formation associated with daf-2 or age-1 mutants [3].
  • Similarly, we show that inactivation of daf-18 by RNA-mediated interference mimics this suppression, and that a wild-type daf-18 transgene rescues the dauer defect [3].
 

Biological context of daf-18

 

Other interactions of daf-18

References

  1. Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene. Gil, E.B., Malone Link, E., Liu, L.X., Johnson, C.D., Lees, J.A. Proc. Natl. Acad. Sci. U.S.A. (1999)
  2. Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN during C. elegans development. Suzuki, Y., Han, M. Genes Dev. (2006)
  3. Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN. Rouault, J.P., Kuwabara, P.E., Sinilnikova, O.M., Duret, L., Thierry-Mieg, D., Billaud, M. Curr. Biol. (1999)
  4. Uncoupling of pathways that promote postmitotic life span and apoptosis from replicative immortality of Caenorhabditis elegans germ cells. Ahmed, S. Aging Cell (2006)
  5. Hormesis and aging in Caenorhabditis elegans. Cypser, J.R., Tedesco, P., Johnson, T.E. Exp. Gerontol. (2006)
  6. Hormesis in Caenorhabditis elegans dauer-defective mutants. Cypser, J.R., Johnson, T.E. Biogerontology. (2003)
 
 
 
 
 
 
 
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