Gene Review:
Mstn - myostatin
Mus musculus
Synonyms:
Cmpt, GDF-8, Gdf8, Growth/differentiation factor 8, Myostatin
- Functional improvement of dystrophic muscle by myostatin blockade. Bogdanovich, S., Krag, T.O., Barton, E.R., Morris, L.D., Whittemore, L.A., Ahima, R.S., Khurana, T.S. Nature (2002)
- Suppression of body fat accumulation in myostatin-deficient mice. McPherron, A.C., Lee, S.J. J. Clin. Invest. (2002)
- Myostatin inhibits myoblast differentiation by down-regulating MyoD expression. Langley, B., Thomas, M., Bishop, A., Sharma, M., Gilmour, S., Kambadur, R. J. Biol. Chem. (2002)
- Muscular atrophy of caveolin-3-deficient mice is rescued by myostatin inhibition. Ohsawa, Y., Hagiwara, H., Nakatani, M., Yasue, A., Moriyama, K., Murakami, T., Tsuchida, K., Noji, S., Sunada, Y. J. Clin. Invest. (2006)
- Antagonism of myostatin enhances muscle regeneration during sarcopenia. Siriett, V., Salerno, M.S., Berry, C., Nicholas, G., Bower, R., Kambadur, R., Sharma, M. Mol. Ther. (2007)
- A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep. Clop, A., Marcq, F., Takeda, H., Pirottin, D., Tordoir, X., Bibé, B., Bouix, J., Caiment, F., Elsen, J.M., Eychenne, F., Larzul, C., Laville, E., Meish, F., Milenkovic, D., Tobin, J., Charlier, C., Georges, M. Nat. Genet. (2006)
- Autoregulation of neurogenesis by GDF11. Wu, H.H., Ivkovic, S., Murray, R.C., Jaramillo, S., Lyons, K.M., Johnson, J.E., Calof, A.L. Neuron (2003)
- Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Rebbapragada, A., Benchabane, H., Wrana, J.L., Celeste, A.J., Attisano, L. Mol. Cell. Biol. (2003)
- Improved muscle healing through enhanced regeneration and reduced fibrosis in myostatin-null mice. McCroskery, S., Thomas, M., Platt, L., Hennebry, A., Nishimura, T., McLeay, L., Sharma, M., Kambadur, R. J. Cell. Sci. (2005)
- Muscle-bone interactions in dystrophin-deficient and myostatin-deficient mice. Montgomery, E., Pennington, C., Isales, C.M., Hamrick, M.W. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. (2005)
- Alterations of temporalis muscle contractile force and histological content from the myostatin and Mdx deficient mouse. Byron, C.D., Hamrick, M.W., Wingard, C.J. Arch. Oral Biol. (2006)
- Myostatin-deficient mice lose more skeletal muscle mass than wild-type controls during hindlimb suspension. McMahon, C.D., Popovic, L., Oldham, J.M., Jeanplong, F., Smith, H.K., Kambadur, R., Sharma, M., Maxwell, L., Bass, J.J. Am. J. Physiol. Endocrinol. Metab. (2003)
- Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin. Reisz-Porszasz, S., Bhasin, S., Artaza, J.N., Shen, R., Sinha-Hikim, I., Hogue, A., Fielder, T.J., Gonzalez-Cadavid, N.F. Am. J. Physiol. Endocrinol. Metab. (2003)
- The function of Myostatin and strategies of Myostatin blockade-new hope for therapies aimed at promoting growth of skeletal muscle. Patel, K., Amthor, H. Neuromuscul. Disord. (2005)
- Inhibition of preadipocyte differentiation by myostatin treatment in 3T3-L1 cultures. Kim, H.S., Liang, L., Dean, R.G., Hausman, D.B., Hartzell, D.L., Baile, C.A. Biochem. Biophys. Res. Commun. (2001)
- Endogenous expression and localization of myostatin and its relation to myosin heavy chain distribution in C2C12 skeletal muscle cells. Artaza, J.N., Bhasin, S., Mallidis, C., Taylor, W., Ma, K., Gonzalez-Cadavid, N.F. J. Cell. Physiol. (2002)
- Follistatin complexes Myostatin and antagonises Myostatin-mediated inhibition of myogenesis. Amthor, H., Nicholas, G., McKinnell, I., Kemp, C.F., Sharma, M., Kambadur, R., Patel, K. Dev. Biol. (2004)
- Myostatin propeptide-mediated amelioration of dystrophic pathophysiology. Bogdanovich, S., Perkins, K.J., Krag, T.O., Whittemore, L.A., Khurana, T.S. FASEB J. (2005)
- Improved success of myoblast transplantation in mdx mice by blocking the myostatin signal. Benabdallah, B.F., Bouchentouf, M., Tremblay, J.P. Transplantation (2005)
- Extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase pathway is involved in myostatin-regulated differentiation repression. Yang, W., Chen, Y., Zhang, Y., Wang, X., Yang, N., Zhu, D. Cancer Res. (2006)
- Myostatin negatively regulates satellite cell activation and self-renewal. McCroskery, S., Thomas, M., Maxwell, L., Sharma, M., Kambadur, R. J. Cell Biol. (2003)
- Relationships between transforming growth factor-beta1, myostatin, and decorin: implications for skeletal muscle fibrosis. Zhu, J., Li, Y., Shen, W., Qiao, C., Ambrosio, F., Lavasani, M., Nozaki, M., Branca, M.F., Huard, J. J. Biol. Chem. (2007)
- Expression of growth/differentiation factor 11, a new member of the BMP/TGFbeta superfamily during mouse embryogenesis. Nakashima, M., Toyono, T., Akamine, A., Joyner, A. Mech. Dev. (1999)
- P27 knockout mice: reduced myostatin in muscle and altered adipogenesis. Lin, J., Della-Fera, M.A., Li, C., Page, K., Choi, Y.H., Hartzell, D.L., Baile, C.A. Biochem. Biophys. Res. Commun. (2003)
- The myostatin gene is a downstream target gene of basic helix-loop-helix transcription factor MyoD. Spiller, M.P., Kambadur, R., Jeanplong, F., Thomas, M., Martyn, J.K., Bass, J.J., Sharma, M. Mol. Cell. Biol. (2002)
- Proteolytic processing of myostatin is auto-regulated during myogenesis. McFarlane, C., Langley, B., Thomas, M., Hennebry, A., Plummer, E., Nicholas, G., McMahon, C., Sharma, M., Kambadur, R. Dev. Biol. (2005)