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mt-Nd2  -  NADH dehydrogenase 2, mitochondrial

Mus musculus

Synonyms: AU018363, AU018541, AU018611, AU019859, AU020737, ...
 
 
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Disease relevance of mt-Nd2

 

High impact information on mt-Nd2

  • ND2 is a subunit of complex I in mitochondria, but we find that ND2 interacts with Src outside this organelle at excitatory synapses in the brain [5].
  • The latter contribution is most likely via a single nucleotide polymorphism in mt-Nd2 [2].
  • RESULTS: An ALR-specific sequence variation in the mt-Nd2 gene producing a leucine to methionine substitution at amino acid residue 276 in the NADH dehydrogenase 2 was discovered [2].
  • As in other D. yakuba mitochondrial polypeptide genes, AGA codons in the URF2 and COI genes do not correspond in position to arginine-specifying codons in the equivalent genes of mouse and yeast mtDNAs, but do most frequently correspond to serine-specifying codons [6].
  • The data further establish that the genes for tRNAile, tRNAgln, tRNAf-met and URF2 lie in the order given, on the opposite side of the A+T-rich region to the rRNA genes and, except for tRNAgln, are contained in the opposite strand to the rRNA, tRNAval and URF1 genes [7].
 

Biological context of mt-Nd2

  • This is in contrast to mammalian mtDNAs where all of these genes are located on the side of the replication origin which is replicated last, within the order tRNAphe, small (12S) rRNA, tRNAval, large (16S) rRNA, tRNAleu, URF1, tRNAile, tRNAgln, tRNAf-met and URF2, and, except tRNAgln, are all contained in the same (H) strand [7].
  • These findings indicated that cytotoxicity to Nd2-positive PC cells during MLTC is induced by ADCC [8].
 

Anatomical context of mt-Nd2

  • Cytotoxicity to pancreatic cancer (PC) cell lines, including Nd2 antigen-positive (SW1990, RWP-1, Capan-1) and Nd2 antigen-negative (Panc-1, MiaPaca-2, Capan-2) lines, was evaluated by mixed human leukocyte and tumor cell culture (MLTC) at an effector cell to target cell (E / T) ratio of 50 with or without Nd2 [8].
  • Granulocyte-colony stimulating factor enhances chimeric antibody Nd2 dependent cytotoxicity against pancreatic cancer mediated by polymorphonuclear neutrophils [3].
 

Associations of mt-Nd2 with chemical compounds

  • Neither Nd2 alone nor Adriamycin alone inhibited growth when administered at the same dose as the conjugate [9].
 

Analytical, diagnostic and therapeutic context of mt-Nd2

  • Thus (131)I-labeled Nd2 may have clinical application in the radioimmunotherapy of pancreatic cancer [4].
  • We investigated the biodistribution, radiolocalization, and radioimmunotherapeutic potential of (131)I-labeled Nd2 in athymic nude mice bearing human pancreatic carcinoma xenografts [4].
  • Antibody-dependent cytotoxicity mediated by chimeric monoclonal antibody Nd2 and experimental immunotherapy for pancreatic cancer [8].
  • These results indicate that Nd2 has high specificity and reactivity for pancreatic cancer and may have possible applicants in radioimmunodetection or targeting of therapeutic drugs in pancreatic cancer [10].
  • When these mice were scanned with a gamma camera, labeled Nd2 was shown to accumulate in the tumor rapidly on the 1st day after injection and by the 4th day tumor accumulation was more distinctly visualized than non-specific accumulation in liver [10].

References

  1. Nematospiroides dubius: passive transfer of protective immunity to mice with monoclonal antibodies. East, I.J., Washington, E.A., Brindley, P.J., Monroy, G.F., Scott-Young, N. Exp. Parasitol. (1988) [Pubmed]
  2. mt-Nd2 Allele of the ALR/Lt mouse confers resistance against both chemically induced and autoimmune diabetes. Mathews, C.E., Leiter, E.H., Spirina, O., Bykhovskaya, Y., Gusdon, A.M., Ringquist, S., Fischel-Ghodsian, N. Diabetologia (2005) [Pubmed]
  3. Granulocyte-colony stimulating factor enhances chimeric antibody Nd2 dependent cytotoxicity against pancreatic cancer mediated by polymorphonuclear neutrophils. Tamamori, Y., Sawada, T., Nishihara, T., Yamashita, Y., Ohira, M., Ho, J.J., Kim, Y.S., Hirakawa-Y S Chung, K. Int. J. Oncol. (2002) [Pubmed]
  4. Radioimmunotherapy for pancreatic carcinoma using (131)I-labeled monoclonal antibody Nd2 in xenografted nude mice. Inui, A., Chung, Y.S., Sawada, T., Kondo, Y., Ho, J.J., Kim, Y.S., Sowa, M. Jpn. J. Cancer Res. (1996) [Pubmed]
  5. Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2. Gingrich, J.R., Pelkey, K.A., Fam, S.R., Huang, Y., Petralia, R.S., Wenthold, R.J., Salter, M.W. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  6. Genes for cytochrome c oxidase subunit I, URF2, and three tRNAs in Drosophila mitochondrial DNA. Clary, D.O., Wolstenholme, D.R. Nucleic Acids Res. (1983) [Pubmed]
  7. Drosophila mitochondrial DNA: a novel gene order. Clary, D.O., Goddard, J.M., Martin, S.C., Fauron, C.M., Wolstenholme, D.R. Nucleic Acids Res. (1982) [Pubmed]
  8. Antibody-dependent cytotoxicity mediated by chimeric monoclonal antibody Nd2 and experimental immunotherapy for pancreatic cancer. Nishihara, T., Sawada, T., Yamamoto, A., Yamashita, Y., Ho, J.J., Kim, Y.S., Chung, K.H. Jpn. J. Cancer Res. (2000) [Pubmed]
  9. Intratumoral injection of an adriamycin immunoconjugate against human pancreatic cancer xenografts. Kondo, Y., Chung, Y.S., Sawada, T., Inui, A., Yamashita, Y., Hirayama, K., Nakata, B., Ho, J.J., Kim, Y.S., Sowa, M. Jpn. J. Cancer Res. (1995) [Pubmed]
  10. Tumor localization and biodistribution with radiolabeled monoclonal antibody against pancreatic cancer in tumor-bearing nude mice. Chung, Y.S., Sawada, T., Kondo, Y., Ho, J.J., Kim, Y.S., Sowa, M. Tohoku J. Exp. Med. (1992) [Pubmed]
 
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