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Gene Review

jnk-1  -  Protein JNK-1

Caenorhabditis elegans

 
 
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Disease relevance of jnk-1

  • In Caenorhabditis elegans a PMK-1 p38 MAPK pathway is required for resistance to bacterial infection, and a KGB-1 JNK-like MAPK pathway has recently been shown to mediate resistance to heavy metal stress [1].
 

High impact information on jnk-1

  • jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans [2].
  • The c-Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase (MAPK) family, was shown to be involved in the response to various stresses in cultured cells [3].
  • Both jnk-1 and jkk-1 are expressed in most neurons. jkk-1 null mutant animals exhibit defects in locomotion that can be rescued by the conditional expression of JKK-1 in mutant adults, suggesting that the defect is not due to a developmental error [4].
  • Thus, the C.elegans JNK pathway functions in type-D GABAergic motor neurons and thereby modulates coordinated locomotion [4].
 

Biological context of jnk-1

 

Other interactions of jnk-1

  • We identified the Caenorhabditis elegans mek-1 gene, which encodes a 347 amino acid protein highly homologous to mammalian MKK7, an activator of JNK [3].

References

  1. Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase. Kim, D.H., Liberati, N.T., Mizuno, T., Inoue, H., Hisamoto, N., Matsumoto, K., Ausubel, F.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans. Villanueva, A., Lozano, J., Morales, A., Lin, X., Deng, X., Hengartner, M.O., Kolesnick, R.N. EMBO J. (2001) [Pubmed]
  3. A Caenorhabditis elegans MAP kinase kinase, MEK-1, is involved in stress responses. Koga, M., Zwaal, R., Guan, K.L., Avery, L., Ohshima, Y. EMBO J. (2000) [Pubmed]
  4. A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons. Kawasaki, M., Hisamoto, N., Iino, Y., Yamamoto, M., Ninomiya-Tsuji, J., Matsumoto, K. EMBO J. (1999) [Pubmed]
 
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