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Gene Review: 

rho-1  -  Protein RHO-1

Caenorhabditis elegans

Synonyms: Ras-like GTP-binding protein rhoA, Y51H4A.3, rhoa
 
 
 
 
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High impact information on rho-1

  • Mutations in let-502 ROCK, a homologue of a RhoA effector in mammals, also cause defects in P cell migration, suggesting that it may be one of several effectors acting downstream of rho-1 during P cell migration [1].
  • We show that eliminating or reducing rho-1 gene function by using a dominant-negative transgene or dsRNA interference results in a severe defect in migration of hypodermal P cells to a ventral position [1].

References

  1. A RHO GTPase-mediated pathway is required during P cell migration in Caenorhabditis elegans. Spencer, A.G., Orita, S., Malone, C.J., Han, M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
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