Disease relevance of Myo1f

• In vivo, Myo1f-deficient mice showed increased susceptibility to infection by Listeria monocytogenes and an impaired neutrophil response [1].

High impact information on Myo1f

• Myo1c and Myo1f were mapped by in situ hybridization to the chromosomal regions 11D-11E and 17B-17C, respectively [2].
• The tail of Myo1f includes (1) a TH-1 region rich in basic residues, which may interact with anionic membrane phospholipids; (2) a TH-2 proline-rich region, expected to contain an ATP-insensitive actin-binding site; and (3) a SH-3 domain found in a variety of cytoskeletal and signaling proteins [2].
• Modulation of cell adhesion and motility in the immune system by Myo1f [1].
• Thus, Myo1f directs immune cell motility and innate host defense against infection [1].
• Cells from Myo1f-deficient mice exhibited abnormally increased adhesion and reduced motility, resulting from augmented exocytosis of beta2 integrin-containing granules [1].

Anatomical context of Myo1f

• We demonstrated that one of these proteins, Myo1f, is expressed predominantly in the mammalian immune system [1].

Analytical, diagnostic and therapeutic context of Myo1f

• Northern blot analysis indicated that the genes encoding Myo1c and Myo1f display a widespread tissue expression in the adult mouse [2].

References