Gene Review:
Ndn - necdin
Mus musculus
Synonyms:
AI528698, Necdin, Peg6
- Essential role for the Prader-Willi syndrome protein necdin in axonal outgrowth. Lee, S., Walker, C.L., Karten, B., Kuny, S.L., Tennese, A.A., O'Neill, M.A., Wevrick, R. Hum. Mol. Genet. (2005)
- Necdin interacts with the Msx2 homeodomain protein via MAGE-D1 to promote myogenic differentiation of C2C12 cells. Kuwajima, T., Taniura, H., Nishimura, I., Yoshikawa, K. J. Biol. Chem. (2004)
- Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1. Taniura, H., Taniguchi, N., Hara, M., Yoshikawa, K. J. Biol. Chem. (1998)
- Necdin is expressed in cachectic skeletal muscle to protect fibers from tumor-induced wasting. Sciorati, C., Touvier, T., Buono, R., Pessina, P., François, S., Perrotta, C., Meneveri, R., Clementi, E., Brunelli, S. J. Cell. Sci. (2009)
- A necdin/MAGE-like gene in the chromosome 15 autism susceptibility region: expression, imprinting, and mapping of the human and mouse orthologues. Chibuk, T.K., Bischof, J.M., Wevrick, R. BMC Genet. (2001)
- Disruption of the mouse necdin gene results in early post-natal lethality. Gérard, M., Hernandez, L., Wevrick, R., Stewart, C.L. Nat. Genet. (1999)
- Necdin-deficient mice do not show lethality or the obesity and infertility of Prader-Willi syndrome. Tsai, T.F., Armstrong, D., Beaudet, A.L. Nat. Genet. (1999)
- Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Tseng, Y.H., Butte, A.J., Kokkotou, E., Yechoor, V.K., Taniguchi, C.M., Kriauciunas, K.M., Cypess, A.M., Niinobe, M., Yoshikawa, K., Patti, M.E., Kahn, C.R. Nat. Cell Biol. (2005)
- Neuronally-expressed necdin gene: an imprinted candidate gene in Prader-Willi syndrome. Sutcliffe, J.S., Han, M., Christian, S.L., Ledbetter, D.H. Lancet (1997)
- NSCL-1 and NSCL-2 synergistically determine the fate of GnRH-1 neurons and control necdin gene expression. Krüger, M., Ruschke, K., Braun, T. EMBO J. (2004)
- Structure and expression of the mouse necdin gene. Identification of a postmitotic neuron-restrictive core promoter. Uetsuki, T., Takagi, K., Sugiura, H., Yoshikawa, K. J. Biol. Chem. (1996)
- The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse. MacDonald, H.R., Wevrick, R. Hum. Mol. Genet. (1997)
- Necdin downregulates CDC2 expression to attenuate neuronal apoptosis. Kurita, M., Kuwajima, T., Nishimura, I., Yoshikawa, K. J. Neurosci. (2006)
- Paternal deletion from Snrpn to Ube3a in the mouse causes hypotonia, growth retardation and partial lethality and provides evidence for a gene contributing to Prader-Willi syndrome. Tsai, T.F., Jiang, Y.H., Bressler, J., Armstrong, D., Beaudet, A.L. Hum. Mol. Genet. (1999)
- Cellular and subcellular localization of necdin in fetal and adult mouse brain. Niinobe, M., Koyama, K., Yoshikawa, K. Dev. Neurosci. (2000)
- Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death. Andrieu, D., Meziane, H., Marly, F., Angelats, C., Fernandez, P.A., Muscatelli, F. BMC Dev. Biol. (2006)
- Disruption of the mouse Necdin gene results in hypothalamic and behavioral alterations reminiscent of the human Prader-Willi syndrome. Muscatelli, F., Abrous, D.N., Massacrier, A., Boccaccio, I., Le Moal, M., Cau, P., Cremer, H. Hum. Mol. Genet. (2000)
- Biochemical characterization of mouse brain necdin. Maruyama, E. Biochem. J. (1996)
- Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survival. Kuwako, K., Hosokawa, A., Nishimura, I., Uetsuki, T., Yamada, M., Nada, S., Okada, M., Yoshikawa, K. J. Neurosci. (2005)
- Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor. Kuwako, K., Taniura, H., Yoshikawa, K. J. Biol. Chem. (2004)
- Expression of the Prader-Willi gene Necdin during mouse nervous system development correlates with neuronal differentiation and p75NTR expression. Andrieu, D., Watrin, F., Niinobe, M., Yoshikawa, K., Muscatelli, F., Fernandez, P.A. Gene Expr. Patterns (2003)
- Necdin is required for terminal differentiation and survival of primary dorsal root ganglion neurons. Takazaki, R., Nishimura, I., Yoshikawa, K. Exp. Cell Res. (2002)
- Necdin acts as a transcriptional repressor that interacts with multiple guanosine clusters. Matsumoto, K., Taniura, H., Uetsuki, T., Yoshikawa, K. Gene (2001)