The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Npas2  -  neuronal PAS domain protein 2

Mus musculus

Synonyms: MOP4, Neuronal PAS domain-containing protein 2, Neuronal PAS2, bHLHe9
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Npas2

  • MOP4 exhibits a robust rhythm in the vasculature, and retinoic acid can phase shift Per2 mRNA rhythmicity in vivo and in serum-induced smooth muscle cells in vitro, providing a molecular mechanism for hormonal control of clock gene expression [1].
  • Neuronal PAS domain protein 2 (NPAS2) is a transcription factor expressed primarily in the mammalian forebrain [2].
  • Neuronal PAS domain protein 2 (NPAS2) is a basic helix-loop-helix (bHLH) PAS domain transcription factor expressed in multiple regions of the vertebrate brain [3].
  • Transient transfection experiments demonstrated that the MOP3-MOP4 and MOP3-CLOCK complexes bound this element in COS-1 cells and drove transcription from a linked luciferase reporter gene [4].
  • Neuronal PAS domain protein 2 (NPAS2) is a circadian rhythm-associated transcription factor with two heme-binding sites on two PAS domains [5].
 

Biological context of Npas2

 

Anatomical context of Npas2

 

Associations of Npas2 with chemical compounds

 

Other interactions of Npas2

References

  1. Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. McNamara, P., Seo, S.P., Rudic, R.D., Sehgal, A., Chakravarti, D., FitzGerald, G.A. Cell (2001) [Pubmed]
  2. NPAS2: an analog of clock operative in the mammalian forebrain. Reick, M., Garcia, J.A., Dudley, C., McKnight, S.L. Science (2001) [Pubmed]
  3. Impaired cued and contextual memory in NPAS2-deficient mice. Garcia, J.A., Zhang, D., Estill, S.J., Michnoff, C., Rutter, J., Reick, M., Scott, K., Diaz-Arrastia, R., McKnight, S.L. Science (2000) [Pubmed]
  4. The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Hogenesch, J.B., Gu, Y.Z., Jain, S., Bradfield, C.A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  5. Spectroscopic and DNA-binding characterization of the isolated heme-bound basic helix-loop-helix-PAS-A domain of neuronal PAS protein 2 (NPAS2), a transcription activator protein associated with circadian rhythms. Mukaiyama, Y., Uchida, T., Sato, E., Sasaki, A., Sato, Y., Igarashi, J., Kurokawa, H., Sagami, I., Kitagawa, T., Shimizu, T. FEBS J. (2006) [Pubmed]
  6. Spectroscopic characterization of the isolated heme-bound PAS-B domain of neuronal PAS domain protein 2 associated with circadian rhythms. Koudo, R., Kurokawa, H., Sato, E., Igarashi, J., Uchida, T., Sagami, I., Kitagawa, T., Shimizu, T. FEBS J. (2005) [Pubmed]
  7. Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. Dudley, C.A., Erbel-Sieler, C., Estill, S.J., Reick, M., Franken, P., Pitts, S., McKnight, S.L. Science (2003) [Pubmed]
  8. Reciprocal regulation of haem biosynthesis and the circadian clock in mammals. Kaasik, K., Lee, C.C. Nature (2004) [Pubmed]
 
WikiGenes - Universities