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Gene Review

nex-4  -  Protein NEX-4

Caenorhabditis elegans

 
 
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Disease relevance of annexin

  • After verification of the protein as an annexin by peptide sequencing, an antiserum to the protein was prepared and used to isolate a corresponding cDNA from an expression library in phage lambda gt11 [1].
 

High impact information on annexin

  • The gene for this annexin (nex-1) was physically mapped to chromosome III in the vicinity of the dpy-17 genetic marker [1].
  • Two other annexin genes (nex-2 and nex-3) were also identified in chromosome III sequences reported by the nematode genomic sequencing project (Sulston, J., Z. Du, K. Thomas, R. Wilson, L. Hillier, R. Staden, N. Halloran, P. Green, J. Thierry-Mieg, L. Qiu, et al. 1992. Nature (Lond.). 356:37-41) [1].
  • The presence of the annexin in association with the membranes of the spermathecal valve suggests a novel function of the protein in the folding and unfolding of these membranes as eggs pass through the valve [1].
  • Possible phosphorylation sites in the NH2-terminal domain of the nematode annexin correspond to those of mammalian annexins [1].
  • The localizations also indicate roles for the annexin corresponding to those proposed in mammalian systems in membrane trafficking, collagen deposition, and extracellular matrix formation [1].
 

Biological context of annexin

 

Anatomical context of annexin

  • This low sensitivity to calcium suggests the annexin can only be activated in vivo near the plasma membrane or other sources of calcium [3].
  • Examination of transgenic offspring revealed specific nex-1 promoter activity in the pharynx, the hypodermal cells, the vulva, and the spermathecal valve, locations in which the annexin may function in collagen secretion/deposition and membrane-membrane interactions [3].
 

Analytical, diagnostic and therapeutic context of annexin

References

  1. Identification, localization, and functional implications of an abundant nematode annexin. Creutz, C.E., Snyder, S.L., Daigle, S.N., Redick, J. J. Cell Biol. (1996) [Pubmed]
  2. Annexin I is an endogenous ligand that mediates apoptotic cell engulfment. Arur, S., Uche, U.E., Rezaul, K., Fong, M., Scranton, V., Cowan, A.E., Mohler, W., Han, D.K. Dev. Cell (2003) [Pubmed]
  3. Transcription, biochemistry and localization of nematode annexins. Daigle, S.N., Creutz, C.E. J. Cell. Sci. (1999) [Pubmed]
 
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