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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

Olfr62  -  olfactory receptor 62

Mus musculus

Synonyms: GA_x6K02T2QD9B-18877756-18876809, H12, IH12, MOR258-5
 
 
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Disease relevance of Olfr62

  • None of the mice infected with the tolerant clones but all of the mice infected with H12 developed severe renal candidiasis after infection with 1.4 x 10(6) to 2.0 x 10(6) CFU/ml [1].
  • When dithiothreitol extracts of clone P and H12 were compared by immunoblot, both quantitative and qualitative differences in reactivities were observed with antibodies specific for the Candida C3d receptor and with antiserum from a patient with chronic mucocutaneous candidiasis [1].
  • The VE increase induced by hypoxia was greater at H12 (46 +/- 27%) because of T(TOT) response maturation [2].
 

High impact information on Olfr62

  • We have studied the state of TcR delta gene and the expression of T3 delta, T3 epsilon, T3 gamma and T11 (CD2) genes in the fetal thymocyte (FT) clones A2, G15, H5, E10, D5, H12, F1 and D11 obtained from a 14-day B10.BR mouse fetal thymus [3].
  • Four-color flow cytometry was used to identify the lineages present using the following antibodies: MAC1 (granulocytes and macrophages), F4/80 (macrophages), B54.2 (mast cells), and H12 (anti-Thy1.2 to identify myeloid precursors) [4].
  • Specific-locus mutations in the ad-3 region of heterokaryon H12 result from gene/point mutations at the closely linked ad-3A and ad-3B loci, multilocus deletion mutations and multiple-locus mutations [5].
  • A total of 208 ad-3 mutants recovered after exposure of growing cultures of H-12 to 1 mg of procarbazine/ml, and 2 ad-3 mutants of spontaneous origin, were characterized genetically [6].
  • KQAGD and AGDV, but not H12, fibrinogen peptides induce osteoclast 'rounding' on osteopontin suggesting there is an alternative anti-adhesive signal to 'RGD.' However, adhesion is not completely inhibited and is not specific for osteopontin as equivalent effects are seen with adhesion to serum [7].
 

Analytical, diagnostic and therapeutic context of Olfr62

  • These results demonstrate that vaccination with the H12 fragment stimulates long-lasting protective immunity [8].

References

  1. Isolation of avirulent clones of Candida albicans with reduced ability to recognize the CR2 ligand C3d. Franzke, S., Calderone, R.A., Schaller, K. Infect. Immun. (1993) [Pubmed]
  2. Maturation of baseline breathing and of hypercapnic and hypoxic ventilatory responses in newborn mice. Renolleau, S., Dauger, S., Autret, F., Vardon, G., Gaultier, C., Gallego, J. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2001) [Pubmed]
  3. Thymocyte clones from 14-day mouse embryos. II. Transcription of T3 gamma gene may precede rearrangement of TcR delta and expression of T3 delta, T3 epsilon and T11 genes. Pelkonen, J., Tunnacliffe, A., Palacios, R. Eur. J. Immunol. (1988) [Pubmed]
  4. 13-cis retinoic acid augments the production of macrophages in mouse bone marrow cultures stimulated with interleukin 3. Bender, J.G., Stewart, C.C., Van Epps, D.E., Walker, D.E. Exp. Hematol. (1990) [Pubmed]
  5. Ethylene oxide: induction of specific-locus mutations in the ad-3 region of heterokaryon 12 of Neurospora crassa and implications for genetic risk assessment of human exposure in the workplace. de Serres, F.J., Brockman, H.E. Mutat. Res. (1995) [Pubmed]
  6. Mutagenic potency and specificity of procarbazine in the ad-3 forward-mutation test in growing cultures of heterokaryon 12 of Neurospora crassa. Brockman, H.E., de Serres, F.J. Mutat. Res. (1991) [Pubmed]
  7. Interaction of osteopontin with osteoclast integrins. Horton, M.A., Nesbit, M.A., Helfrich, M.H. Ann. N. Y. Acad. Sci. (1995) [Pubmed]
  8. Stimulation of long-lasting protection against Streptococcus pyogenes after intranasal vaccination with non adjuvanted fibronectin-binding domain of the SfbI protein. Schulze, K., Medina, E., Chhatwal, G.S., Guzmán, C.A. Vaccine (2003) [Pubmed]
 
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