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Gene Review

DTNA  -  dystrobrevin, alpha

Homo sapiens

Synonyms: Alpha-dystrobrevin, D18S892E, DRP3, DTN, DTN-1, ...
 
 
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Disease relevance of DTNA

  • CONCLUSION: From these results, it is evident that DTN paste is not only an adjunct in the investigation, but can also be used as a temporary form of treatment of obstructive symptoms in Hirschsprung's disease patients [1].
 

High impact information on DTNA

  • Immunostaining studies indicate that DTN-B and DTN expression is absent in affected muscle fibers from DMD patients and carriers [2].
  • Strong CO labeling was present in the nucleus of the optic tract (NOT)-dorsal terminal nucleus (DTN) [3].
  • Clozapine inhibited rotation induced by SK & F 38393, apomorphine or N,N dipropyl A-5,6 DTN but failed to inhibit stereotypy [4].
  • 3 Contralateral rotation and stereotypy induced by apomorphine or N,N dipropyl A-5, 6 DTN were inhibited by haloperidol, pimozide and fluphenazine but these drugs failed to inhibit rotation induced by SK & F 38393 [4].
  • 2 Dopamine, apomorphine and 2-amino-5,6 and 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (A-5, 6 DTN, A-6, 7 DTN) and N,N dipropyl A-5, 6DTN induced both responses [4].
 

Biological context of DTNA

  • 1. The sulphydryl reagent 2-2'dithio bis-(5-nitropyridine) (DTNP) inhibited photophosphorylation when the chloroplasts were preincubated with the reagent in the light [5].
  • The stimulation of proton uptake and inhibition of electron transport by ATP was prevented by DTNP [5].
 

Anatomical context of DTNA

  • DTNA cleavage correlated with oxidation of NADH and reduction of protein disulfide bonds reported earlier in terms of location at the external plasma membrane surface, absolute specific activity, pH dependence and auxin specificity [6].
  • Furthermore, dendrites traverse large parts of the NOT/DTN forming a complex network that enables sampling and integration from a wide area [7].
  • The ultrastructural studies of the NOT/DTN complex have shown that GABAergic terminals with different morphological characteristics are present and that the GABA positive F and P terminals are widely distributed over somata and the adjacent neuropil [7].
  • Horseradish peroxidase injected into the inferior olivary nucleus retrogradely labelled neurons in the nucleus of the optic tract (NOT) and the dorsal terminal nucleus of the accessory optic tract (DTN) [8].
  • Positive stimulation sites lay in NOT, DTN, and in a fiber bundle in the pulvinar that is presumably a cortical input to NOT [9].
 

Associations of DTNA with chemical compounds

 

Analytical, diagnostic and therapeutic context of DTNA

  • We have determined the spin Hamiltonian of DTN using inelastic neutron diffraction measurements, and we have studied the high-field phase diagram by means of specific heat and magnetocaloric effect measurements [13].
  • This suggests that electrical stimulation of NOT and DTN had elicited the slow component of OKN, i.e., that component produced by the velocity storage mechanism in the vestibular system [9].
  • In all patients, ano-rectal manometry was performed before and after application of DTN paste (1 mg/kg/day in two separate doses) which was continued for a minimum period of 3 weeks [1].

References

  1. Anal achalasia after pull-through operations for Hirschsprung's disease -- preliminary experience with topical nitric oxide. Millar, A.J., Steinberg, R.M., Raad, J., Rode, H. European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie. (2002) [Pubmed]
  2. Identification and characterization of a novel member of the dystrobrevin gene family. Puca, A.A., Nigro, V., Piluso, G., Belsito, A., Sampaolo, S., Quaderi, N., Rossi, E., Di Iorio, G., Ballabio, A., Franco, B. FEBS Lett. (1998) [Pubmed]
  3. Cytochrome oxidase and NADPH-diaphorase on the afferent relay branch of the optokinetic reflex in the opossum. Vargas, C.D., Sousa, A.O., Bittencourt, F.L., Santos, C.M., Pereira Júnior, A., Bernardes, R.F., Rocha-Miranda, C.E., Volchan, E. J. Comp. Neurol. (1998) [Pubmed]
  4. Pharmacological evidence for the subclassification of central dopamine receptors in the rat. Gower, A.J., Marriott, A.S. Br. J. Pharmacol. (1982) [Pubmed]
  5. Sulphydryl groups in photosynthetic energy conservation. I. Light-dependent inhibition of photophosphorylation by the sulphydryl reagent 2-2'dithio bis-(5-nitropyridine). Andreo, C.S., Vallejos, R.H. Biochim. Biophys. Acta (1976) [Pubmed]
  6. Use of dipyridyl-dithio substrates to measure directly the protein disulfide-thiol interchange activity of the auxin stimulated NADH: protein disulfide reductase (NADH oxidase) of soybean plasma membranes. Morré, D.J., Gomez-Rey, M.L., Schramke, C., Em, O., Lawler, J., Hobeck, J., Morré, D.M. Mol. Cell. Biochem. (1999) [Pubmed]
  7. GABAergic neurons and circuits in the pretectal nuclei and the accessory optic system of mammals. van der Want, J.J., Nunes Cardozo, J.J., van der Togt, C. Prog. Brain Res. (1992) [Pubmed]
  8. Control of the optokinetic reflex by the nucleus of the optic tract in primates. Hoffmann, K.P. Prog. Brain Res. (1989) [Pubmed]
  9. Contribution of the nucleus of the optic tract to optokinetic nystagmus and optokinetic afternystagmus in the monkey: clinical implications. Cohen, B., Schiff, D., Buettner, J. Research publications - Association for Research in Nervous and Mental Disease. (1990) [Pubmed]
  10. Inhibitory effects of oxidants on n-type K+ channels in T lymphocytes and Xenopus oocytes. Szabó, I., Nilius, B., Zhang, X., Busch, A.E., Gulbins, E., Suessbrich, H., Lang, F. Pflugers Arch. (1997) [Pubmed]
  11. Comparative kinetic analysis of cholinesterase methods in rat and human erythrocytes and plasma. Dass, P.D., Offutt, D.M., Mejia, M.B., VanGoethem, D., Christenson, W.R., Landes, M.M., Stuart, B.P., Sangha, G.K., Thyssen, J.H. Veterinary and human toxicology. (1997) [Pubmed]
  12. Studies on deprotection of cysteine and selenocysteine side-chain protecting groups. Harris, K.M., Flemer, S., Hondal, R.J. J. Pept. Sci. (2007) [Pubmed]
  13. Bose-Einstein condensation of S = 1 nickel spin degrees of freedom in NiCl2-4SC(NH2)2. Zapf, V.S., Zocco, D., Hansen, B.R., Jaime, M., Harrison, N., Batista, C.D., Kenzelmann, M., Niedermayer, C., Lacerda, A., Paduan-Filho, A. Phys. Rev. Lett. (2006) [Pubmed]
 
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