Gene Review:
Pcsk5 - proprotein convertase subtilisin/kexin type 5
Mus musculus
Synonyms:
PC5, PC5/6A, PC5A, PC6, Proprotein convertase 5, ...
- Inhibiting uterine PC6 blocks embryo implantation: an obligatory role for a proprotein convertase in fertility. Nie, G., Li, Y., Wang, M., Liu, Y.X., Findlay, J.K., Salamonsen, L.A. Biol. Reprod. (2005)
- Biological heterogeneity, including systemic replication in mice, of H5N1 influenza A virus isolates from humans in Hong Kong. Gao, P., Watanabe, S., Ito, T., Goto, H., Wells, K., McGregor, M., Cooley, A.J., Kawaoka, Y. J. Virol. (1999)
- Response of a high-glucuronidase human tumour xenograft to aniline mustard. Warenius, H.M., Workman, P., Bleehen, N.M. Br. J. Cancer (1982)
- Activities of serine hydroxymethyltransferase in murine tissues and tumours. Tendler, S.J., Threadgill, M.D., Tisdale, M.J. Cancer Lett. (1987)
- SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis. Constam, D.B., Calfon, M., Robertson, E.J. J. Cell Biol. (1996)
- The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments. De Bie, I., Marcinkiewicz, M., Malide, D., Lazure, C., Nakayama, K., Bendayan, M., Seidah, N.G. J. Cell Biol. (1996)
- Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse. Essalmani, R., Hamelin, J., Marcinkiewicz, J., Chamberland, A., Mbikay, M., Chrétien, M., Seidah, N.G., Prat, A. Mol. Cell. Biol. (2006)
- Decidual differentiation of stromal cells promotes Proprotein Convertase 5/6 expression and lefty processing. Tang, M., Mikhailik, A., Pauli, I., Giudice, L.C., Fazelabas, A.T., Tulac, S., Carson, D.D., Kaufman, D.G., Barbier, C., Creemers, J.W., Tabibzadeh, S. Endocrinology (2005)
- Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4. Nakagawa, T., Hosaka, M., Torii, S., Watanabe, T., Murakami, K., Nakayama, K. J. Biochem. (1993)
- Specific and transient up-regulation of proprotein convertase 6 at the site of embryo implantation and identification of a unique transcript in mouse uterus during early pregnancy. Nie, G.Y., Li, Y., Minoura, H., Findlay, J.K., Salamonsen, L.A. Biol. Reprod. (2003)
- Subtilisin proprotein convertase-6 expression in the mouse uterus during implantation and artificially induced decidualization. Wong, B.S., Liu, S., Schultz, G.A., Rancourt, D.E. Mol. Reprod. Dev. (2002)
- The proprotein convertase PC5A and a metalloprotease are involved in the proteolytic processing of the neural adhesion molecule L1. Kalus, I., Schnegelsberg, B., Seidah, N.G., Kleene, R., Schachner, M. J. Biol. Chem. (2003)
- Murine subtilisin-like proteinase SPC6 is expressed during embryonic implantation, somitogenesis, and skeletal formation. Rancourt, S.L., Rancourt, D.E. Dev. Genet. (1997)
- The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases. Nour, N., Mayer, G., Mort, J.S., Salvas, A., Mbikay, M., Morrison, C.J., Overall, C.M., Seidah, N.G. Mol. Biol. Cell (2005)
- Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease. Nakagawa, T., Murakami, K., Nakayama, K. FEBS Lett. (1993)
- Phospholipid composition of small unilamellar liposomes containing melphalan influences drug action in mice bearing PC6 tumours. Large, P., Gregoriadis, G. Biochem. Pharmacol. (1983)
- The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates. Mayer, G., Hamelin, J., Asselin, M.C., Pasquato, A., Marcinkiewicz, E., Tang, M., Tabibzadeh, S., Seidah, N.G. J. Biol. Chem. (2008)
- Proteolytic processing of chromogranin B and secretogranin II by prohormone convertases. Laslop, A., Weiss, C., Savaria, D., Eiter, C., Tooze, S.A., Seidah, N.G., Winkler, H. J. Neurochem. (1998)