Gene Review:
Pdcd1 - programmed cell death 1
Mus musculus
Synonyms:
Ly101, PD-1, Pd1, Pdc1, Programmed cell death protein 1, ...
- The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice. Ansari, M.J., Salama, A.D., Chitnis, T., Smith, R.N., Yagita, H., Akiba, H., Yamazaki, T., Azuma, M., Iwai, H., Khoury, S.J., Auchincloss, H., Sayegh, M.H. J. Exp. Med. (2003)
- Differential role of programmed death-ligand 1 and programmed death-ligand 2 in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitis. Zhu, B., Guleria, I., Khosroshahi, A., Chitnis, T., Imitola, J., Azuma, M., Yagita, H., Sayegh, M.H., Khoury, S.J. J. Immunol. (2006)
- Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. Kanai, T., Totsuka, T., Uraushihara, K., Makita, S., Nakamura, T., Koganei, K., Fukushima, T., Akiba, H., Yagita, H., Okumura, K., Machida, U., Iwai, H., Azuma, M., Chen, L., Watanabe, M. J. Immunol. (2003)
- PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2. Carter, L., Fouser, L.A., Jussif, J., Fitz, L., Deng, B., Wood, C.R., Collins, M., Honjo, T., Freeman, G.J., Carreno, B.M. Eur. J. Immunol. (2002)
- Programmed cell death (apoptosis) in Alzheimer's disease and Creutzfeldt-Jakob disease. Jesionek-Kupnicka, D., Buczyński, J., Kordek, R., Sobów, T., Kłoszewska, I., Papierz, W., Liberski, P.P. Folia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences. (1997)
- Overexpression of wild-type presenilin 2 or its familial Alzheimer's disease-associated mutant does not induce or increase susceptibility to apoptosis in different cell lines. Gamliel, A., Teicher, C., Hartmann, T., Beyreuther, K., Stein, R. Neuroscience (2003)
- Programmed cell death in extraocular muscle tendon/sclera precursors. Sulik, K.K., Dehart, D.B., Johnson, C.S., Ellis, S.L., Chen, S.Y., Dunty, W.C., Zucker, R.M. Mol. Vis. (2001)
- Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice. Okazaki, T., Tanaka, Y., Nishio, R., Mitsuiye, T., Mizoguchi, A., Wang, J., Ishida, M., Hiai, H., Matsumori, A., Minato, N., Honjo, T. Nat. Med. (2003)
- Mitochondrial endonuclease G is important for apoptosis in C. elegans. Parrish, J., Li, L., Klotz, K., Ledwich, D., Wang, X., Xue, D. Nature (2001)
- Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Joza, N., Susin, S.A., Daugas, E., Stanford, W.L., Cho, S.K., Li, C.Y., Sasaki, T., Elia, A.J., Cheng, H.Y., Ravagnan, L., Ferri, K.F., Zamzami, N., Wakeham, A., Hakem, R., Yoshida, H., Kong, Y.Y., Mak, T.W., Zúñiga-Pflücker, J.C., Kroemer, G., Penninger, J.M. Nature (2001)
- Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Wang, C.Y., Cusack, J.C., Liu, R., Baldwin, A.S. Nat. Med. (1999)
- Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis. Lenardo, M.J. Nature (1991)
- Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice. Nishimura, H., Honjo, T., Minato, N. J. Exp. Med. (2000)
- Programmed cell death in the pathogenesis of murine IDDM: resistance to apoptosis induced in lymphocytes by cyclophosphamide. Colucci, F., Cilio, C.M., Lejon, K., Gonçalves, C.P., Bergman, M.L., Holmberg, D. J. Autoimmun. (1996)
- Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes. Wang, J., Yoshida, T., Nakaki, F., Hiai, H., Okazaki, T., Honjo, T. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Nishimura, H., Nose, M., Hiai, H., Minato, N., Honjo, T. Immunity (1999)
- Blocking programmed death-1 ligand-PD-1 interactions by local gene therapy results in enhancement of antitumor effect of secondary lymphoid tissue chemokine. He, Y.F., Zhang, G.M., Wang, X.H., Zhang, H., Yuan, Y., Li, D., Feng, Z.H. J. Immunol. (2004)
- The deficiency of immunoregulatory receptor PD-1 causes mild osteopetrosis. Nagahama, K., Aoki, K., Nonaka, K., Saito, H., Takahashi, M., Varghese, B.J., Shimokawa, H., Azuma, M., Ohya, K., Ohyama, K. Bone (2004)
- BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Watanabe, N., Gavrieli, M., Sedy, J.R., Yang, J., Fallarino, F., Loftin, S.K., Hurchla, M.A., Zimmerman, N., Sim, J., Zang, X., Murphy, T.L., Russell, J.H., Allison, J.P., Murphy, K.M. Nat. Immunol. (2003)
- Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. Freeman, G.J., Long, A.J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L.J., Malenkovich, N., Okazaki, T., Byrne, M.C., Horton, H.F., Fouser, L., Carter, L., Ling, V., Bowman, M.R., Carreno, B.M., Collins, M., Wood, C.R., Honjo, T. J. Exp. Med. (2000)
- Expression of programmed death 1 ligands by murine T cells and APC. Yamazaki, T., Akiba, H., Iwai, H., Matsuda, H., Aoki, M., Tanno, Y., Shin, T., Tsuchiya, H., Pardoll, D.M., Okumura, K., Azuma, M., Yagita, H. J. Immunol. (2002)
- Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. Wang, S., Bajorath, J., Flies, D.B., Dong, H., Honjo, T., Chen, L. J. Exp. Med. (2003)
- Blockade of B7-H1 with sPD-1 improves immunity against murine hepatocarcinoma. He, L., Zhang, G., He, Y., Zhu, H., Zhang, H., Feng, Z. Anticancer Res. (2005)
- Resolvin d series and protectin d1 mitigate acute kidney injury. Duffield, J.S., Hong, S., Vaidya, V.S., Lu, Y., Fredman, G., Serhan, C.N., Bonventre, J.V. J. Immunol. (2006)
- Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes. Serhan, C.N., Gotlinger, K., Hong, S., Lu, Y., Siegelman, J., Baer, T., Yang, R., Colgan, S.P., Petasis, N.A. J. Immunol. (2006)
- Programmed cell death is required for palate shelf fusion and is regulated by retinoic acid. Cuervo, R., Valencia, C., Chandraratna, R.A., Covarrubias, L. Dev. Biol. (2002)
- Interaction of B7RP-1 with ICOS negatively regulates antigen presentation by B cells. Wahl, P., Schoop, R., Horan, T.P., Yoshinaga, S.K., Wüthrich, R.P. Inflammation (2003)
- Programmed cell death of embryonic motoneurons triggered through the Fas death receptor. Raoul, C., Henderson, C.E., Pettmann, B. J. Cell Biol. (1999)
- Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. Blazar, B.R., Carreno, B.M., Panoskaltsis-Mortari, A., Carter, L., Iwai, Y., Yagita, H., Nishimura, H., Taylor, P.A. J. Immunol. (2003)
- Suppression of expression and function of negative immune regulator PD-1 by certain pattern recognition and cytokine receptor signals associated with immune system danger. Zhong, X., Bai, C., Gao, W., Strom, T.B., Rothstein, T.L. Int. Immunol. (2004)
- Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor. Shin, T., Kennedy, G., Gorski, K., Tsuchiya, H., Koseki, H., Azuma, M., Yagita, H., Chen, L., Powell, J., Pardoll, D., Housseau, F. J. Exp. Med. (2003)
- Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo. Sandner, S.E., Clarkson, M.R., Salama, A.D., Sanchez-Fueyo, A., Domenig, C., Habicht, A., Najafian, N., Yagita, H., Azuma, M., Turka, L.A., Sayegh, M.H. J. Immunol. (2005)
- B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism. Matsumoto, K., Inoue, H., Nakano, T., Tsuda, M., Yoshiura, Y., Fukuyama, S., Tsushima, F., Hoshino, T., Aizawa, H., Akiba, H., Pardoll, D., Hara, N., Yagita, H., Azuma, M., Nakanishi, Y. J. Immunol. (2004)
- Programmed death-1 targeting can promote allograft survival. Ozkaynak, E., Wang, L., Goodearl, A., McDonald, K., Qin, S., O'Keefe, T., Duong, T., Smith, T., Gutierrez-Ramos, J.C., Rottman, J.B., Coyle, A.J., Hancock, W.W. J. Immunol. (2002)
- Restoring function in exhausted CD8 T cells during chronic viral infection. Barber, D.L., Wherry, E.J., Masopust, D., Zhu, B., Allison, J.P., Sharpe, A.H., Freeman, G.J., Ahmed, R. Nature (2006)