Gene Review:
E2F1 - E2F transcription factor 1
Homo sapiens
Synonyms:
E2F-1, PBR3, RBAP-1, RBAP1, RBBP-3, ...
- Deregulated E2F transcriptional activity in autonomously growing melanoma cells. Halaban, R., Cheng, E., Smicun, Y., Germino, J. J. Exp. Med. (2000)
- Regulation of the cyclin E gene by transcription factor E2F1. Ohtani, K., DeGregori, J., Nevins, J.R. Proc. Natl. Acad. Sci. U.S.A. (1995)
- ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and antiestrogen resistance. Louie, M.C., Zou, J.X., Rabinovich, A., Chen, H.W. Mol. Cell. Biol. (2004)
- Elevated E2F1 inhibits transcription of the androgen receptor in metastatic hormone-resistant prostate cancer. Davis, J.N., Wojno, K.J., Daignault, S., Hofer, M.D., Kuefer, R., Rubin, M.A., Day, M.L. Cancer Res. (2006)
- Transdominant DeltaTAp73 isoforms are frequently up-regulated in ovarian cancer. Evidence for their role as epigenetic p53 inhibitors in vivo. Concin, N., Becker, K., Slade, N., Erster, S., Mueller-Holzner, E., Ulmer, H., Daxenbichler, G., Zeimet, A., Zeillinger, R., Marth, C., Moll, U.M. Cancer Res. (2004)
- Impact of E2F-1 expression on clinical outcome of gastric adenocarcinoma patients with adjuvant chemoradiation therapy. Lee, J., Park, C.K., Park, J.O., Lim, T., Park, Y.S., Lim, H.Y., Lee, I., Sohn, T.S., Noh, J.H., Heo, J.S., Kim, S., Lim, D.H., Kim, K.M., Kang, W.K. Clin. Cancer Res. (2008)
- Role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathology. Shimizu, S., Khan, M.Z., Hippensteel, R.L., Parkar, A., Raghupathi, R., Meucci, O. Neurobiol. Dis. (2007)
- Gene therapy approaches for the selective killing of cancer cells. Westphal, E.M., Melchner Hv, H. Curr. Pharm. Des. (2002)
- Up-regulation of E2F-1 in Down's syndrome brain exhibiting neuropathological features of Alzheimer-type dementia. Motonaga, K., Itoh, M., Hirayama, A., Hirano, S., Becker, L.E., Goto, Y., Takashima, S. Brain Res. (2001)
- Re-Evaluating Cell-Cycle Regulation by E2Fs. Rowland, B.D., Bernards, R. Cell (2006)
- Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Rubin, S.M., Gall, A.L., Zheng, N., Pavletich, N.P. Cell (2005)
- A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers. Tsuge, M., Hamamoto, R., Silva, F.P., Ohnishi, Y., Chayama, K., Kamatani, N., Furukawa, Y., Nakamura, Y. Nat. Genet. (2005)
- E2F1 expression in LNCaP prostate cancer cells deregulates androgen dependent growth, suppresses differentiation, and enhances apoptosis. Libertini, S.J., Tepper, C.G., Guadalupe, M., Lu, Y., Asmuth, D.M., Mudryj, M. Prostate (2006)
- All-trans retinoic acid converts E2F into a transcriptional suppressor and inhibits the growth of normal human bronchial epithelial cells through a retinoic acid receptor- dependent signaling pathway. Lee, H.Y., Dohi, D.F., Kim, Y.H., Walsh, G.L., Consoli, U., Andreeff, M., Dawson, M.I., Hong, W.K., Kurie, J.M. J. Clin. Invest. (1998)
- Tumor necrosis factor alpha inhibits cyclin A expression and retinoblastoma hyperphosphorylation triggered by insulin-like growth factor-I induction of new E2F-1 synthesis. Shen, W.H., Yin, Y., Broussard, S.R., McCusker, R.H., Freund, G.G., Dantzer, R., Kelley, K.W. J. Biol. Chem. (2004)
- Inhibition of retinoblastoma protein (Rb) phosphorylation at serine sites and an increase in Rb-E2F complex formation by silibinin in androgen-dependent human prostate carcinoma LNCaP cells: role in prostate cancer prevention. Tyagi, A., Agarwal, C., Agarwal, R. Mol. Cancer Ther. (2002)
- In human salivary gland cells, overexpression of E2F1 overcomes an interferon-gamma- and tumor necrosis factor-alpha-induced growth arrest but does not result in complete mitosis. Lillibridge, C.D., O'Connell, B.C. J. Cell. Physiol. (1997)
- Role of the p53-homologue p73 in E2F1-induced apoptosis. Stiewe, T., Pützer, B.M. Nat. Genet. (2000)
- Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Magnaghi-Jaulin, L., Groisman, R., Naguibneva, I., Robin, P., Lorain, S., Le Villain, J.P., Troalen, F., Trouche, D., Harel-Bellan, A. Nature (1998)
- Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Johnson, D.G., Ohtani, K., Nevins, J.R. Genes Dev. (1994)
- Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Lin, W.C., Lin, F.T., Nevins, J.R. Genes Dev. (2001)
- TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival. Liu, K., Luo, Y., Lin, F.T., Lin, W.C. Genes Dev. (2004)
- Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression. Schwarz, J.K., Bassing, C.H., Kovesdi, I., Datto, M.B., Blazing, M., George, S., Wang, X.F., Nevins, J.R. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Constitutive E2F1 overexpression delays endochondral bone formation by inhibiting chondrocyte differentiation. Scheijen, B., Bronk, M., van der Meer, T., Bernards, R. Mol. Cell. Biol. (2003)
- C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis. Gery, S., Gombart, A.F., Fung, Y.K., Koeffler, H.P. Blood (2004)
- Unbiased location analysis of E2F1-binding sites suggests a widespread role for E2F1 in the human genome. Bieda, M., Xu, X., Singer, M.A., Green, R., Farnham, P.J. Genome Res. (2006)
- A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53. Stanelle, J., Tu-Rapp, H., Pützer, B.M. Cell Death Differ. (2005)
- Regulation of E2F1 activity by acetylation. Martínez-Balbás, M.A., Bauer, U.M., Nielsen, S.J., Brehm, A., Kouzarides, T. EMBO J. (2000)
- Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. DeGregori, J., Kowalik, T., Nevins, J.R. Mol. Cell. Biol. (1995)
- Specific role for p300/CREB-binding protein-associated factor activity in E2F1 stabilization in response to DNA damage. Ianari, A., Gallo, R., Palma, M., Alesse, E., Gulino, A. J. Biol. Chem. (2004)
- Regulation of the cyclin D3 promoter by E2F1. Ma, Y., Yuan, J., Huang, M., Jove, R., Cress, W.D. J. Biol. Chem. (2003)
- Functional roles of E2F in cell cycle regulation. Fan, J., Bertino, J.R. Oncogene (1997)
- The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. McMahon, S.B., Van Buskirk, H.A., Dugan, K.A., Copeland, T.D., Cole, M.D. Cell (1998)
- Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage. Hsieh, J.K., Yap, D., O'Connor, D.J., Fogal, V., Fallis, L., Chan, F., Zhong, S., Lu, X. Mol. Cell. Biol. (2002)
- E2F-5, a new E2F family member that interacts with p130 in vivo. Hijmans, E.M., Voorhoeve, P.M., Beijersbergen, R.L., van 't Veer, L.J., Bernards, R. Mol. Cell. Biol. (1995)
- E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9. Oberley, M.J., Inman, D.R., Farnham, P.J. J. Biol. Chem. (2003)
- Transcriptional repression of the E2F-1 gene by interferon-alpha is mediated through induction of E2F-4/pRB and E2F-4/p130 complexes. Furukawa, Y., Iwase, S., Kikuchi, J., Nakamura, M., Yamada, H., Matsuda, M. Oncogene (1999)
- Genome-wide mapping of RELA(p65) binding identifies E2F1 as a transcriptional activator recruited by NF-kappaB upon TLR4 activation. Lim, C.A., Yao, F., Wong, J.J., George, J., Xu, H., Chiu, K.P., Sung, W.K., Lipovich, L., Vega, V.B., Chen, J., Shahab, A., Zhao, X.D., Hibberd, M., Wei, C.L., Lim, B., Ng, H.H., Ruan, Y., Chin, K.C. Mol. Cell (2007)
- Differential regulation of E2F transactivation by cyclin/cdk2 complexes. Dynlacht, B.D., Flores, O., Lees, J.A., Harlow, E. Genes Dev. (1994)
- Chk2 activates E2F-1 in response to DNA damage. Stevens, C., Smith, L., La Thangue, N.B. Nat. Cell Biol. (2003)
- Formation of the early-region-2 transcription-factor-1-retinoblastoma-protein (E2F-1-RB) transrepressor and release of the retinoblastoma protein from nuclear complexes containing cyclin A is induced by interferon alpha in U937V cells but not in interferon-alpha-resistant U937VR cells. Kirch, H.C., Putzer, B., Brockmann, D., Esche, H., Kloke, O. Eur. J. Biochem. (1997)
- Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. Hershko, T., Chaussepied, M., Oren, M., Ginsberg, D. Cell Death Differ. (2005)
- Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression. Wang, S., Fusaro, G., Padmanabhan, J., Chellappan, S.P. Oncogene (2002)
- A role for a p21-E2F interaction during senescence arrest of normal human fibroblasts. Afshari, C.A., Nichols, M.A., Xiong, Y., Mudryj, M. Cell Growth Differ. (1996)
- Modulation of Sp1-dependent transcription by a cis-acting E2F element in dhfr promoter. Park, K.K., Rue, S.W., Lee, I.S., Kim, H.C., Lee, I.K., Ahn, J.D., Kim, H.S., Yu, T.S., Kwak, J.Y., Heintz, N.H., Magae, J., Chang, Y.C. Biochem. Biophys. Res. Commun. (2003)
- PAC1 is a direct transcription target of E2F-1 in apoptotic signaling. Wu, J., Jin, Y.J., Calaf, G.M., Huang, W.L., Yin, Y. Oncogene (2007)
- Regulation of E2F1 function by the nuclear corepressor KAP1. Wang, C., Rauscher, F.J., Cress, W.D., Chen, J. J. Biol. Chem. (2007)
- The transcriptional coregulator RIP140 represses E2F1 activity and discriminates breast cancer subtypes. Docquier, A., Harmand, P.O., Fritsch, S., Chanrion, M., Darbon, J.M., Cavaillès, V. Clin. Cancer Res. (2010)
- A new component of the transcription factor DRTF1/E2F. Girling, R., Partridge, J.F., Bandara, L.R., Burden, N., Totty, N.F., Hsuan, J.J., La Thangue, N.B. Nature (1993)
- E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Müller, H., Bracken, A.P., Vernell, R., Moroni, M.C., Christians, F., Grassilli, E., Prosperini, E., Vigo, E., Oliner, J.D., Helin, K. Genes Dev. (2001)
- Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene. El Messaoudi, S., Fabbrizio, E., Rodriguez, C., Chuchana, P., Fauquier, L., Cheng, D., Theillet, C., Vandel, L., Bedford, M.T., Sardet, C. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Differential regulation of E2F1 apoptotic target genes in response to DNA damage. Pediconi, N., Ianari, A., Costanzo, A., Belloni, L., Gallo, R., Cimino, L., Porcellini, A., Screpanti, I., Balsano, C., Alesse, E., Gulino, A., Levrero, M. Nat. Cell Biol. (2003)
- Disruption of the pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha. Santoni-Rugiu, E., Jensen, M.R., Thorgeirsson, S.S. Cancer Res. (1998)
- Opposite functions for E2F1 and E2F4 in human epidermal keratinocyte differentiation. Paramio, J.M., Segrelles, C., Casanova, M.L., Jorcano, J.L. J. Biol. Chem. (2000)
- Modulation of E2F activity via signaling through surface IgM and CD40 receptors in WEHI-231 B lymphoma cells. Lam, E.W., Choi, M.S., van der Sman, J., Burbidge, S.A., Klaus, G.G. J. Biol. Chem. (1998)