Gene Review:
Pon1 - paraoxonase 1
Mus musculus
Synonyms:
A-esterase 1, Aromatic esterase 1, PON 1, Pon, Serum aryldialkylphosphatase 1, ...
- Human paraoxonase-1 overexpression inhibits atherosclerosis in a mouse model of metabolic syndrome. Mackness, B., Quarck, R., Verreth, W., Mackness, M., Holvoet, P. Arterioscler. Thromb. Vasc. Biol. (2006)
- The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism. Costa, L.G., Li, W.F., Richter, R.J., Shih, D.M., Lusis, A., Furlong, C.E. Chem. Biol. Interact. (1999)
- Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model. Shih, D.M., Gu, L., Hama, S., Xia, Y.R., Navab, M., Fogelman, A.M., Lusis, A.J. J. Clin. Invest. (1996)
- Expression of major HDL-associated antioxidant PON-1 is gender dependent and regulated during inflammation. bin Ali, A., Zhang, Q., Lim, Y.K., Fang, D., Retnam, L., Lim, S.K. Free Radic. Biol. Med. (2003)
- Mouse liver paraoxonase-1 gene expression is downregulated in hyperhomocysteinemia. Janel, N., Robert, K., Chabert, C., Ledru, A., Gouédard, C., Barouki, R., Delabar, J.M., Chassé, J.F. Thromb. Haemost. (2004)
- Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Shih, D.M., Gu, L., Xia, Y.R., Navab, M., Li, W.F., Hama, S., Castellani, L.W., Furlong, C.E., Costa, L.G., Fogelman, A.M., Lusis, A.J. Nature (1998)
- Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase. Aviram, M., Rosenblat, M., Bisgaier, C.L., Newton, R.S., Primo-Parmo, S.L., La Du, B.N. J. Clin. Invest. (1998)
- Paraoxonase protects against chlorpyrifos toxicity in mice. Li, W.F., Furlong, C.E., Costa, L.G. Toxicol. Lett. (1995)
- The effects of phenobarbital pretreatment on the metabolism and toxicity of paraoxon in the mouse. Vitarius, J.A., O'Shaughnessy, J.A., Sultatos, L.G. Pharmacol. Toxicol. (1995)
- The genetic mapping and gene structure of mouse paraoxonase/arylesterase. Sorenson, R.C., Primo-Parmo, S.L., Camper, S.A., La Du, B.N. Genomics (1995)
- A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids. Shih, D.M., Kast-Woelbern, H.R., Wong, J., Xia, Y.R., Edwards, P.A., Lusis, A.J. J. Lipid Res. (2006)
- Facilitated replacement of Kupffer cells expressing a paraoxonase-1 transgene is essential for ameliorating atherosclerosis in mice. Bradshaw, G., Gutierrez, A., Miyake, J.H., Davis, K.R., Li, A.C., Glass, C.K., Curtiss, L.K., Davis, R.A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Lysophosphatidylcholine (LPC) attenuates macrophage-mediated oxidation of LDL. Rosenblat, M., Oren, R., Aviram, M. Biochem. Biophys. Res. Commun. (2006)
- Reciprocal and coordinate regulation of serum amyloid A versus apolipoprotein A-I and paraoxonase-1 by inflammation in murine hepatocytes. Han, C.Y., Chiba, T., Campbell, J.S., Fausto, N., Chaisson, M., Orasanu, G., Plutzky, J., Chait, A. Arterioscler. Thromb. Vasc. Biol. (2006)
- Paraoxonase, a cardioprotective enzyme: continuing issues. Getz, G.S., Reardon, C.A. Curr. Opin. Lipidol. (2004)
- Paraoxonases 1, 2, and 3, oxidative stress, and macrophage foam cell formation during atherosclerosis development. Aviram, M., Rosenblat, M. Free Radic. Biol. Med. (2004)
- Bile acids decrease hepatic paraoxonase 1 expression and plasma high-density lipoprotein levels via FXR-mediated signaling of FGFR4. Gutierrez, A., Ratliff, E.P., Andres, A.M., Huang, X., McKeehan, W.L., Davis, R.A. Arterioscler. Thromb. Vasc. Biol. (2006)
- Folic acid supplementation delays atherosclerotic lesion development in apoE-deficient mice. Carnicer, R., A Navarro, M., Arbonés-Mainar, J.M., Acín, S., Guzmán, M.A., Surra, J.C., Arnal, C., de Las Heras, M., Blanco-Vaca, F., Osada, J. Life Sci. (2007)
- Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration. Forte, T.M., Oda, M.N., Knoff, L., Frei, B., Suh, J., Harmony, J.A., Stuart, W.D., Rubin, E.M., Ng, D.S. J. Lipid Res. (1999)
- Paraoxonase-2 Deficiency Aggravates Atherosclerosis in Mice Despite Lower Apolipoprotein-B-containing Lipoproteins: ANTI-ATHEROGENIC ROLE FOR PARAOXONASE-2. Ng, C.J., Bourquard, N., Grijalva, V., Hama, S., Shih, D.M., Navab, M., Fogelman, A.M., Lusis, A.J., Young, S., Reddy, S.T. J. Biol. Chem. (2006)
- Hydroxytyrosol administration enhances atherosclerotic lesion development in apo e deficient mice. Acín, S., Navarro, M.A., Arbonés-Mainar, J.M., Guillén, N., Sarría, A.J., Carnicer, R., Surra, J.C., Orman, I., Segovia, J.C., Torre, R.d.e. .L., Covas, M.I., Fernández-Bolaños, J., Ruiz-Gutiérrez, V., Osada, J. J. Biochem. (2006)
- Eucommia ulmoides Oliver Leaf Extract Increases Endogenous Antioxidant Activity in Type 2 Diabetic Mice. Park, S.A., Choi, M.S., Jung, U.J., Kim, M.J., Kim, D.J., Park, H.M., Park, Y.B., Lee, M.K. Journal of medicinal food (2006)
- Oxidative stress is markedly elevated in lecithin:cholesterol acyltransferase-deficient mice and is paradoxically reversed in the apolipoprotein E knockout background in association with a reduction in atherosclerosis. Ng, D.S., Maguire, G.F., Wylie, J., Ravandi, A., Xuan, W., Ahmed, Z., Eskandarian, M., Kuksis, A., Connelly, P.W. J. Biol. Chem. (2002)