Gene Review:
Pou2af1 - POU domain, class 2, associating factor 1
Mus musculus
Synonyms:
B-cell-specific coactivator OBF-1, BOB-1, BOB.1, BOB1, Bob-1, ...
- Up-regulation of BOB.1/OBF.1 expression in normal germinal center B cells and germinal center-derived lymphomas. Greiner, A., Müller, K.B., Hess, J., Pfeffer, K., Müller-Hermelink, H.K., Wirth, T. Am. J. Pathol. (2000)
- Cutting edge: lack of peripheral B cells and severe agammaglobulinemia in mice simultaneously lacking Bruton's tyrosine kinase and the B cell-specific transcriptional coactivator OBF-1. Schubart, D.B., Rolink, A., Schubart, K., Matthias, P. J. Immunol. (2000)
- Oct-2 and Bob-1 deficiency in Hodgkin and Reed Sternberg cells. Re, D., Müschen, M., Ahmadi, T., Wickenhauser, C., Staratschek-Jox, A., Holtick, U., Diehl, V., Wolf, J. Cancer Res. (2001)
- Nontranscriptional regulation of SYK by the coactivator OCA-B is required at multiple stages of B cell development. Siegel, R., Kim, U., Patke, A., Yu, X., Ren, X., Tarakhovsky, A., Roeder, R.G. Cell (2006)
- OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes. Casellas, R., Jankovic, M., Meyer, G., Gazumyan, A., Luo, Y., Roeder, R., Nussenzweig, M. Cell (2002)
- B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation. Schubart, D.B., Rolink, A., Kosco-Vilbois, M.H., Botteri, F., Matthias, P. Nature (1996)
- Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells. Zwilling, S., Dieckmann, A., Pfisterer, P., Angel, P., Wirth, T. Science (1997)
- Myosin light chain 1 atrial isoform (MLC1A) is expressed in pre-B cells under control of the BOB.1/OBF.1 coactivator. Laumen, H., Brunner, C., Greiner, A., Wirth, T. Nucleic Acids Res. (2004)
- The B lymphocyte-specific coactivator BOB.1/OBF.1 is required at multiple stages of B-cell development. Hess, J., Nielsen, P.J., Fischer, K.D., Bujard, H., Wirth, T. Mol. Cell. Biol. (2001)
- B lymphocytes are impaired in mice lacking the transcriptional co-activator Bob1/OCA-B/OBF1. Nielsen, P.J., Georgiev, O., Lorenz, B., Schaffner, W. Eur. J. Immunol. (1996)
- Functional characterization of the murine homolog of the B cell-specific coactivator BOB.1/OBF.1. Pfisterer, P., Zwilling, S., Hess, J., Wirth, T. J. Biol. Chem. (1995)
- B cell-specific transgenic expression of Bcl2 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient mice. Brunner, C., Marinkovic, D., Klein, J., Samardzic, T., Nitschke, L., Wirth, T. J. Exp. Med. (2003)
- The BOB.1 / OBF.1 co-activator is essential for octamer-dependent transcription in B cells. Laumen, H., Nielsen, P.J., Wirth, T. Eur. J. Immunol. (2000)
- Btk expression is controlled by Oct and BOB.1/OBF.1. Brunner, C., Wirth, T. Nucleic Acids Res. (2006)
- CD22 regulates early B cell development in BOB.1/OBF.1-deficient mice. Samardzic, T., Gerlach, J., Muller, K., Marinkovic, D., Hess, J., Nitschke, L., Wirth, T. Eur. J. Immunol. (2002)
- Knockout B lymphoma cell lines as biochemical tools to explore multiple signalling pathways. Veale, M.F., Dietrich, W.M., Corcoran, L.M. Immunol. Cell Biol. (2003)
- Transcriptional regulation of the murine 3' IgH enhancer by OCT-2. Tang, H., Sharp, P.A. Immunity (1999)
- Oct-2 regulates CD36 gene expression via a consensus octamer, which excludes the co-activator OBF-1. Shore, P., Dietrich, W., Corcoran, L.M. Nucleic Acids Res. (2002)
- Differential requirement for OBF-1 during antibody-secreting cell differentiation. Corcoran, L.M., Hasbold, J., Dietrich, W., Hawkins, E., Kallies, A., Nutt, S.L., Tarlinton, D.M., Matthias, P., Hodgkin, P.D. J. Exp. Med. (2005)
- Genetic analyses of NFKB1 and OCA-B function: defects in B cells, serum IgM level, and antibody responses in Nfkb1-/-Oca-b-/- mice. Kim, U., Gunther, C.S., Roeder, R.G. J. Immunol. (2000)
- Expression of the aldehyde dehydrogenase 2-like gene is controlled by BOB.1/OBF.1 in B lymphocytes. Brunner, C., Laumen, H., Nielsen, P.J., Kraut, N., Wirth, T. J. Biol. Chem. (2003)
- The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes. Kim, U., Qin, X.F., Gong, S., Stevens, S., Luo, Y., Nussenzweig, M., Roeder, R.G. Nature (1996)
- Identification of transcription coactivator OCA-B-dependent genes involved in antigen-dependent B cell differentiation by cDNA array analyses. Kim, U., Siegel, R., Ren, X., Gunther, C.S., Gaasterland, T., Roeder, R.G. Proc. Natl. Acad. Sci. U.S.A. (2003)
- The Ets factor Spi-B is a direct critical target of the coactivator OBF-1. Bartholdy, B., Du Roure, C., Bordon, A., Emslie, D., Corcoran, L.M., Matthias, P. Proc. Natl. Acad. Sci. U.S.A. (2006)