Gene Review:
Rapsn - receptor-associated protein of the synapse
Mus musculus
Synonyms:
43 kDa postsynaptic protein, 43 kDa receptor-associated protein of the synapse, 43kDa, 43kDa acetylcholine receptor-associated protein, Acetylcholine receptor-associated 43 kDa protein, ...
- Chick ciliary ganglion neurons contain transcripts coding for acetylcholine receptor-associated protein at synapses (rapsyn). Burns, A.L., Benson, D., Howard, M.J., Margiotta, J.F. J. Neurosci. (1997)
- Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse. Lin, W., Burgess, R.W., Dominguez, B., Pfaff, S.L., Sanes, J.R., Lee, K.F. Nature (2001)
- Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice. Gautam, M., Noakes, P.G., Mudd, J., Nichol, M., Chu, G.C., Sanes, J.R., Merlie, J.P. Nature (1995)
- Rapsyn is required for MuSK signaling and recruits synaptic components to a MuSK-containing scaffold. Apel, E.D., Glass, D.J., Moscoso, L.M., Yancopoulos, G.D., Sanes, J.R. Neuron (1997)
- Expression of RAPsyn (43K protein) and nicotinic acetylcholine receptor genes is not coordinately regulated in mouse muscle. Frail, D.E., Musil, L.S., Buonanno, A., Merlie, J.P. Neuron (1989)
- Characterization and mapping of the Rapsn gene encoding the 43-kDa acetylcholine receptor-associated protein. Gautam, M., Mudd, J., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Merlie, J.P. Genomics (1994)
- Distinct phenotypes of mutant mice lacking agrin, MuSK, or rapsyn. Gautam, M., DeChiara, T.M., Glass, D.J., Yancopoulos, G.D., Sanes, J.R. Brain Res. Dev. Brain Res. (1999)
- Identification of the mouse muscle 43,000-dalton acetylcholine receptor-associated protein (RAPsyn) by cDNA cloning. Frail, D.E., McLaughlin, L.L., Mudd, J., Merlie, J.P. J. Biol. Chem. (1988)
- Increased ratio of rapsyn to ACh receptor stabilizes postsynaptic receptors at the mouse neuromuscular synapse. Gervásio, O.L., Phillips, W.D. J. Physiol. (Lond.) (2005)
- Promotion of motoneuron survival and branching in rapsyn-deficient mice. Banks, G.B., Chau, T.N., Bartlett, S.E., Noakes, P.G. J. Comp. Neurol. (2001)
- Regulation of the rapsyn promoter by kaiso and delta-catenin. Rodova, M., Kelly, K.F., VanSaun, M., Daniel, J.M., Werle, M.J. Mol. Cell. Biol. (2004)
- Regulation of acetylcholine receptor clustering by the tumor suppressor APC. Wang, J., Jing, Z., Zhang, L., Zhou, G., Braun, J., Yao, Y., Wang, Z.Z. Nat. Neurosci. (2003)
- The mammalian 43-kD acetylcholine receptor-associated protein (RAPsyn) is expressed in some nonmuscle cells. Musil, L.S., Frail, D.E., Merlie, J.P. J. Cell Biol. (1989)
- Nitric oxide synthase (NOS-1) coclustered with agrin-induced AChR-specializations on cultured skeletal myotubes. Lück, G., Hoch, W., Hopf, C., Blottner, D. Mol. Cell. Neurosci. (2000)
- Overexpression of rapsyn inhibits agrin-induced acetylcholine receptor clustering in muscle cells. Han, H., Noakes, P.G., Phillips, W.D. J. Neurocytol. (1999)
- Interactions of the rapsyn RING-H2 domain with dystroglycan. Bartoli, M., Ramarao, M.K., Cohen, J.B. J. Biol. Chem. (2001)
- Rapsyn interaction with calpain stabilizes AChR clusters at the neuromuscular junction. Chen, F., Qian, L., Yang, Z.H., Huang, Y., Ngo, S.T., Ruan, N.J., Wang, J., Schneider, C., Noakes, P.G., Ding, Y.Q., Mei, L., Luo, Z.G. Neuron (2007)
- The synapse-associated protein rapsyn regulates tyrosine phosphorylation of proteins colocalized at nicotinic acetylcholine receptor clusters. Qu, Z., Apel, E.D., Doherty, C.A., Hoffman, P.W., Merlie, J.P., Huganir, R.L. Mol. Cell. Neurosci. (1996)
- Agrin-induced activation of acetylcholine receptor-bound Src family kinases requires Rapsyn and correlates with acetylcholine receptor clustering. Mittaud, P., Marangi, P.A., Erb-Vögtli, S., Fuhrer, C. J. Biol. Chem. (2001)
- Rapsyn escorts the nicotinic acetylcholine receptor along the exocytic pathway via association with lipid rafts. Marchand, S., Devillers-Thiéry, A., Pons, S., Changeux, J.P., Cartaud, J. J. Neurosci. (2002)