The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

MUC20  -  mucin 20, cell surface associated

Homo sapiens

Synonyms: FLJ14408, KIAA1359, MUC-20, Mucin-20, UNQ2782/PRO7170
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of MUC20

 

High impact information on MUC20

 

Biological context of MUC20

  • In renal tissues of IgAN, up-regulation of MUC20 expression in proximal tubules, as well as in distal tubules, was observed [2].
  • Up-regulation in the kidney and its genetic polymorphism of MUC20, a regulator of Met signaling cascade, in patients with IgA nephropathy [2].
  • The present study revealed that there is no association between the VNTR polymorphism of the MUC20 gene and the clinical manifestations in IgAN patients at the time of renal biopsy [4].
  • The frequencies of the alleles and genotypes of MUC20 VNTR polymorphisms did not differ between patients with IgAN and healthy controls [4].
 

Anatomical context of MUC20

  • Except for MUC20 in epididymis, mRNA for MUC1 and MUC20, both membrane-associated mucins, was detected in all tissues analysed [5].
  • Interestingly, in human MUC20, the repeat numbers of the extracellular tandem domain, which may have an influence on the oligomerization, showed a divergence, with two to six repeat types in several human cell lines [2].
  • Functional analyses of MUC20 have demonstrated its role as a negative regulator of hepatocyte growth factor (HGF)-induced Grb2-Ras pathway [2].
 

Other interactions of MUC20

  • MUC20 VNTR polymorphism was genotyped by polymerase chain reaction amplification and confirmed by sequencing [4].
 

Analytical, diagnostic and therapeutic context of MUC20

  • Northern blot and reverse transcription-PCR analyses revealed that human MUC20 mRNA was expressed most highly in kidney and moderately in placenta, colon, lung, prostate, and liver [1].
  • Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney [1].

References

  1. Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney. Higuchi, T., Orita, T., Nakanishi, S., Katsuya, K., Watanabe, H., Yamasaki, Y., Waga, I., Nanayama, T., Yamamoto, Y., Munger, W., Sun, H.W., Falk, R.J., Jennette, J.C., Alcorta, D.A., Li, H., Yamamoto, T., Saito, Y., Nakamura, M. J. Biol. Chem. (2004) [Pubmed]
  2. Up-regulation in the kidney and its genetic polymorphism of MUC20, a regulator of Met signaling cascade, in patients with IgA nephropathy. Narita, I., Alchi, B., Sato, F., Saga, D., Ogawa, A., Tsubata, Y., Kondo, D., Sakatsume, M., Yamamoto, T., Gejyo, F. Kidney Int. (2005) [Pubmed]
  3. MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met. Higuchi, T., Orita, T., Katsuya, K., Yamasaki, Y., Akiyama, K., Li, H., Yamamoto, T., Saito, Y., Nakamura, M. Mol. Cell. Biol. (2004) [Pubmed]
  4. Tandem repeats polymorphism of MUC20 is an independent factor for the progression of immunoglobulin A nephropathy. Li, G., Zhang, H., Lv, J., Hou, P., Wang, H. American journal of nephrology. (2006) [Pubmed]
  5. Mucin gene expression in human male urogenital tract epithelia. Russo, C.L., Spurr-Michaud, S., Tisdale, A., Pudney, J., Anderson, D., Gipson, I.K. Hum. Reprod. (2006) [Pubmed]
 
WikiGenes - Universities