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Gene Review

Srsf3  -  serine/arginine-rich splicing factor 3

Mus musculus

Synonyms: AL024116, Pre-mRNA-splicing factor SRP20, Protein X16, Serine/arginine-rich splicing factor 3, Sfrs3, ...
 
 
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Disease relevance of Sfrs3

 

High impact information on Sfrs3

  • The mouse gene encoding SRp20, termed Srp20, consists of one alternative exon and six constitutive exons and was mapped to a 2-centimorgan interval on chromosome 17 [2].
  • Regulated expression and RNA processing of transcripts from the Srp20 splicing factor gene during the cell cycle [2].
  • Death occurred at 10 days p.c. Since the combination of XO and trisomy 16 does not severely affect early mouse development, it is likely that regulatory mechanisms essential for early embryogenesis do not function correctly in XnX16 embryos due to activity of the extra X chromosome segment of X16 [3].
  • Matings between female mice carrying Searle's translocation, T(X;16)16H, and normal males give rise to chromosomally unbalanced zygotes with two complete sets of autosomes, one normal X chromosome and one X16 translocation chromosome (XnX16 embryos) [3].
  • The conserved protein motifs and expression pattern suggest that X16 could be involved in RNA processing correlating with cellular proliferation [4].
 

Biological context of Sfrs3

  • It is highly likely therefore that the ultimate inactivation pattern in T16H heterozygotes has been accomplished by (1) the inability of the X16 to become inactive; (2) inactivation in favor of the Xn; and (3) rapid elimination of 16x-inactive cells [5].
  • However, the frequency and distribution of beta-galactosidase-positive cells in X16/X(n)lacZ;16X/16 embryos at 6.5 and 7.5 dpc, together with earlier cytogenetic data, raised an intriguing possibility that the majority of 16X chromosomes were prevented from completing the inactivation process, when they had been chosen to be silenced [6].
 

Anatomical context of Sfrs3

References

 
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