Gene Review:
Sim1 - single-minded homolog 1 (Drosophila)
Mus musculus
Synonyms:
Single-minded homolog 1, bHLHe14, mSIM1
- Regulatory interaction between arylhydrocarbon receptor and SIM1, two basic helix-loop-helix PAS proteins involved in the control of food intake. Yang, C., Boucher, F., Tremblay, A., Michaud, J.L. J. Biol. Chem. (2004)
- Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus. Michaud, J.L., Boucher, F., Melnyk, A., Gauthier, F., Goshu, E., Lévy, E., Mitchell, G.A., Himms-Hagen, J., Fan, C.M. Hum. Mol. Genet. (2001)
- Adenoviral-mediated modulation of Sim1 expression in the paraventricular nucleus affects food intake. Yang, C., Gagnon, D., Vachon, P., Tremblay, A., Levy, E., Massie, B., Michaud, J.L. J. Neurosci. (2006)
- Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice. Holder, J.L., Zhang, L., Kublaoui, B.M., DiLeone, R.J., Oz, O.K., Bair, C.H., Lee, Y.H., Zinn, A.R. Am. J. Physiol. Endocrinol. Metab. (2004)
- Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1. Michaud, J.L., Rosenquist, T., May, N.R., Fan, C.M. Genes Dev. (1998)
- Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants. Goshu, E., Jin, H., Fasnacht, R., Sepenski, M., Michaud, J.L., Fan, C.M. Mol. Cell. Biol. (2002)
- Sim1 and Sim2 are required for the correct targeting of mammillary body axons. Marion, J.F., Yang, C., Caqueret, A., Boucher, F., Michaud, J.L. Development (2005)
- Identification of the downstream targets of SIM1 and ARNT2, a pair of transcription factors essential for neuroendocrine cell differentiation. Liu, C., Goshu, E., Wells, A., Fan, C.M. J. Biol. Chem. (2003)
- Defective development of secretory neurones in the hypothalamus of Arnt2-knockout mice. Hosoya, T., Oda, Y., Takahashi, S., Morita, M., Kawauchi, S., Ema, M., Yamamoto, M., Fujii-Kuriyama, Y. Genes Cells (2001)
- Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube. Sun, T., Echelard, Y., Lu, R., Yuk, D.I., Kaing, S., Stiles, C.D., Rowitch, D.H. Curr. Biol. (2001)
- Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome. Fan, C.M., Kuwana, E., Bulfone, A., Fletcher, C.F., Copeland, N.G., Jenkins, N.A., Crews, S., Martinez, S., Puelles, L., Rubenstein, J.L., Tessier-Lavigne, M. Mol. Cell. Neurosci. (1996)
- Sim2 contributes to neuroendocrine hormone gene expression in the anterior hypothalamus. Goshu, E., Jin, H., Lovejoy, J., Marion, J.F., Michaud, J.L., Fan, C.M. Mol. Endocrinol. (2004)
- ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus. Michaud, J.L., DeRossi, C., May, N.R., Holdener, B.C., Fan, C.M. Mech. Dev. (2000)