Gene Review:
EPHB2 - EPH receptor B2
Homo sapiens
Synonyms:
CAPB, DRT, Developmentally-regulated Eph-related tyrosine kinase, EK5, ELK-related tyrosine kinase, ...
- Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer. Huusko, P., Ponciano-Jackson, D., Wolf, M., Kiefer, J.A., Azorsa, D.O., Tuzmen, S., Weaver, D., Robbins, C., Moses, T., Allinen, M., Hautaniemi, S., Chen, Y., Elkahloun, A., Basik, M., Bova, G.S., Bubendorf, L., Lugli, A., Sauter, G., Schleutker, J., Ozcelik, H., Elowe, S., Pawson, T., Trent, J.M., Carpten, J.D., Kallioniemi, O.P., Mousses, S. Nat. Genet. (2004)
- A variant transcript encoding an isoform of the human protein tyrosine kinase EPHB2 is generated by alternative splicing and alternative use of polyadenylation signals. Tang, X.X., Pleasure, D.E., Brodeur, G.M., Ikegaki, N. Oncogene (1998)
- Expression profile of EFNB1, EFNB2, two ligands of EPHB2 in human gastric cancer. Kataoka, H., Tanaka, M., Kanamori, M., Yoshii, S., Ihara, M., Wang, Y.J., Song, J.P., Li, Z.Y., Arai, H., Otsuki, Y., Kobayashi, T., Konno, H., Hanai, H., Sugimura, H. J. Cancer Res. Clin. Oncol. (2002)
- Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease. Mei, M., Su, B., Harrison, K., Chao, M., Siedlak, S.L., Previll, L.A., Jackson, L., Cai, D.X., Zhu, X. J. Neurochem. (2006)
- ERK2: a logical AND gate critical for drug-induced plasticity? Girault, J.A., Valjent, E., Caboche, J., Hervé, D. Current opinion in pharmacology (2007)
- Reaction and movement time as a function of age and physical activity level. Spirduso, W.W. Journal of gerontology. (1975)
- Age differences and changes in reaction time: the Baltimore Longitudinal Study of Aging. Fozard, J.L., Vercryssen, M., Reynolds, S.L., Hancock, P.A., Quilter, R.E. Journal of gerontology. (1994)
- Regulation of Cdc25C by ERK-MAP Kinases during the G(2)/M Transition. Wang, R., He, G., Nelman-Gonzalez, M., Ashorn, C.L., Gallick, G.E., Stukenberg, P.T., Kirschner, M.W., Kuang, J. Cell (2007)
- Transactivation joins multiple tracks to the ERK/MAPK cascade. Wetzker, R., Böhmer, F.D. Nat. Rev. Mol. Cell Biol. (2003)
- CXCR4 physically associates with the T cell receptor to signal in T cells. Kumar, A., Humphreys, T.D., Kremer, K.N., Bramati, P.S., Bradfield, L., Edgar, C.E., Hedin, K.E. Immunity (2006)
- Molecular characterization and chromosomal localization of DRT (EPHT3): a developmentally regulated human protein-tyrosine kinase gene of the EPH family. Ikegaki, N., Tang, X.X., Liu, X.G., Biegel, J.A., Allen, C., Yoshioka, A., Sulman, E.P., Brodeur, G.M., Pleasure, D.E. Hum. Mol. Genet. (1995)
- Isoflurane preconditioning protects human neuroblastoma SH-SY5Y cells against in vitro simulated ischemia-reperfusion through the activation of extracellular signal-regulated kinases pathway. Zuo, Z., Wang, Y., Huang, Y. Eur. J. Pharmacol. (2006)
- The adhesion molecule L1 (CD171) promotes melanoma progression. Meier, F., Busch, S., Gast, D., Göppert, A., Altevogt, P., Maczey, E., Riedle, S., Garbe, C., Schittek, B. Int. J. Cancer (2006)
- Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors. Alazzouzi, H., Davalos, V., Kokko, A., Domingo, E., Woerner, S.M., Wilson, A.J., Konrad, L., Laiho, P., Espín, E., Armengol, M., Imai, K., Yamamoto, H., Mariadason, J.M., Gebert, J.F., Aaltonen, L.A., Schwartz, S., Arango, D. Cancer Res. (2005)
- Enamel Matrix Derivative Stimulates Human Gingival Fibroblast Proliferation via ERK. Zeldich, E., Koren, R., Nemcovsky, C., Weinreb, M. J. Dent. Res. (2007)
- Chloramphenicol induces in vitro growth arrest and apoptosis of human keratinocytes. Popadic, S., Popadic, D., Ramic, Z., Stojkovic, M.M., Trajkovic, V., Milinkovic, M., Medenica, L. Cell Biol. Toxicol. (2006)
- Thrombin stimulation of p38 MAP kinase in human platelets is mediated by ADP and thromboxane A2 and inhibited by cGMP/cGMP-dependent protein kinase. Begonja, A.J., Geiger, J., Rukoyatkina, N., Rauchfuss, S., Gambaryan, S., Walter, U. Blood (2007)
- Receptor tyrosine kinase (RTK) inhibition is effective in chemosensitising EGFR-expressing drug resistant human ovarian cancer cell lines when used in combination with cytotoxic agents. Coley, H.M., Shotton, C.F., Ajose-Adeogun, A., Modjtahedi, H., Thomas, H. Biochem. Pharmacol. (2006)
- Ca2+-sensing receptor induces Rho kinase-mediated actin stress fiber assembly and altered cell morphology, but not in response to aromatic amino acids. Davies, S.L., Gibbons, C.E., Vizard, T., Ward, D.T. Am. J. Physiol., Cell Physiol. (2006)
- The HSV-2 protein ICP10PK prevents neuronal apoptosis and loss of function in an in vivo model of neurodegeneration associated with glutamate excitotoxicity. Golembewski, E.K., Wales, S.Q., Aurelian, L., Yarowsky, P.J. Exp. Neurol. (2007)
- Antiproliferative effect of sildenafil on human pulmonary artery smooth muscle cells. Tantini, B., Manes, A., Fiumana, E., Pignatti, C., Guarnieri, C., Zannoli, R., Md, A.B., Galiè, N. Basic Res. Cardiol. (2005)
- Association among EPHB2, TrkA, and MYCN expression in low-stage neuroblastomas. Tang, X.X., Evans, A.E., Zhao, H., Cnaan, A., Brodeur, G.M., Ikegaki, N. Med. Pediatr. Oncol. (2001)
- A mutation in RYK is a genetic factor for nonsyndromic cleft lip and palate. Watanabe, A., Akita, S., Tin, N.T., Natsume, N., Nakano, Y., Niikawa, N., Uchiyama, T., Yoshiura, K. Cleft Palate Craniofac. J. (2006)
- Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors. Kiyokawa, E., Takai, S., Tanaka, M., Iwase, T., Suzuki, M., Xiang, Y.Y., Naito, Y., Yamada, K., Sugimura, H., Kino, I. Cancer Res. (1994)
- (+/-)-2-Chloropropionic acid elevates reactive oxygen species formation in human neutrophil granulocytes. Aam, B.B., Fonnum, F. Toxicology (2006)
- Inhibition of Tumor Endothelial ERK Activation, Angiogenesis, and Tumor Growth by Sorafenib (BAY43-9006). Murphy, D.A., Makonnen, S., Lassoued, W., Feldman, M.D., Carter, C., Lee, W.M. Am. J. Pathol. (2006)
- ERK binds, phosphorylates InsP3 type 1 receptor and regulates intracellular calcium dynamics in DT40 cells. Yang, L.H., Bai, G.R., Huang, X.Y., Sun, F.Z. Biochem. Biophys. Res. Commun. (2006)