The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Slc1a6  -  solute carrier family 1 (high affinity...

Mus musculus

Synonyms: EAAT4, Eaat4, Excitatory amino acid transporter 4, High-affinity neuronal glutamate transporter, Sodium-dependent glutamate/aspartate transporter, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Slc1a6

  • Nonsynaptic localization of the excitatory amino acid transporter 4 in photoreceptors [1].
  • In the GLAST-deficient mice, however, the application of cyclothiazide that reduces desensitization of AMPA receptors increased the peak amplitude of the EPSC and prolonged its decay more markedly than in both wild-type and EAAT4-deficient mice [2].
  • However, long-lasting tail currents of the EPSCs appeared age dependently in most of Purkinje cells in EAAT4-deficient mice [2].
  • In contrast, the main role of EAAT4 is to remove low concentrations of glutamate that escape from the uptake by glial transporters at late times and thus prevents the transmitter from spilling over to neighboring synapses [2].
  • To clarify the functional significance of the coexistence of these transporters, we analyzed the kinetics of EPSCs in Purkinje cells of mice lacking either GLAST or EAAT4 [2].
 

Biological context of Slc1a6

  • There was no difference in the amplitude or the kinetics of the rising and initial decay phase of EPSCs evoked by stimulations of climbing fibers and parallel fibers between wild-type and EAAT4-deficient mice [2].
 

Anatomical context of Slc1a6

References

  1. Nonsynaptic localization of the excitatory amino acid transporter 4 in photoreceptors. Pignataro, L., Sitaramayya, A., Finnemann, S.C., Sarthy, V.P. Mol. Cell. Neurosci. (2005) [Pubmed]
  2. Differential roles of glial and neuronal glutamate transporters in Purkinje cell synapses. Takayasu, Y., Iino, M., Kakegawa, W., Maeno, H., Watase, K., Wada, K., Yanagihara, D., Miyazaki, T., Komine, O., Watanabe, M., Tanaka, K., Ozawa, S. J. Neurosci. (2005) [Pubmed]
 
WikiGenes - Universities