Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

SENP5 - SUMO1/sentrin specific peptidase 5

Homo sapiens

Synonyms: FKSG45, MGC27076, Sentrin-specific protease 5, Sentrin/SUMO-specific protease SENP5

Gong, L. et al., Di Bacco, A. et al., Zunino, R. et al., Di Bacco, A. et al.

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High impact information on SENP5

The SUMO-specific protease SENP5 is required for cell division [1].
Nonetheless, SENP5 could remove SUMO-1, -2, and -3 from the Lys65 position of PML [2].
SENP5 showed SUMO-3 C-terminal hydrolase activity but could not process pro-SUMO-1 in vitro [2].
We were also able to show that SENP3 has substrate specificity similar to that of SENP5 [2].
Here, we have described SENP5, which has restricted substrate specificity [2].

Biological context of SENP5

Overexpression of SENP5 rescues SUMO1-induced mitochondrial fragmentation that is partly due to the downregulation of DRP1 [3].
Furthermore, our finding of a nonredundant function for SENP5 in cell proliferation provides further support for the model that, analogous to phosphorylation, cycles of SUMOylation and deSUMOylation regulate orderly progression through cell division [4].
SUMO-specific proteases and the cell cycle. An essential role for SENP5 in cell proliferation [4].

Other interactions of SENP5

Thus, SENP5 also possesses limited SUMO-1 isopeptidase activity [2].

References

The SUMO-specific protease SENP5 is required for cell division. Di Bacco, A., Ouyang, J., Lee, H.Y., Catic, A., Ploegh, H., Gill, G. Mol. Cell. Biol. (2006) [Pubmed]
Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. Gong, L., Yeh, E.T. J. Biol. Chem. (2006) [Pubmed]
The SUMO protease SENP5 is required to maintain mitochondrial morphology and function. Zunino, R., Schauss, A., Rippstein, P., Andrade-Navarro, M., McBride, H.M. J. Cell. Sci. (2007) [Pubmed]
SUMO-specific proteases and the cell cycle. An essential role for SENP5 in cell proliferation. Di Bacco, A., Gill, G. Cell Cycle (2006) [Pubmed]

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