Gene Review:
EPS8 - epidermal growth factor receptor pathway...
Homo sapiens
Synonyms:
Epidermal growth factor receptor kinase substrate 8
- IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness. Funato, Y., Terabayashi, T., Suenaga, N., Seiki, M., Takenawa, T., Miki, H. Cancer Res. (2004)
- Combined cDNA array comparative genomic hybridization and serial analysis of gene expression analysis of breast tumor progression. Yao, J., Weremowicz, S., Feng, B., Gentleman, R.C., Marks, J.R., Gelman, R., Brennan, C., Polyak, K. Cancer Res. (2006)
- The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5. Lanzetti, L., Rybin, V., Malabarba, M.G., Christoforidis, S., Scita, G., Zerial, M., Di Fiore, P.P. Nature (2000)
- EPS8 and E3B1 transduce signals from Ras to Rac. Scita, G., Nordstrom, J., Carbone, R., Tenca, P., Giardina, G., Gutkind, S., Bjarnegård, M., Betsholtz, C., Di Fiore, P.P. Nature (1999)
- Domain swapping is a consequence of minimal frustration. Yang, S., Cho, S.S., Levy, Y., Cheung, M.S., Levine, H., Wolynes, P.G., Onuchic, J.N. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Evolutionary conservation of the EPS8 gene and its mapping to human chromosome 12q23-q24. Wong, W.T., Carlomagno, F., Druck, T., Barletta, C., Croce, C.M., Huebner, K., Kraus, M.H., Di Fiore, P.P. Oncogene (1994)
- Constitutive phosphorylation of eps8 in tumor cell lines: relevance to malignant transformation. Matoskova, B., Wong, W.T., Salcini, A.E., Pelicci, P.G., Di Fiore, P.P. Mol. Cell. Biol. (1995)
- Immunohistochemical markers in diagnosis of papillary thyroid carcinoma: utility of HBME1 combined with CK19 immunostaining. Nasr, M.R., Mukhopadhyay, S., Zhang, S., Katzenstein, A.L. Mod. Pathol. (2006)
- Expression of the receptor tyrosine kinase substrate genes eps8 and eps15 during mouse development. Avantaggiato, V., Torino, A., Wong, W.T., Di Fiore, P.P., Simeone, A. Oncogene (1995)
- Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Calderwood, D.A., Fujioka, Y., de Pereda, J.M., García-Alvarez, B., Nakamoto, T., Margolis, B., McGlade, C.J., Liddington, R.C., Ginsberg, M.H. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein. Miyazaki, K., Matsuda, S., Ichigotani, Y., Takenouchi, Y., Hayashi, K., Fukuda, Y., Nimura, Y., Hamaguchi, M. Biochim. Biophys. Acta (2000)
- Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells. Goicoechea, S., Arneman, D., Disanza, A., Garcia-Mata, R., Scita, G., Otey, C.A. J. Cell. Sci. (2006)
- Direct binding of eps8 to the juxtamembrane domain of EGFR is phosphotyrosine- and SH2-independent. Castagnino, P., Biesova, Z., Wong, W.T., Fazioli, F., Gill, G.N., Di Fiore, P.P. Oncogene (1995)
- Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking. Burke, P., Schooler, K., Wiley, H.S. Mol. Biol. Cell (2001)
- Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins. Karlsson, T., Songyang, Z., Landgren, E., Lavergne, C., Di Fiore, P.P., Anafi, M., Pawson, T., Cantley, L.C., Claesson-Welsh, L., Welsh, M. Oncogene (1995)
- Epidermal growth factor receptor pathway substrate 8 (Eps8) expression in maturing testis. Wunsch, A., Strothmann, K., Simoni, M., Gromoll, J., Nieschlag, E., Luetjens, C.M. Asian J. Androl. (2004)