Gene Review:
Sst - somatostatin
Mus musculus
Synonyms:
SOM, SRIF, SS, Smst, Somatostatin, ...
- Somatostatin inhibits multireceptor stimulation of cyclic AMP formation and corticotropin secretion in mouse pituitary tumor cells. Heisler, S., Reisine, T.D., Hook, V.Y., Axelrod, J. Proc. Natl. Acad. Sci. U.S.A. (1982)
- Substance P modulates antigen-induced, IFN-gamma production in murine Schistosomiasis mansoni. Blum, A.M., Metwali, A., Cook, G., Mathew, R.C., Elliott, D., Weinstock, J.V. J. Immunol. (1993)
- Mutation of an aspartate at residue 89 in somatostatin receptor subtype 2 prevents Na+ regulation of agonist binding but does not alter receptor-G protein association. Kong, H., Raynor, K., Yasuda, K., Bell, G.I., Reisine, T. Mol. Pharmacol. (1993)
- Gene therapy for pancreatic carcinoma: local and distant antitumor effects after somatostatin receptor sst2 gene transfer. Rochaix, P., Delesque, N., Estève, J.P., Saint-Laurent, N., Voight, J.J., Vaysse, N., Susini, C., Buscail, L. Hum. Gene Ther. (1999)
- Human ovarian cancers express somatostatin receptors. Halmos, G., Sun, B., Schally, A.V., Hebert, F., Nagy, A. J. Clin. Endocrinol. Metab. (2000)
- Recovery and measurement of specific RNA species from postmortem brain tissue: a general reduction in Alzheimer's disease detected by molecular hybridization. Taylor, G.R., Carter, G.I., Crow, T.J., Johnson, J.A., Fairbairn, A.F., Perry, E.K., Perry, R.H. Exp. Mol. Pathol. (1986)
- Cortistatin overexpression in transgenic mice produces deficits in synaptic plasticity and learning. Tallent, M.K., Fabre, V., Qiu, C., Calbet, M., Lamp, T., Baratta, M.V., Suzuki, C., Levy, C.L., Siggins, G.R., Henriksen, S.J., Criado, J.R., Roberts, A., de Lecea, L. Mol. Cell. Neurosci. (2005)
- Somatostatin content increases following norepinephrine depletion in frontal cortex of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice. Mitsuo, K., Schwartz, J.P. J. Neurochem. (1992)
- Cortistatin and somatostatin mRNAs are differentially regulated in response to kainate. Calbet, M., Guadaño-Ferraz, A., Spier, A.D., Maj, M., Sutcliffe, J.G., Przewłocki, R., de Lecea, L. Brain Res. Mol. Brain Res. (1999)
- Effect of somatostatin and its antagonist on morphine analgesia in mice. Capasso, A. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1999)
- Tissue-specific posttranslational processing of pre-prosomatostatin encoded by a metallothionein-somatostatin fusion gene in transgenic mice. Low, M.J., Hammer, R.E., Goodman, R.H., Habener, J.F., Palmiter, R.D., Brinster, R.L. Cell (1985)
- Letter: Somatostatin, growth hormone and parkinsonism. Cotzias, G.C., Papavasiliou, P.S. N. Engl. J. Med. (1976)
- Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation. Saito, T., Iwata, N., Tsubuki, S., Takaki, Y., Takano, J., Huang, S.M., Suemoto, T., Higuchi, M., Saido, T.C. Nat. Med. (2005)
- NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Kojima, H., Fujimiya, M., Matsumura, K., Younan, P., Imaeda, H., Maeda, M., Chan, L. Nat. Med. (2003)
- Sequential expression of the neuropeptides substance P and somatostatin in granulomas associated with murine cysticercosis. Robinson, P., White, A.C., Lewis, D.E., Thornby, J., David, E., Weinstock, J. Infect. Immun. (2002)
- Somatostatin receptor subtypes sst1 and sst2 elicit opposite effects on the response to glutamate of mouse hypothalamic neurones: an electrophysiological and single cell RT-PCR study. Lanneau, C., Viollet, C., Faivre-Bauman, A., Loudes, C., Kordon, C., Epelbaum, J., Gardette, R. Eur. J. Neurosci. (1998)
- Somatostatin receptors in wildtype and somatostatin deficient mice and their involvement in nitric oxide physiology in the retina. Mastrodimou, N., Vasilaki, A., Papadioti, A., Low, M.J., Hoyer, D., Thermos, K. Neuropeptides (2006)
- Thyroid hormone-responsive pituitary hyperplasia independent of somatostatin receptor 2. Brinkmeier, M.L., Stahl, J.H., Gordon, D.F., Ross, B.D., Sarapura, V.D., Dowding, J.M., Kendall, S.K., Lloyd, R.V., Ridgway, E.C., Camper, S.A. Mol. Endocrinol. (2001)
- Induction of a negative autocrine loop by expression of sst2 somatostatin receptor in NIH 3T3 cells. Rauly, I., Saint-Laurent, N., Delesque, N., Buscail, L., Estéve, J.P., Vaysse, N., Susini, C. J. Clin. Invest. (1996)
- Selective expression of neuropeptides in the rat mammary gland: somatostatin gene is expressed during lactation. Chen, A., Laskar-Levy, O., Koch, Y. Endocrinology (1999)
- Somatostatin activates two types of inwardly rectifying K+ channels in MIN-6 cells. Smith, P.A., Sellers, L.A., Humphrey, P.P. J. Physiol. (Lond.) (2001)
- Evidence that endogenous SST inhibits ACTH and ghrelin expression by independent pathways. Luque, R.M., Gahete, M.D., Hochgeschwender, U., Kineman, R.D. Am. J. Physiol. Endocrinol. Metab. (2006)
- Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes. Gong, A.Y., Tietz, P.S., Muff, M.A., Splinter, P.L., Huebert, R.C., Strowski, M.Z., Chen, X.M., LaRusso, N.F. Am. J. Physiol., Cell Physiol. (2003)
- High basal gastric acid secretion in somatostatin receptor subtype 2 knockout mice. Martinez, V., Curi, A.P., Torkian, B., Schaeffer, J.M., Wilkinson, H.A., Walsh, J.H., Taché, Y. Gastroenterology (1998)
- Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor. Upchurch, B.H., Aponte, G.W., Leiter, A.B. Development (1994)
- Somatostatin is expressed in the murine thymus and enhances thymocyte development. Solomou, K., Ritter, M.A., Palmer, D.B. Eur. J. Immunol. (2002)
- Sexually dimorphic distribution of sst2A somatostatin receptors on growth hormone-releasing hormone neurons in mice. Bouyer, K., Loudes, C., Robinson, I.C., Epelbaum, J., Faivre-Bauman, A. Endocrinology (2006)
- Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells. Vieira, E., Salehi, A., Gylfe, E. Diabetologia (2007)
- Somatostatin inhibits corticotropin-releasing factor-stimulated adrenocorticotropin release, adenylate cyclase, and activation of adenosine 3',5'-monophosphate-dependent protein kinase isoenzymes in AtT20 cells. Litvin, Y., Leiser, M., Fleischer, N., Erlichman, J. Endocrinology (1986)
- R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion. Zhang, Q., Bengtsson, M., Partridge, C., Salehi, A., Braun, M., Cox, R., Eliasson, L., Johnson, P.R., Renström, E., Schneider, T., Berggren, P.O., Göpel, S., Ashcroft, F.M., Rorsman, P. Nat. Cell Biol. (2007)
- Differential expression of somatostatin receptor subtypes in brain. Breder, C.D., Yamada, Y., Yasuda, K., Seino, S., Saper, C.B., Bell, G.I. J. Neurosci. (1992)
- Hormone inhibition of adenylyl cyclase. Differences in the mechanisms for inhibition by hormones and G protein beta gamma. Hildebrandt, J.D., Kohnken, R.E. J. Biol. Chem. (1990)
- Somatostatin receptors on cortical neurones and adenohypophysis: comparison between specific binding and adenylate cyclase inhibition. Chneiweiss, H., Bertrand, P., Epelbaum, J., Kordon, C., Glowinski, J., Premont, J., Enjalbert, A. Eur. J. Pharmacol. (1987)
- Galanin inhibits gastric acid secretion through a somatostatin-independent mechanism in mice. Piqueras, L., Taché, Y., Martinez, V. Peptides (2004)
- Influences of gastro-intestinal polypeptides and glucose on glucagon secretion induced by cholinergic stimulation. Ahrén, B., Lundquist, I. Horm. Metab. Res. (1982)
- Interaction of glucagon-like peptide-I (7-37) and somatostatin-14 on signal transduction and proinsulin gene expression in beta TC-1 cells. Fehmann, H.C., Strowski, M., Göke, B. Metab. Clin. Exp. (1994)
- Somatostatin controls LFA-1 gene expression by altering neuraminidase expression in spleen cells. Yoon, W.K., Kim, H.J., Son, H.Y., Jeong, K.S., Park, S.J., Kim, T.H., Kim, S.H., Kim, S.R., Ryu, S.Y. Anticancer Res. (2004)
- Targeted oncogenesis of hormone-negative pancreatic islet progenitor cells. Jetton, T.L., Moates, J.M., Lindner, J., Wright, C.V., Magnuson, M.A. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Neurons derived from P19 embryonal carcinoma cells have varied morphologies and neurotransmitters. Staines, W.A., Morassutti, D.J., Reuhl, K.R., Ally, A.I., McBurney, M.W. Neuroscience (1994)
- Mouse cortical inhibitory neuron type that coexpresses somatostatin and calretinin. Xu, X., Roby, K.D., Callaway, E.M. J. Comp. Neurol. (2006)