The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.
wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review: 

Serpina1d  -  serine (or cysteine) peptidase inhibitor,...

Mus musculus

Synonyms: AI118301, Alpha-1 protease inhibitor 4, Alpha-1-antitrypsin 1-4, Dom4, PI4, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Serpina1d

  • The effect of NCS-1 on exocytosis is mediated through an increase in phosphatidylinositol (PI) 4-kinase beta activity and the generation of phosphoinositides, specifically PI 4-phosphate and PI 4,5-bisphosphate [1].
  • We conclude that ADP-induced changes in PI 4-kinase activity, via generation of PI(4,5)P(2), represents a metabolic sensor in the beta cell by virtue of its capacity to regulate the release competence of the secretory granules [2].
  • It has previously been shown that PI3-kinase and PI4-kinase enzymes regulate neuronal survival and the retrograde axonal transport of nerve growth factor in sympathetic and sensory neurons [3].
  • Phenylarsine oxide (PAO), a PI4-kinase antagonist, significantly inhibited (125)I-NT-4 retrograde axonal transport in sympathetic and sensory neurons [3].
  • Experiments with quinacrine and adenosine confirmed that PI-PLC and PI 4-kinase could be regulated independently of each other [4].
 

Biological context of Serpina1d

  • Reducing the cytoplasmic ADP concentration in a way mimicking the effects of glucose stimulation activated PI 4-kinase and increased exocytosis whereas changes of the ATP concentration in the physiological range had little effect [2].

References

  1. Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic beta cells through activation of phosphatidylinositol 4-kinase beta. Gromada, J., Bark, C., Smidt, K., Efanov, A.M., Janson, J., Mandic, S.A., Webb, D.L., Zhang, W., Meister, B., Jeromin, A., Berggren, P.O. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells. Olsen, H.L., Hoy, M., Zhang, W., Bertorello, A.M., Bokvist, K., Capito, K., Efanov, A.M., Meister, B., Thams, P., Yang, S.N., Rorsman, P., Berggren, P.O., Gromada, J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Phosphatidylinositol kinase enzymes regulate the retrograde axonal transport of NT-3 and NT-4 in sympathetic and sensory neurons. Bartlett, S.E., Reynolds, A.J., Weible, M., Hendry, I.A. J. Neurosci. Res. (2002) [Pubmed]
  4. Carbamoylcholine regulation of polyphosphoinositide synthesis and hydrolysis in cultured, dispersed, digitonin-permeabilized mouse pancreatic islet cells. Kardasz, A.M., Thams, P., Capito, K., Hedeskov, C.J. Eur. J. Endocrinol. (1997) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Use
 

Editor

Share

Personal info

View

Links

Table of contents

About

Terms

 

WikiGenes - Universities