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Suv39h1  -  suppressor of variegation 3-9 homolog 1...

Mus musculus

Synonyms: AI852103, AL022883, DXHXS7466e, H3-K9-HMTase 1, Histone H3-K9 methyltransferase 1, ...
 
 
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Disease relevance of Suv39h1

  • These results identify H3K9me-mediated senescence as a novel Suv39h1-dependent tumour suppressor mechanism whose inactivation permits the formation of aggressive but apoptosis-competent lymphomas in response to oncogenic Ras [1].
 

High impact information on Suv39h1

  • Taken together, the results indicate epigenetic regulation of telomere length in mammals by Suv39h1 and Suv39h2 [2].
  • Disruption of the two mouse Suv39h HMTases abolishes H3-Lys9 methylation of constitutive heterochromatin but not that of the Xi [3].
  • Suv39h-deficient mice display severely impaired viability and chromosomal instabilities that are associated with an increased tumor risk and perturbed chromosome interactions during male meiosis [4].
  • These in vivo data assign a crucial role for pericentric H3-K9 methylation in protecting genome stability, and define the Suv39h HMTases as important epigenetic regulators for mammalian development [4].
  • Here we show that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins--a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure [5].
 

Chemical compound and disease context of Suv39h1

 

Biological context of Suv39h1

 

Anatomical context of Suv39h1

  • These data are consistent with redundant enzymatic roles for Suv39h1 and Suv39h2 during mouse development and suggest an additional function of the Suv39h2 HMTase in organizing meiotic heterochromatin that may even impart an epigenetic imprint to the male germ line [7].
  • Proliferation of primary lymphocytes is directly stalled by a Suv39h1-dependent, H3K9me-related senescent growth arrest in response to oncogenic Ras, thereby cancelling lymphomagenesis at an initial step [1].
  • Additionally, B cells from Suv39h1-deficient mice have an isotype-specific reduction in IgA switching with no effect on the level of germline Ialpha-Calpha transcripts [9].
  • In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after the re-introduction of a catalytically active SWUV39H1 HMTase [5].
  • Finally, Suv39h-depleted myoblasts were unable to express early or late muscle differentiation markers [10].
 

Physical interactions of Suv39h1

  • Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression [11].
 

Regulatory relationships of Suv39h1

 

Other interactions of Suv39h1

  • This repression required Suv39h1 association with MyoD as well as sustained methylation of H3-K9 on myogenin promoter [12].
  • G9a-deficient ES cells also exhibited reduced H3-K9 methylation compared to wild-type cells, indicating that G9a is a dominant H3-K9 HMTase in vivo [13].
  • Analysis of mice deficient for A-type lamins, histone H2AX, Suv39h HMTases, and the AE protein SYCP3 suggests that entry into prophase I requires heterochromatin integrity and lamin A expression [14].

References

  1. Oncogene-induced senescence as an initial barrier in lymphoma development. Braig, M., Lee, S., Loddenkemper, C., Rudolph, C., Peters, A.H., Schlegelberger, B., Stein, H., Dörken, B., Jenuwein, T., Schmitt, C.A. Nature (2005) [Pubmed]
  2. Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. García-Cao, M., O'Sullivan, R., Peters, A.H., Jenuwein, T., Blasco, M.A. Nat. Genet. (2004) [Pubmed]
  3. Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin. Peters, A.H., Mermoud, J.E., O'Carroll, D., Pagani, M., Schweizer, D., Brockdorff, N., Jenuwein, T. Nat. Genet. (2002) [Pubmed]
  4. Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Peters, A.H., O'Carroll, D., Scherthan, H., Mechtler, K., Sauer, S., Schöfer, C., Weipoltshammer, K., Pagani, M., Lachner, M., Kohlmaier, A., Opravil, S., Doyle, M., Sibilia, M., Jenuwein, T. Cell (2001) [Pubmed]
  5. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., Jenuwein, T. Nature (2001) [Pubmed]
  6. Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. Aagaard, L., Laible, G., Selenko, P., Schmid, M., Dorn, R., Schotta, G., Kuhfittig, S., Wolf, A., Lebersorger, A., Singh, P.B., Reuter, G., Jenuwein, T. EMBO J. (1999) [Pubmed]
  7. Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression. O'Carroll, D., Scherthan, H., Peters, A.H., Opravil, S., Haynes, A.R., Laible, G., Rea, S., Schmid, M., Lebersorger, A., Jerratsch, M., Sattler, L., Mattei, M.G., Denny, P., Brown, S.D., Schweizer, D., Jenuwein, T. Mol. Cell. Biol. (2000) [Pubmed]
  8. Cathepsin L stabilizes the histone modification landscape on the Y chromosome and pericentromeric heterochromatin. Bulynko, Y.A., Hsing, L.C., Mason, R.W., Tremethick, D.J., Grigoryev, S.A. Mol. Cell. Biol. (2006) [Pubmed]
  9. The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA. Bradley, S.P., Kaminski, D.A., Peters, A.H., Jenuwein, T., Stavnezer, J. J. Immunol. (2006) [Pubmed]
  10. A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells. Ait-Si-Ali, S., Guasconi, V., Fritsch, L., Yahi, H., Sekhri, R., Naguibneva, I., Robin, P., Cabon, F., Polesskaya, A., Harel-Bellan, A. EMBO J. (2004) [Pubmed]
  11. Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression. Frontelo, P., Leader, J.E., Yoo, N., Potocki, A.C., Crawford, M., Kulik, M., Lechleider, R.J. Oncogene (2004) [Pubmed]
  12. Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation. Mal, A.K. EMBO J. (2006) [Pubmed]
  13. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Tachibana, M., Sugimoto, K., Nozaki, M., Ueda, J., Ohta, T., Ohki, M., Fukuda, M., Takeda, N., Niida, H., Kato, H., Shinkai, Y. Genes Dev. (2002) [Pubmed]
  14. Knockout mice provide novel insights into meiotic chromosome and telomere dynamics. Scherthan, H. Cytogenet. Genome Res. (2003) [Pubmed]
 
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