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Gene Review

EVX1  -  even-skipped homeobox 1

Homo sapiens

Synonyms: EVX-1, Homeobox even-skipped homolog protein 1
 
 
 
 
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High impact information on EVX1

  • Transcriptional repression by the human homeobox protein EVX1 in transfected mammalian cells [1].
  • EVX1 expression represses transcription of a reporter gene directed by either cell-specific or viral promoter/enhancer sequences in a variety of mammalian cell lines and in a concentration-dependent manner [1].
  • We speculate that the repressor function of EVX1 contributes to its proposed role in embryogenesis [1].
  • A carboxyl-terminal proline/alanine-rich region of EVX1 seems to be responsible for the transcriptional repression activity, as suggested by transfection of EVX1 mutants [1].

References

  1. Transcriptional repression by the human homeobox protein EVX1 in transfected mammalian cells. Briata, P., Van De Werken, R., Airoldi, I., Ilengo, C., Di Blas, E., Boncinelli, E., Corte, G. J. Biol. Chem. (1995) [Pubmed]
 
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