The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Tbp  -  TATA box binding protein

Mus musculus

Synonyms: GTF2D1, Gtf2d, SCA17, TATA sequence-binding protein, TATA-binding factor, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Tbp

  • Recently, an inherited spinocerebellar ataxia (SCA17) has been attributed to polyglutamine coding expansions within the gene coding for human TATA-box binding protein (TBP) [1].
  • Neither Hyb protein, however, disrupts the nuclear entry of the EHV-1 immediate-early, IR4, or UL5 proteins or cellular TATA box binding protein (TBP) previously shown to interact with both IR4 or UL5 in productive infection [2].
 

High impact information on Tbp

  • We demonstrate that both gene-specific activator protein Sp1 and selective components of the core transcription apparatus, including TFIID and TFIIF, are direct targets inhibited by mutant htt in a polyglutamine-dependent manner [3].
  • Here, we report that the tissue-selective TAFII105 subunit of TFIID is essential for proper development and function of the mouse ovary [4].
  • Maintenance of spermatogenesis requires TAF4b, a gonad-specific subunit of TFIID [5].
  • The gonad-specific TAF4b component of TFIID (formerly TAF(II)105) is a transcriptional regulator enriched in the mouse testis [5].
  • We have inactivated transcription factor TFIID subunit TBP-associated factor 4 (TAF4) in mouse embryonic fibroblasts [6].
 

Biological context of Tbp

  • Interestingly, after mitosis, reimport of TRF3 into the nucleus occurs subsequent to TBP and other basal transcription factors [7].
  • Thus, our results demonstrate that TAF10 is required for TFIID stability, cell cycle progression, and transcription in the early mouse embryo [8].
  • TAF10 (TAF(II)30) is necessary for TFIID stability and early embryogenesis in mice [8].
  • Developmental specificity of recruitment of TBP to the TATA box of the human gamma-globin gene [9].
  • A complementary DNA (cDNA) encoding a mouse TFIID (mIID) was isolated from mouse brain cDNA libraries [10].
 

Anatomical context of Tbp

 

Associations of Tbp with chemical compounds

  • In particular, we found that the mouse TAF(II)30 subunit of the TFIID initiation complex is markedly accumulated in NIs, even though this protein does not contain a polyglutamine stretch [15].
  • The promoter-specific transcription factor Sp1 contains two glutamine-rich transcriptional activation domains (A and B) that mediate direct interactions with the transcription factor TFIID complex associated with RNA polymerase II and synergistic effects involving multiple Sp1 molecules [16].
  • In addition, the Tf-binding protein (Tbp) from strain B31 retained the ability to bind Tf after treatment with 2% sodium dodecyl sulfate-1% beta-mercaptoethanol and heating to 100 degrees C for 5 min [17].
  • Further our results indicated that shikonin suppressed the basal transcription and activator-regulated transcription of TNF-alpha by inhibiting the binding of transcription factor IID protein complex (TATA box-binding protein) to TATA box [18].
  • Among these factors are the steroid receptor, nuclear factor I (NFI) and the TATA box factor (TFIID) [19].
 

Physical interactions of Tbp

  • Identification of the 40-kDa protein as the TATA-binding protein (TBP) of the TFIID transcription initiation complex was made by comigration and V-8 protease mapping, which yielded identical peptide fragments upon digestion of the 40-kDa protein and material immunoprecipitated with an anti-TBP specific antibody [20].
 

Other interactions of Tbp

  • These are Tbp and D17Ph4e [21].
  • Chromatin immunoprecipitation analysis reveals that NF-Y is required for the recruitment of RNA polymerase II (RNAPII) and TATA box binding protein on the ODF promoter [22].
  • The triple substitution had no apparent effects on intracellular accumulation or localization of p53, oligomerization, DNA binding, or interaction with the TFIID TATA-binding protein [23].
  • We conclude that the alpha-SG promoter is activated by MyoD, which interacts with TFIID and TFIIB in a protein complex differentially located at the distal promoter and around the proximal promoter during myogenic cell differentiation [14].
  • Our studies show that the TATA-binding protein of TFIID is required for initiation of transcription from the GATA box-containing promoters [24].
 

Analytical, diagnostic and therapeutic context of Tbp

References

  1. Molecular investigation of TBP allele length: a SCA17 cellular model and population study. Reid, S.J., Rees, M.I., van Roon-Mom, W.M., Jones, A.L., MacDonald, M.E., Sutherland, G., During, M.J., Faull, R.L., Owen, M.J., Dragunow, M., Snell, R.G. Neurobiol. Dis. (2003) [Pubmed]
  2. Genetic complexity of EHV-1 defective interfering particles and identification of novel IR4/UL5 hybrid proteins produced during persistent infection. Ebner, P.D., O'Callaghan, D.J. Virus Genes (2006) [Pubmed]
  3. In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets. Zhai, W., Jeong, H., Cui, L., Krainc, D., Tjian, R. Cell (2005) [Pubmed]
  4. Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development. Freiman, R.N., Albright, S.R., Zheng, S., Sha, W.C., Hammer, R.E., Tjian, R. Science (2001) [Pubmed]
  5. Maintenance of spermatogenesis requires TAF4b, a gonad-specific subunit of TFIID. Falender, A.E., Freiman, R.N., Geles, K.G., Lo, K.C., Hwang, K., Lamb, D.J., Morris, P.L., Tjian, R., Richards, J.S. Genes Dev. (2005) [Pubmed]
  6. TAF4 inactivation in embryonic fibroblasts activates TGF beta signalling and autocrine growth. Mengus, G., Fadloun, A., Kobi, D., Thibault, C., Perletti, L., Michel, I., Davidson, I. EMBO J. (2005) [Pubmed]
  7. TRF3, a TATA-box-binding protein-related factor, is vertebrate-specific and widely expressed. Persengiev, S.P., Zhu, X., Dixit, B.L., Maston, G.A., Kittler, E.L., Green, M.R. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  8. TAF10 (TAF(II)30) is necessary for TFIID stability and early embryogenesis in mice. Mohan, W.S., Scheer, E., Wendling, O., Metzger, D., Tora, L. Mol. Cell. Biol. (2003) [Pubmed]
  9. Developmental specificity of recruitment of TBP to the TATA box of the human gamma-globin gene. Duan, Z.J., Fang, X., Rohde, A., Han, H., Stamatoyannopoulos, G., Li, Q. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  10. Striking homology of the 'variable' N-terminal as well as the 'conserved core' domains of the mouse and human TATA-factors (TFIID). Tamura, T., Sumita, K., Fujino, I., Aoyama, A., Horikoshi, M., Hoffmann, A., Roeder, R.G., Muramatsu, M., Mikoshiba, K. Nucleic Acids Res. (1991) [Pubmed]
  11. Transcription factor IID probes localize a single gene to the proximal region of mouse chromosome 17. Danciger, M., Kozak, C.A., Suzuki, S., Chang, M.R., Shinohara, T., Farber, D.B. Gene (1993) [Pubmed]
  12. Regulation of gene expression in the mouse oocyte and early preimplantation embryo: developmental changes in Sp1 and TATA box-binding protein, TBP. Worrad, D.M., Ram, P.T., Schultz, R.M. Development (1994) [Pubmed]
  13. The murine adenosine deaminase promoter requires an atypical TATA box which binds transcription factor IID and transcriptional activity is stimulated by multiple upstream Sp1 binding sites. Innis, J.W., Moore, D.J., Kash, S.F., Ramamurthy, V., Sawadogo, M., Kellems, R.E. J. Biol. Chem. (1991) [Pubmed]
  14. Partial characterization of the mouse alpha-sarcoglycan promoter and its responsiveness to MyoD. Delgado-Olguín, P., Recillas-Targa, F., Rosas-Vargas, H., Salamanca, F., Coral-Vázquez, R.M. Biochim. Biophys. Acta (2006) [Pubmed]
  15. SCA7 mouse models show selective stabilization of mutant ataxin-7 and similar cellular responses in different neuronal cell types. Yvert, G., Lindenberg, K.S., Devys, D., Helmlinger, D., Landwehrmeyer, G.B., Mandel, J.L. Hum. Mol. Genet. (2001) [Pubmed]
  16. An alternatively spliced form of the transcription factor Sp1 containing only a single glutamine-rich transactivation domain. Persengiev, S.P., Saffer, J.D., Kilpatrick, D.L. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  17. Identification of a transferrin-binding protein from Borrelia burgdorferi. Carroll, J.A., Dorward, D.W., Gherardini, F.C. Infect. Immun. (1996) [Pubmed]
  18. Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo. Staniforth, V., Wang, S.Y., Shyur, L.F., Yang, N.S. J. Biol. Chem. (2004) [Pubmed]
  19. Positive regulation of tRNA gene expression by the mouse mammary tumor virus-long terminal repeat in vitro. Ye, S., Kmiec, E.B. Nucleic Acids Res. (1993) [Pubmed]
  20. Intracellular association of the protein product of the c-myc oncogene with the TATA-binding protein. Maheswaran, S., Lee, H., Sonenshein, G.E. Mol. Cell. Biol. (1994) [Pubmed]
  21. Sub-milliMorgan map of the proximal part of mouse Chromosome 17 including the hybrid sterility 1 gene. Gregorová, S., Mnuková-Fajdelová, M., Trachtulec, Z., Capková, J., Loudová, M., Hoglund, M., Hamvas, R., Lehrach, H., Vincek, V., Klein, J., Forejt, J. Mamm. Genome (1996) [Pubmed]
  22. NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes. Kabe, Y., Yamada, J., Uga, H., Yamaguchi, Y., Wada, T., Handa, H. Mol. Cell. Biol. (2005) [Pubmed]
  23. Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation. Mayr, G.A., Reed, M., Wang, P., Wang, Y., Schweds, J.F., Tegtmeyer, P. Cancer Res. (1995) [Pubmed]
  24. The interaction of GATA-binding proteins and basal transcription factors with GATA box-containing core promoters. A model of tissue-specific gene expression. Aird, W.C., Parvin, J.D., Sharp, P.A., Rosenberg, R.D. J. Biol. Chem. (1994) [Pubmed]
  25. Gene structure and sequence analysis of mouse centromere proteins A and C. Kalitsis, P., MacDonald, A.C., Newson, A.J., Hudson, D.F., Choo, K.H. Genomics (1998) [Pubmed]
  26. Genomics and transcription analysis of human TFIID. Purrello, M., Di Pietro, C., Viola, A., Rapisarda, A., Stevens, S., Guermah, M., Tao, Y., Bonaiuto, C., Arcidiacono, A., Messina, A., Sichel, G., Grzeschik, K.H., Roeder, R. Oncogene (1998) [Pubmed]
  27. Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription. Spann, T.P., Goldman, A.E., Wang, C., Huang, S., Goldman, R.D. J. Cell Biol. (2002) [Pubmed]
  28. The alpha chain of the nascent polypeptide-associated complex functions as a transcriptional coactivator. Yotov, W.V., Moreau, A., St-Arnaud, R. Mol. Cell. Biol. (1998) [Pubmed]
 
WikiGenes - Universities