The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

F13A1  -  coagulation factor XIII, A1 polypeptide

Homo sapiens

Synonyms: Coagulation factor XIII A chain, Coagulation factor XIIIa, F13A, Protein-glutamine gamma-glutamyltransferase A chain, Transglutaminase A chain
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of F13A1


High impact information on F13A1

  • A multipoint lod score of 3.9 (P = 2.3 x 10(-5)) was achieved when the F13A1 and D6S260 loci were analysed, allowing for locus heterogeneity [6].
  • However, the disease locus was found to be closely linked to a microsatellite polymorphism, D6S89, which is between HLA and F13A1 [2].
  • The present findings, in combination with earlier knowledge of PGM3/GLO/HLA localization and gene distances, show that F13A is distal to HLA on the short arm of chromosome 6 in man [7].
  • A structural locus for coagulation factor XIIIA (F13A) is located distal to the HLA region on chromosome 6p in man [7].
  • Female data indicate a clear sex difference in recombination frequency between F13A and HLA [7].

Chemical compound and disease context of F13A1


Biological context of F13A1


Anatomical context of F13A1


Associations of F13A1 with chemical compounds


Physical interactions of F13A1


Other interactions of F13A1

  • Four of them showed significant deviations from Hardy-Weinberg expectations in controls, according to the exact test (D4S192, BCL3, F13A1, and D6S89) [25].
  • At the F13A and ORM1 loci, Senegalese have allele frequencies similar to those reported for American blacks [26].
  • Significant epistasis on plasma fibrinogen concentration was detected between the FGA 2224G > A and F13A1 Val34Leu [rs5985] SNPs (p < 0.001) [27].
  • Thus, we have found a new coagulation-factor-XIIIa-sensitive site localized in the cell-binding central fragment, inaccessible to enzyme in the intact fibronectin molecule [24].
  • Allele frequencies and some forensic parameters for 12 autosomal microsatellites (CSF1PO, TPOX, THO1, VWA, D16S539, D7S820, D13S317, D5S818, F13A1, FESFPS, F13B, LPL) were estimated from three departments from Northwestern Colombia [28].

Analytical, diagnostic and therapeutic context of F13A1



  1. The V34L polymorphism of factor XIII and peripheral arterial disease. Renner, W., Brodmann, M., Pabst, E., Stanger, O., Wascher, T.C., Pilger, E. International angiology : a journal of the International Union of Angiology. (2002) [Pubmed]
  2. Tight linkage of the gene for spinocerebellar ataxia to D6S89 on the short arm of chromosome 6 in a kindred for which close linkage to both HLA and F13A1 is excluded. Keats, B.J., Pollack, M.S., McCall, A., Wilensky, M.A., Ward, L.J., Lu, M., Zoghbi, H.Y. Am. J. Hum. Genet. (1991) [Pubmed]
  3. Racial influence on the prevalence of prostate carcinoma in Brazilian volunteers. Paschoalin, E.L., Martins, A.C., Pastorello, M., Sândis, K.A., Maciel, L.M., Silva, W.A., Zago, M.A., Bessa, J. International braz j urol : official journal of the Brazilian Society of Urology. (2003) [Pubmed]
  4. Binding and factor XIIIa-mediated cross-linking of a 27-kilodalton fragment of fibronectin to Staphylococcus aureus. Mosher, D.F., Proctor, R.A. Science (1980) [Pubmed]
  5. Nonsyndromic cleft lip and palate: no evidence of linkage to HLA or factor 13A. Hecht, J.T., Wang, Y., Connor, B., Blanton, S.H., Daiger, S.P. Am. J. Hum. Genet. (1993) [Pubmed]
  6. Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22. Wang, S., Sun, C.E., Walczak, C.A., Ziegle, J.S., Kipps, B.R., Goldin, L.R., Diehl, S.R. Nat. Genet. (1995) [Pubmed]
  7. A structural locus for coagulation factor XIIIA (F13A) is located distal to the HLA region on chromosome 6p in man. Olaisen, B., Gedde-Dahl, T., Teisberg, P., Thorsby, E., Siverts, A., Jonassen, R., Wilhelmy, M.C. Am. J. Hum. Genet. (1985) [Pubmed]
  8. Deficiency of blood coagulation factor XIII in Crohn's disease. Oshitani, N., Kitano, A., Hara, J., Suzuki, N., Aoki, T., Yasuda, K., Watanabe, Y., Obayashi, M., Obata, A., Nakamura, S. Am. J. Gastroenterol. (1995) [Pubmed]
  9. The association between fibrinogen haplotypes and myocardial infarction in men is partly mediated through pleiotropic effects on the serum IL-6 concentration. Mannila, M.N., Eriksson, P., Leander, K., Wiman, B., de Faire, U., Hamsten, A., Silveira, A. J. Intern. Med. (2007) [Pubmed]
  10. The human endothelin-1 gene (EDN1) encoding a peptide with potent vasoactive properties maps distal to HLA on chromosome arm 6p in close linkage to D6S89. Hoehe, M.R., Ehrenreich, H., Otterud, B., Caenazzo, L., Plaetke, R., Zander, H., Leppert, M. Cytogenet. Cell Genet. (1993) [Pubmed]
  11. Familial ureteral abnormalities syndrome: genomic mapping, clinical findings. Klemme, L., Fish, A.J., Rich, S., Greenberg, B., Senske, B., Segall, M. Pediatr. Nephrol. (1998) [Pubmed]
  12. Diversity of two short tandem repeat loci (CD4 and F13A1) in three Brazilian ethnic groups. Bogdawa, H.M., Hutz, M.H., Salzano, F.M., Weimer, T.A. Hum. Biol. (2000) [Pubmed]
  13. Labeling of a major fibroblast surface protein (fibronectin) catalyzed by blood coagulation factor XIIa. Mosher, D.F. Biochim. Biophys. Acta (1977) [Pubmed]
  14. Half-of-the-sites and all-of-the-sites reactivity in human plasma blood coagulation factor XIIIa. Seelig, G.F., Folk, J.E. J. Biol. Chem. (1980) [Pubmed]
  15. Coagulation factor XIII A and B subunits in bone marrow and liver transplantation. Wölpl, A., Lattke, H., Board, P.G., Arnold, R., Schmeiser, T., Kubanek, B., Robin-Winn, M., Pichelmayr, R., Goldmann, S.F. Transplantation (1987) [Pubmed]
  16. Deletion and linkage mapping of eight markers from the proximal short arm of chromosome 6. Zoghbi, H.Y., Ballantyne, C.M., O'Brien, W.E., McCall, A.E., Kwiatkowski, T.J., Ledbetter, S.A., Beaudet, A.L. Genomics (1990) [Pubmed]
  17. Mammary fibroadenoma and some phyllodes tumour stroma are composed of CD34+ fibroblasts and factor XIIIa+ dendrophages. Silverman, J.S., Tamsen, A. Histopathology (1996) [Pubmed]
  18. Evidence that the two amino termini of plasma fibronectin are in close proximity: a fluorescence energy transfer study. Wolff, C., Lai, C.S. Biochemistry (1988) [Pubmed]
  19. Fluorescence energy transfer detects changes in fibronectin structure upon surface binding. Wolff, C., Lai, C.S. Arch. Biochem. Biophys. (1989) [Pubmed]
  20. Coagulation factor XIIIa undergoes a conformational change evoked by glutamine substrate. Studies on kinetics of inhibition and binding of XIIIA by a cross-reacting antifibrinogen antibody. Mitkevich, O.V., Shainoff, J.R., DiBello, P.M., Yee, V.C., Teller, D.C., Smejkal, G.B., Bishop, P.D., Kolotushkina, I.S., Fickenscher, K., Samokhin, G.P. J. Biol. Chem. (1998) [Pubmed]
  21. Alpha-chain domain of fibrinogen controls generation of fibrinoligase (coagulation factor XIIIa). Calcium ion regulatory aspects. Credo, R.B., Curtis, C.G., Lorand, L. Biochemistry (1981) [Pubmed]
  22. Coagulation factor XIII: a useful polymorphic genetic marker. Graham, J.B., Edgell, C.J., Fleming, H., Namboodiri, K.K., Keats, B.J., Elston, R.C. Hum. Genet. (1984) [Pubmed]
  23. Transdab wiki: the interactive transglutaminase substrate database on web 2.0 surface. Csosz, E., Meskó, B., Fésüs, L. Amino. Acids. (2009) [Pubmed]
  24. Transglutaminase-sensitive glutamine residues of human plasma fibronectin revealed by studying its proteolytic fragments. Fesus, L., Metsis, M.L., Muszbek, L., Koteliansky, V.E. Eur. J. Biochem. (1986) [Pubmed]
  25. Association between 10 microsatellite markers and nonsyndromic cleft lip palate in the Chilean population. Blanco, R., Suazo, J., Santos, J.L., Paredes, M., Sung, H., Carreño, H., Jara, L. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. (2004) [Pubmed]
  26. Genetic studies on the Senegal population. II. Polymorphisms of the plasma proteins F13A, F13B, ORM1, AHSG, C6, C7, and APOC2. Corbo, R.M., Scacchi, R., Cossu, G., Brega, A., Scozzari, R. Hum. Biol. (1994) [Pubmed]
  27. Epistatic and pleiotropic effects of polymorphisms in the fibrinogen and coagulation factor XIII genes on plasma fibrinogen concentration, fibrin gel structure and risk of myocardial infarction. Mannila, M.N., Eriksson, P., Ericsson, C.G., Hamsten, A., Silveira, A. Thromb. Haemost. (2006) [Pubmed]
  28. Autosomal microsatellite data from Northwestern Colombia. Palacio, O.D., Triana, O., Gaviria, A., Ibarra, A.A., Ochoa, L.M., Posada, Y., Maya, M.C., Lareu, M.V., Brión, M., Acosta, M.A., Carracedo, A. Forensic Sci. Int. (2006) [Pubmed]
  29. Molecular assessment of post-BMT chimerism using various biologic specimens and automated DNA sizing technology. Jółkowska, J., Wachowiak, J., Lange, A., Kwissa, M., Witt, M. J. Hematother. Stem Cell Res. (2000) [Pubmed]
  30. Molecular basis for subtypic differences of the "a" subunit of coagulation factor XIII with description of the genesis of the subtypes. Suzuki, K., Iwata, M., Ito, S., Matsui, K., Uchida, A., Mizoi, Y. Hum. Genet. (1994) [Pubmed]
  31. Using hydrophilic adhesive tape for collection of evidence for forensic DNA analysis. Li, R.C., Harris, H.A. J. Forensic Sci. (2003) [Pubmed]
  32. Genetic polymorphisms of the A and B subunits of coagulation factor XIII in the Chinese population. Zhang, L., Stradmann-Bellinghausen, B., Schneider, P.M., Rittner, C. Exp. Clin. Immunogenet. (1993) [Pubmed]
  33. Denaturation-renaturation of the fibrin-stabilizing factor XIII a-chain isolated from human placenta. Properties of the native and reconstituted protein. Rinas, U., Risse, B., Jaenicke, R., Abel, K.J., Zettlmeissl, G. Biol. Chem. Hoppe-Seyler (1990) [Pubmed]
WikiGenes - Universities