Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Nmur2 - neuromedin U receptor 2

Mus musculus

Zeng, H., Graham, E.S., Moriyama, M.

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Disease relevance of Nmur2

In contrast to the NMU peptide-deficient mice, NMUR2 KO mice appeared normal with regard to stress, anxiety, body weight regulation, and food consumption [1].

High impact information on Nmur2

Whereas NMU-R2 localizes predominantly to nerve cells, NMU-R1 is expressed in peripheral tissues including lymphocytes and monocytes, suggesting a role of NMU in immunoregulation [2].
Here we report the generation and phenotypic characterization of mice deficient in the central nervous system receptor NMUR2 [1].
However, the NMUR2 KO mice showed reduced pain sensitivity in both the hot plate and formalin tests [1].
We show that behavioral effects, such as suppression of food intake, enhanced pain response, and excessive grooming induced by intracerebroventricular NMU administration were abolished in the NMUR2 knockout (KO) mice, establishing a causal role for NMUR2 in mediating NMU's central effects on these behaviors [1].
Furthermore, facilitated excitatory synaptic transmission in spinal dorsal horn neurons, a mechanism by which NMU stimulates pain, did not occur in NMUR2 KO mice [1].

Biological context of Nmur2

The objective of this study was to identify the sites of gene expression for NMU and the NMU receptor-2 (NMU2R) in the mouse and rat hypothalamus and ascertain the effects of nutritional status on the expression of these genes [3].

Anatomical context of Nmur2

Neuromedin U and Neuromedin U receptor-2 expression in the mouse and rat hypothalamus: effects of nutritional status [3].

References

Neuromedin u receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding. Zeng, H., Gragerov, A., Hohmann, J.G., Pavlova, M.N., Schimpf, B.A., Xu, H., Wu, L.J., Toyoda, H., Zhao, M.G., Rohde, A.D., Gragerova, G., Onrust, R., Bergmann, J.E., Zhuo, M., Gaitanaris, G.A. Mol. Cell. Biol. (2006)
The neuropeptide neuromedin U promotes inflammation by direct activation of mast cells. Moriyama, M., Sato, T., Inoue, H., Fukuyama, S., Teranishi, H., Kangawa, K., Kano, T., Yoshimura, A., Kojima, M. J. Exp. Med. (2005)
Neuromedin U and Neuromedin U receptor-2 expression in the mouse and rat hypothalamus: effects of nutritional status. Graham, E.S., Turnbull, Y., Fotheringham, P., Nilaweera, K., Mercer, J.G., Morgan, P.J., Barrett, P. J. Neurochem. (2003)