Gene Review:
FANCD2 - Fanconi anemia, complementation group D2
Homo sapiens
Synonyms:
FA-D2, FA4, FACD, FAD, FAD2, ...
Pichierri,
Franchitto,
Rosselli,
Howlett,
Taniguchi,
Durkin,
D'Andrea,
Glover,
Grompe,
D'Andrea,
Rothfuss,
Grompe,
Soulier,
Leblanc,
Larghero,
Dastot,
Shimamura,
Guardiola,
Esperou,
Ferry,
Jubert,
Feugeas,
Henri,
Toubert,
Socié,
Baruchel,
Sigaux,
D'Andrea,
Gluckman,
Shimamura,
de Oca,
Svenson,
Haining,
Moreau,
Nathan,
D'Andrea,
- The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia. Levran, O., Attwooll, C., Henry, R.T., Milton, K.L., Neveling, K., Rio, P., Batish, S.D., Kalb, R., Velleuer, E., Barral, S., Ott, J., Petrini, J., Schindler, D., Hanenberg, H., Auerbach, A.D. Nat. Genet. (2005)
- Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Garcia-Higuera, I., Taniguchi, T., Ganesan, S., Meyn, M.S., Timmers, C., Hejna, J., Grompe, M., D'Andrea, A.D. Mol. Cell (2001)
- The Fanconi anaemia genome stability and tumour suppressor network. Bogliolo, M., Cabré, O., Callén, E., Castillo, V., Creus, A., Marcos, R., Surrallés, J. Mutagenesis (2002)
- Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Taniguchi, T., Garcia-Higuera, I., Xu, B., Andreassen, P.R., Gregory, R.C., Kim, S.T., Lane, W.S., Kastan, M.B., D'Andrea, A.D. Cell (2002)
- Interaction of FANCD2 and NBS1 in the DNA damage response. Nakanishi, K., Taniguchi, T., Ranganathan, V., New, H.V., Moreau, L.A., Stotsky, M., Mathew, C.G., Kastan, M.B., Weaver, D.T., D'Andrea, A.D. Nat. Cell Biol. (2002)
- Inherited neurodegenerative diseases and transgenic models. Price, D.L., Becher, M.W., Wong, P.C., Borchelt, D.R., Lee, M.K., Sisodia, S.S. Brain Pathol. (1996)
- A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Meetei, A.R., Medhurst, A.L., Ling, C., Xue, Y., Singh, T.R., Bier, P., Steltenpool, J., Stone, S., Dokal, I., Mathew, C.G., Hoatlin, M., Joenje, H., de Winter, J.P., Wang, W. Nat. Genet. (2005)
- X-linked inheritance of Fanconi anemia complementation group B. Meetei, A.R., Levitus, M., Xue, Y., Medhurst, A.L., Zwaan, M., Ling, C., Rooimans, M.A., Bier, P., Hoatlin, M., Pals, G., de Winter, J.P., Wang, W., Joenje, H. Nat. Genet. (2004)
- A novel ubiquitin ligase is deficient in Fanconi anemia. Meetei, A.R., de Winter, J.P., Medhurst, A.L., Wallisch, M., Waisfisz, Q., van de Vrugt, H.J., Oostra, A.B., Yan, Z., Ling, C., Bishop, C.E., Hoatlin, M.E., Joenje, H., Wang, W. Nat. Genet. (2003)
- Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway. Chirnomas, D., Taniguchi, T., de la Vega, M., Vaidya, A.P., Vasserman, M., Hartman, A.R., Kennedy, R., Foster, R., Mahoney, J., Seiden, M.V., D'Andrea, A.D. Mol. Cancer Ther. (2006)
- Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Nakanishi, K., Yang, Y.G., Pierce, A.J., Taniguchi, T., Digweed, M., D'Andrea, A.D., Wang, Z.Q., Jasin, M. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways. Hussain, S., Wilson, J.B., Medhurst, A.L., Hejna, J., Witt, E., Ananth, S., Davies, A., Masson, J.Y., Moses, R., West, S.C., de Winter, J.P., Ashworth, A., Jones, N.J., Mathew, C.G. Hum. Mol. Genet. (2004)
- The Chinese hamster FANCG/XRCC9 mutant NM3 fails to express the monoubiquitinated form of the FANCD2 protein, is hypersensitive to a range of DNA damaging agents and exhibits a normal level of spontaneous sister chromatid exchange. Wilson, J.B., Johnson, M.A., Stuckert, A.P., Trueman, K.L., May, S., Bryant, P.E., Meyn, R.E., D'Andrea, A.D., Jones, N.J. Carcinogenesis (2001)
- The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability. Howlett, N.G., Taniguchi, T., Durkin, S.G., D'Andrea, A.D., Glover, T.W. Hum. Mol. Genet. (2005)
- Detection of somatic mosaicism and classification of Fanconi anemia patients by analysis of the FA/BRCA pathway. Soulier, J., Leblanc, T., Larghero, J., Dastot, H., Shimamura, A., Guardiola, P., Esperou, H., Ferry, C., Jubert, C., Feugeas, J.P., Henri, A., Toubert, A., Socié, G., Baruchel, A., Sigaux, F., D'Andrea, A.D., Gluckman, E. Blood (2005)
- BRCA1-independent ubiquitination of FANCD2. Vandenberg, C.J., Gergely, F., Ong, C.Y., Pace, P., Mallery, D.L., Hiom, K., Patel, K.J. Mol. Cell (2003)
- Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin. Montes de Oca, R., Andreassen, P.R., Margossian, S.P., Gregory, R.C., Taniguchi, T., Wang, X., Houghtaling, S., Grompe, M., D'Andrea, A.D. Blood (2005)
- A novel diagnostic screen for defects in the Fanconi anemia pathway. Shimamura, A., de Oca, R.M., Svenson, J.L., Haining, N., Moreau, L.A., Nathan, D.G., D'Andrea, A.D. Blood (2002)
- Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors. Taniguchi, T., Tischkowitz, M., Ameziane, N., Hodgson, S.V., Mathew, C.G., Joenje, H., Mok, S.C., D'Andrea, A.D. Nat. Med. (2003)
- Nbs1 is required for ATR-dependent phosphorylation events. Stiff, T., Reis, C., Alderton, G.K., Woodbine, L., O'Driscoll, M., Jeggo, P.A. EMBO J. (2005)
- Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway. Rothfuss, A., Grompe, M. Mol. Cell. Biol. (2004)
- The WD40 Repeats of FANCL Are Required for Fanconi Anemia Core Complex Assembly. Gurtan, A.M., Stuckert, P., D'Andrea, A.D. J. Biol. Chem. (2006)
- Phenotype of chromosome 14-linked familial Alzheimer's disease in a large kindred. Lampe, T.H., Bird, T.D., Nochlin, D., Nemens, E., Risse, S.C., Sumi, S.M., Koerker, R., Leaird, B., Wier, M., Raskind, M.A. Ann. Neurol. (1994)
- ATR couples FANCD2 monoubiquitination to the DNA-damage response. Andreassen, P.R., D'Andrea, A.D., Taniguchi, T. Genes Dev. (2004)
- Menin associates with FANCD2, a protein involved in repair of DNA damage. Jin, S., Mao, H., Schnepp, R.W., Sykes, S.M., Silva, A.C., D'Andrea, A.D., Hua, X. Cancer Res. (2003)
- The nuclear accumulation of the Fanconi anemia protein FANCE depends on FANCC. Léveillé, F., Ferrer, M., Medhurst, A.L., Laghmani, e.l. .H., Rooimans, M.A., Bier, P., Steltenpool, J., Titus, T.A., Postlethwait, J.H., Hoatlin, M.E., Joenje, H., de Winter, J.P. DNA Repair (Amst.) (2006)
- Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance. Ho, G.P., Margossian, S., Taniguchi, T., D'Andrea, A.D. Mol. Cell. Biol. (2006)
- Fanconi anemia and DNA repair. Grompe, M., D'Andrea, A. Hum. Mol. Genet. (2001)
- FANCD2 protein is expressed in proliferating cells of human tissues that are cancer-prone in Fanconi anaemia. Hölzel, M., van Diest, P.J., Bier, P., Wallisch, M., Hoatlin, M.E., Joenje, H., de Winter, J.P. J. Pathol. (2003)
- FANCE: the link between Fanconi anaemia complex assembly and activity. Pace, P., Johnson, M., Tan, W.M., Mosedale, G., Sng, C., Hoatlin, M., de Winter, J., Joenje, H., Gergely, F., Patel, K.J. EMBO J. (2002)
- BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks. Pichierri, P., Franchitto, A., Rosselli, F. EMBO J. (2004)
- The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. Nijman, S.M., Huang, T.T., Dirac, A.M., Brummelkamp, T.R., Kerkhoven, R.M., D'Andrea, A.D., Bernards, R. Mol. Cell (2005)
- Variation in cisplatinum sensitivity is not associated with Fanconi Anemia/BRCA pathway inactivation in head and neck squamous cell carcinoma cell lines. Snyder, E.R., Ricker, J.L., Chen, Z., Waes, C.V. Cancer Lett. (2007)
- FANCD2 expression in advanced non-small-cell lung cancer and response to platinum-based chemotherapy. Ferrer, M., Span, S.W., Vischioni, B., Oudejans, J.J., van Diest, P.J., de Winter, J.P., Giaccone, G., Kruyt, F.A. Clinical lung cancer. (2005)
- Molecular cloning of the Drosophila Fanconi anaemia gene FANCD2 cDNA. Castillo, V., Cabré, O., Marcos, R., Surrallés, J. DNA Repair (Amst.) (2003)
- Cloning and Sequence Analysis of Maize FAD2 Gene. Tao, F., Zhu, S.W., Fan, J., Cheng, B.J. Zhi Wu Sheng Li Yu Fen Zi Sheng Wu Xue Xue Bao (2006)