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Gene Review

Thy1  -  thymus cell antigen 1, theta

Mus musculus

Synonyms: CD90, T25, Thy 1.2, Thy-1, Thy-1 antigen, ...
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Disease relevance of Thy1

  • Anti-Thy1 nephritis was induced in Wistar rats by injecting mouse anti-rat Thy1 antibodies intravenously [1].
  • RESULTS: RGCs comprise 67.5% +/- 6.5% (mean +/- SD) of cells in the ganglion cell layer (GCL) of control mice based on nuclear morphology and the presence of mRNA for the ganglion cell marker Thy1 [2].
  • Expression of Thy1, TL and LYT antigens on spontaneous leukemias of BALB/MO strain of mice [3].
  • After subcloning into a plasmid vector containing the bacterial Eco-gpt gene as a selectable marker, the Thy-1 gene was introduced into the Thy-1-deficient mouse lymphoma AKR1 (Thy-1-d), and the rat neuronal cell line, B50 [4].
  • The Thy-1.2, Lyt-2, and T-30 differentiation antigens were not detected on any B lymphoma or plasmacytoma [5].

Psychiatry related information on Thy1

  • Independent and cooperative behavior of Thy1 and CD3:TcR T cell signalling pathways [6].
  • RESULTS: We show here that Thy-1 null mice are unable to make the appropriate dietary choice in the test for social transmission of food preference, despite showing a normal level of social interaction with the demonstrator mouse, normal neophobia, and normal learning in a T-maze using scented food as cues [7].
  • Analogous to a successful strategy for the production of transgenic animal models for Alzheimer's disease we generated mice expressing wildtype and the A53T mutant of human alphaSN in the nervous system under control of mouse Thy1 regulatory sequences [8].
  • Rabbit antisera specific for idiotypic determinants (Id) of monoclonal Thy-1 autoantibodies were tested for their capacity to elicit Id-bearing thymus autoantibodies in mice [9].

High impact information on Thy1


Chemical compound and disease context of Thy1


Biological context of Thy1

  • These antigens include histocompatibility antigens of the H-2 complex (H-2.8 of the K-end and H-2dx(D) of the H-2dx haplotype) and two thymic markers, TL1.2 and Thy1 [19].
  • The genes for two other cell surface molecules believed to be involved in cell-cell interactions, Thy-1 and the delta chain of the T3-T cell receptor complex, have recently been localized to the same region of chromosome 11 in man [20].
  • The complete exon/intron structure and the nucleotide sequence of the Thy-1.2 gene was determined [21].
  • The entire coding sequence of Thy-1 is distributed among three exons, encoding amino acid residues -19 to 8, -7 to 106, and 107 to 143, respectively [22].
  • These L-cell lines contain between two and four copies of the cloned Thy-1 gene stably integrated in the host genome [4].

Anatomical context of Thy1

  • (a) NK cells do not express Thy1, Ly2, or Ig surface markers [23].
  • In addition, while thymic expression of Thy1 is relatively normal, peripheral T cells isolated from Ets-1 mutant mice display a striking loss of Thy1 expression [24].
  • Additionally, Thy1 was found to be induced only on those B cell subsets capable of producing IgE [25].
  • The combination of saponin and digitonin treatment was also compatible with the staining of sCD3 and other lymphocyte surface antigens such as Thy1, CD4, CD8, B220, and IgM [26].
  • 1. In addition, some rapidly renewed bone marrow lymphocytes express low intensities of Thy1 (Thy1lo) [27].

Associations of Thy1 with chemical compounds

  • Further studies tested for LPS and IL-4-induced expression of Fc epsilon RII and Thy1 on the various B cell populations [25].
  • In each case, the number of null lymphocytes, as defined by a lack of radioautographic labeling of either B220 glycoprotein or Thy1, increased markedly in both the bone marrow and spleen [27].
  • Moreover, sulfate glycans could modulate the binding of rat mAb directed at spatially distinct Thy-1 epitopes [28].
  • It was shown that 125I-labeled Thy-1 directly bound to immobilized heparin [28].
  • By cross-hybridization with a mouse Thy-1 probe, we isolated cDNA clones from a pcD-expression library prepared from mRNA of C5 cells [29].

Physical interactions of Thy1

  • Resting murine T cell activation induced by either CD3 complexes or Thy1 molecules was investigated in vitro, using surface-bound anti-CD3 mAb as the stimulus [30].
  • Although both of these pathways are initiated by an increased activity of Lyn kinase, the exact mechanism by which Lyn kinase interacts with aggregated FcepsilonRI and Thy-1 is not completely understood [31].
  • Differential expression of class II major histocompatibility complex and Thy 1.2 antigens on mouse decidua [32].

Regulatory relationships of Thy1

  • The brain T cell cross-reactive, mitogenic determinant is not expressed on Thy-1- mutants of the BW5147 T cell lymphoma that fail to express the Thy-1 molecule but do express other T cell surface proteins such as T-200 and gp 69, 71 [33].
  • The majority of cells demonstrating TGF-beta activation and myofibroblast differentiation in bleomycin-induced lesions were Thy-1-negative [34].
  • Since the Thy1 triggering pathway has different accessory cell and cytokine requirements than does the CD3: TCR lymphocyte activation pathway, it is possible that immunization was more effective in changing the cellular interactions of the T-lymphocyte than in altering its intrinsic capabilities [35].
  • However, the Thy1 pathway is also regulated independently since IL2 production is larger when stimulated by anti-Thy1 than anti-CD3 mAbs [6].
  • First, a profound inhibition of primary PFC responses occurs when foreign H-2 antigens are expressed on Thy-1 incompatible donor cells [36].

Other interactions of Thy1


Analytical, diagnostic and therapeutic context of Thy1


  1. Honokiol, a small molecular weight natural product, alleviates experimental mesangial proliferative glomerulonephritis. Chiang, C.K., Sheu, M.L., Hung, K.Y., Wu, K.D., Liu, S.H. Kidney Int. (2006) [Pubmed]
  2. Experimental induction of retinal ganglion cell death in adult mice. Li, Y., Schlamp, C.L., Nickells, R.W. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  3. Expression of Thy1, TL and LYT antigens on spontaneous leukemias of BALB/MO strain of mice. Strzadała, L., Opolski, A., Kisielow, P. Arch. Immunol. Ther. Exp. (Warsz.) (1981) [Pubmed]
  4. Expression of the Thy-1 glycoprotein gene by DNA-mediated gene transfer. Evans, G.A., Ingraham, H.A., Lewis, K., Cunningham, K., Seki, T., Moriuchi, T., Chang, H.C., Silver, J., Hyman, R. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  5. Quantitative immunofluorescent analysis of surface phenotypes of murine B cell lymphomas and plasmacytomas with monoclonal antibodies. Lanier, L.L., Warner, N.L., Ledbetter, J.A., Herzenberg, L.A. J. Immunol. (1981) [Pubmed]
  6. Independent and cooperative behavior of Thy1 and CD3:TcR T cell signalling pathways. Leal, L.M., Dosreis, G.A. Braz. J. Med. Biol. Res. (1990) [Pubmed]
  7. Mice lacking the cell adhesion molecule Thy-1 fail to use socially transmitted cues to direct their choice of food. Mayeux-Portas, V., File, S.E., Stewart, C.L., Morris, R.J. Curr. Biol. (2000) [Pubmed]
  8. Mouse models of alpha-synucleinopathy and Lewy pathology. Sommer, B., Barbieri, S., Hofele, K., Wiederhold, K., Probst, A., Mistl, C., Danner, S., Kauffmann, S., Spooren, W., Tolnay, M., Bilbe, G., van der Putten H, n.u.l.l., Kafmann, S., Caromi, P., Ruegg, M.A. Exp. Gerontol. (2000) [Pubmed]
  9. Idiotype regulation of thymus autoantibodies. Rabinowitz, R., Hadar, R., Schlesinger, M. Immunology (1988) [Pubmed]
  10. A lymphoproliferative abnormality associated with inappropriate expression of the Thy-1 antigen in transgenic mice. Chen, S., Botteri, F., van der Putten, H., Landel, C.P., Evans, G.A. Cell (1987) [Pubmed]
  11. Regulation of Thy-1 gene expression in transgenic mice. Gordon, J.W., Chesa, P.G., Nishimura, H., Rettig, W.J., Maccari, J.E., Endo, T., Seravalli, E., Seki, T., Silver, J. Cell (1987) [Pubmed]
  12. Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities. Kollias, G., Evans, D.J., Ritter, M., Beech, J., Morris, R., Grosveld, F. Cell (1987) [Pubmed]
  13. Abnormal lipid-linked oligosaccharides in class E Thy-1-negative mutant lymphomas. Trowbridge, I.S., Hyman, R. Cell (1979) [Pubmed]
  14. The mouse Thy-1.2 glycoprotein gene: complete sequence and identification of an unusual promoter. Ingraham, H.A., Lawless, G.M., Evans, G.A. J. Immunol. (1986) [Pubmed]
  15. In vivo activation of langerhans cells and dendritic epidermal T cells in the elicitation phase of murine contact hypersensitivity. Tsuruta, D., Kaneda, K., Teramae, H., Ishii, M. Br. J. Dermatol. (1999) [Pubmed]
  16. Indomethacin-induced sialic acid-mediated changes in surface markers from "cortical type" to "medullary type" in murine thymoma line EL-4. Tomooka, S., Serushago, B.A., Koga, Y., Taniguchi, K., Nomoto, K. Immunobiology (1986) [Pubmed]
  17. Thy-1 variants of mouse lymphomas: biochemical characterization of the genetic defect. Trowbridge, I.S., Hyman, R. Cell (1975) [Pubmed]
  18. Atypical mannolipids characterize Thy-1-negative lymphoma mutants. Lemansky, P., Gupta, D.K., Meyale, S., Tucker, G., Tartakoff, A.M. Mol. Cell. Biol. (1991) [Pubmed]
  19. Antigenic modulation of mammary tumour virus envelope antigen or GR thymic lymphoma cells in relation to expressions of H-2, TL cell-surface antigens and THY1. Hilgers, J., Sonnenberg, A., Nusse, R. Br. J. Cancer (1980) [Pubmed]
  20. Localization of the human NCAM gene to band q23 of chromosome 11: the third gene coding for a cell interaction molecule mapped to the distal portion of the long arm of chromosome 11. Nguyen, C., Mattei, M.G., Mattei, J.F., Santoni, M.J., Goridis, C., Jordan, B.R. J. Cell Biol. (1986) [Pubmed]
  21. Structure of the murine Thy-1 gene. Giguére, V., Isobe, K., Grosveld, F. EMBO J. (1985) [Pubmed]
  22. Isolation and characterization of mouse Thy-1 genomic clones. Chang, H.C., Seki, T., Moriuchi, T., Silver, J. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  23. Identification of a cell-surface antigen selectively expressed on the natural killer cell. Glimcher, L., Shen, F.W., Cantor, H. J. Exp. Med. (1977) [Pubmed]
  24. Impaired generation of CD8+ thymocytes in Ets-1-deficient mice. Clements, J.L., John, S.A., Garrett-Sinha, L.A. J. Immunol. (2006) [Pubmed]
  25. Switching capacity of Fc epsilon RII-positive and -negative murine B cells. Foy, T.M., Waldschmidt, T.J. Eur. J. Immunol. (1993) [Pubmed]
  26. Reliable method for the simultaneous detection of cytoplasmic and surface CD3 epsilon expression by murine lymphoid cells. Franek, K.J., Wolcott, R.M., Chervenak, R. Cytometry. (1994) [Pubmed]
  27. Changes in the populations of null, NK1.1+, and Thy1lo lymphocytes in the bone marrow of tumor-bearing mice: effect of indomethacin treatment. Rahal, M.D., Reinish, E., Osmond, D.G. Cell. Immunol. (1992) [Pubmed]
  28. Sulfated glycans directly interact with mouse Thy-1 and negatively regulate Thy-1-mediated adhesion of thymocytes to thymic epithelial cells. Hueber, A.O., Pierres, M., He, H.T. J. Immunol. (1992) [Pubmed]
  29. Isolation and characterization of expressible cDNA clones for mouse Thy-1: a model system for cDNA expression of cell surface proteins. Hiraki, D.D., Nomura, D., Yokota, T., Arai, K., Coffman, R.L. J. Immunol. (1986) [Pubmed]
  30. Interactions between CD3 and Thy1 T cell activation pathways: blockade of CD3-mediated T lymphocyte activation induced by immobilized anti-Thy1 antibodies. Bellio, M., Leal, L.M., Scharfstein, J., Dos Reis, G.A. Cell. Immunol. (1991) [Pubmed]
  31. Differential sensitivity to acute cholesterol lowering of activation mediated via the high-affinity IgE receptor and Thy-1 glycoprotein. Surviladze, Z., Dráberová, L., Kovárová, M., Boubelík, M., Dráber, P. Eur. J. Immunol. (2001) [Pubmed]
  32. Differential expression of class II major histocompatibility complex and Thy 1.2 antigens on mouse decidua. Searle, R.F., Matthews, C.J. Placenta (1988) [Pubmed]
  33. Evidence that the Thy-1 molecule is the target for T cell mitogenic antibody against brain-associated antigens. Jones, B. Eur. J. Immunol. (1983) [Pubmed]
  34. Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis. Hagood, J.S., Prabhakaran, P., Kumbla, P., Salazar, L., MacEwen, M.W., Barker, T.H., Ortiz, L.A., Schoeb, T., Siegal, G.P., Alexander, C.B., Pardo, A., Selman, M. Am. J. Pathol. (2005) [Pubmed]
  35. T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice. Pompeu, M., Freitas, A.L., dosReis, G.A., Barral-Netto, M. Parasitol. Res. (1992) [Pubmed]
  36. Modulation of Thy-1 alloantibody responses: donor cell-associated H-2 inhibition and augmentation without recipient Ir gene control. Clark, E.A., Lake, P., Favila-Castillo, L. J. Immunol. (1981) [Pubmed]
  37. Characterization of lymphoid tumors induced by a recombinant murine retrovirus carrying the avian v-myc oncogene. Identification of novel (B-lymphoid) tumors in the thymus. Brightman, B.K., Chandy, K.G., Spencer, R.H., Gupta, S., Pattengale, P.K., Fan, H. J. Immunol. (1988) [Pubmed]
  38. Identification of two murine loci homologous to the v-cbl oncogene. Regnier, D.C., Kozak, C.A., Kingsley, D.M., Jenkins, N.A., Copeland, N.G., Langdon, W.Y., Morse, H.C. J. Virol. (1989) [Pubmed]
  39. The F3 neuronal glycosylphosphatidylinositol-linked molecule is localized to glycolipid-enriched membrane subdomains and interacts with L1 and fyn kinase in cerebellum. Olive, S., Dubois, C., Schachner, M., Rougon, G. J. Neurochem. (1995) [Pubmed]
  40. Migration of Thy-1+ dendritic epidermal cells (Thy-1+DEC): Ly48 and TNF-alpha are responsible for the migration of Thy-1+DEC to the epidermis. Tamaki, K., Saitoh, A., Gaspari, A.A., Yasaka, N., Furue, M. J. Invest. Dermatol. (1994) [Pubmed]
  41. Stage-specific expression of mouse BST-1/BP-3 on the early B and T cell progenitors prior to gene rearrangement of antigen receptor. Ishihara, K., Kobune, Y., Okuyama, Y., Itoh, M., Lee, B.O., Muraoka, O., Hirano, T. Int. Immunol. (1996) [Pubmed]
  42. Expression of the neuronal surface glycoprotein Thy-1 is under post-transcriptional control, and is spatially regulated, in the developing olfactory system. Xue, G.P., Calvert, R.A., Morris, R.J. Development (1990) [Pubmed]
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