Gene Review:
Timp3 - tissue inhibitor of metalloproteinase 3
Mus musculus
Synonyms:
Metalloproteinase inhibitor 3, Sun, TIMP-3, Timp-3, Tissue inhibitor of metalloproteinases 3
Lauro,
Khokha,
Smookler,
Hribal,
Hosoya,
Mauriello,
Yoshiba,
Sesti,
Lesot,
Sunnarborg,
Veldhuizen,
McCaig,
Pape,
Cunsolo,
Lee,
Ruch,
Sun,
Kanno,
Sbraccia,
Moyer,
Martin,
Rizza,
Federici,
Sahlberg,
Starcher,
Marchetti,
Thesleff,
Tryggvason,
Moyer,
Stoetzel,
Lewis,
Pape,
Leco,
Porzio,
Serino,
Perrin-Schmitt,
Yoshiba,
Lauro,
Ozawa,
Martin,
Cam,
Reponen,
Leco,
Menghini,
Accili,
Veldhuizen,
- Enforced expression of tissue inhibitor of matrix metalloproteinase-3 affects functional capillary morphogenesis and inhibits tumor growth in a murine tumor model. Spurbeck, W.W., Ng, C.Y., Strom, T.S., Vanin, E.F., Davidoff, A.M. Blood (2002)
- Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation. Chavey, C., Mari, B., Monthouel, M.N., Bonnafous, S., Anglard, P., Van Obberghen, E., Tartare-Deckert, S. J. Biol. Chem. (2003)
- Lack of tissue inhibitor of metalloproteinases-3 results in an enhanced inflammatory response in antigen-induced arthritis. Mahmoodi, M., Sahebjam, S., Smookler, D., Khokha, R., Mort, J.S. Am. J. Pathol. (2005)
- Negative impact of tissue inhibitor of metalloproteinase-3 null mutation on lung structure and function in response to sepsis. Martin, E.L., Moyer, B.Z., Pape, M.C., Starcher, B., Leco, K.J., Veldhuizen, R.A. Am. J. Physiol. Lung Cell Mol. Physiol. (2003)
- Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice. Kassiri, Z., Oudit, G.Y., Sanchez, O., Dawood, F., Mohammed, F.F., Nuttall, R.K., Edwards, D.R., Liu, P.P., Backx, P.H., Khokha, R. Circ. Res. (2005)
- TIMP3 checks inflammation. Black, R.A. Nat. Genet. (2004)
- Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha. Federici, M., Hribal, M.L., Menghini, R., Kanno, H., Marchetti, V., Porzio, O., Sunnarborg, S.W., Rizza, S., Serino, M., Cunsolo, V., Lauro, D., Mauriello, A., Smookler, D.S., Sbraccia, P., Sesti, G., Lee, D.C., Khokha, R., Accili, D., Lauro, R. J. Clin. Invest. (2005)
- A1 antagonism in asthma: better than coffee? Tilley, S.L., Boucher, R.C. J. Clin. Invest. (2005)
- Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3). Leco, K.J., Waterhouse, P., Sanchez, O.H., Gowing, K.L., Poole, A.R., Wakeham, A., Mak, T.W., Khokha, R. J. Clin. Invest. (2001)
- Accelerated apoptosis in the Timp-3-deficient mammary gland. Fata, J.E., Leco, K.J., Voura, E.B., Yu, H.Y., Waterhouse, P., Murphy, G., Moorehead, R.A., Khokha, R. J. Clin. Invest. (2001)
- Differential response of TIMP-3 null mice to the lung insults of sepsis, mechanical ventilation, and hyperoxia. Martin, E.L., McCaig, L.A., Moyer, B.Z., Pape, M.C., Leco, K.J., Lewis, J.F., Veldhuizen, R.A. Am. J. Physiol. Lung Cell Mol. Physiol. (2005)
- Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation. Smookler, D.S., Mohammed, F.F., Kassiri, Z., Duncan, G.S., Mak, T.W., Khokha, R. J. Immunol. (2006)
- Cell and agonist-specific regulation of genes for matrix metalloproteinases and their tissue inhibitors by primary glial cells. Crocker, S.J., Milner, R., Pham-Mitchell, N., Campbell, I.L. J. Neurochem. (2006)
- Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP-3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10. Apte, S.S., Hayashi, K., Seldin, M.F., Mattei, M.G., Hayashi, M., Olsen, B.R. Dev. Dyn. (1994)
- Differential regulation of TIMP-1, -2, and -3 mRNA and protein expressions during mouse incisor development. Yoshiba, N., Yoshiba, K., Stoetzel, C., Perrin-Schmitt, F., Cam, Y., Ruch, J.V., Hosoya, A., Ozawa, H., Lesot, H. Cell Tissue Res. (2006)
- Temporal and spatial expression of tissue inhibitors of metalloproteinases during the natural ovulatory cycle of the mouse. Inderdeo, D.S., Edwards, D.R., Han, V.K., Khokha, R. Biol. Reprod. (1996)
- Increased collagen and aggrecan degradation with age in the joints of Timp3(-/-) mice. Sahebjam, S., Khokha, R., Mort, J.S. Arthritis Rheum. (2007)
- Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues. Leco, K.J., Khokha, R., Pavloff, N., Hawkes, S.P., Edwards, D.R. J. Biol. Chem. (1994)
- Induction of glutathione synthetase by 1,10-phenanthroline. Sun, Y. FEBS Lett. (1997)
- Specific methylation events contribute to the transcriptional repression of the mouse tissue inhibitor of metalloproteinases-3 gene in neoplastic cells. Pennie, W.D., Hegamyer, G.A., Young, M.R., Colburn, N.H. Cell Growth Differ. (1999)
- Metalloproteinase axes increase beta-catenin signaling in primary mouse mammary epithelial cells lacking TIMP3. Hojilla, C.V., Kim, I., Kassiri, Z., Fata, J.E., Fang, H., Khokha, R. J. Cell. Sci. (2007)
- Tissue inhibitor of metalloproteinases-3 is the major metalloproteinase inhibitor in the decidualizing murine uterus. Leco, K.J., Edwards, D.R., Schultz, G.A. Mol. Reprod. Dev. (1996)
- Subtilisin proprotein convertase-6 expression in the mouse uterus during implantation and artificially induced decidualization. Wong, B.S., Liu, S., Schultz, G.A., Rancourt, D.E. Mol. Reprod. Dev. (2002)
- Differential expression of matrix metalloproteinases and their inhibitors in human and mouse lung development. Ryu, J., Vicencio, A.G., Yeager, M.E., Kashgarian, M., Haddad, G.G., Eickelberg, O. Thromb. Haemost. (2005)
- Timp-1, -2 and -3 show coexpression with gelatinases A and B during mouse tooth morphogenesis. Sahlberg, C., Reponen, P., Tryggvason, K., Thesleff, I. Eur. J. Oral Sci. (1999)
- Regulation of hepatic fibrosis and extracellular matrix genes by the th response: new insight into the role of tissue inhibitors of matrix metalloproteinases. Vaillant, B., Chiaramonte, M.G., Cheever, A.W., Soloway, P.D., Wynn, T.A. J. Immunol. (2001)
- The balance between proteinases and inhibitors in a murine model of proliferative retinopathy. Majka, S., McGuire, P., Colombo, S., Das, A. Invest. Ophthalmol. Vis. Sci. (2001)
- Heart extracellular matrix gene expression profile in the vitamin D receptor knockout mice. Rahman, A., Hershey, S., Ahmed, S., Nibbelink, K., Simpson, R.U. J. Steroid Biochem. Mol. Biol. (2007)
- Molecular cloning of mouse tissue inhibitor of metalloproteinases-3 and its promoter. Specific lack of expression in neoplastic JB6 cells may reflect altered gene methylation. Sun, Y., Hegamyer, G., Kim, H., Sithanandam, K., Li, H., Watts, R., Colburn, N.H. J. Biol. Chem. (1995)