Gene Review:
FANCG - Fanconi anemia, complementation group G
Homo sapiens
Synonyms:
DNA repair protein XRCC9, FAG, Fanconi anemia group G protein, Protein FACG, XRCC9
Meyer,
Barber,
White,
Will,
Birch,
Kohler,
Ersfeld,
Blom,
Joenje,
Eden,
Malcolm Taylor,
Hinz,
Nham,
Yamada,
Tebbs,
Salazar,
Hinz,
Mohrenweiser,
Jones,
Thompson,
Huber,
Medhurst,
Youssoufian,
Mathew,
Tamary,
Dgany,
Toledano,
Shalev,
Krasnov,
Shalmon,
Schechter,
Bercovich,
Attias,
Laor,
Koren,
Yaniv,
Couch,
Johnson,
Rabe,
Boardman,
McWilliams,
de Andrade,
Petersen,
Gordon,
Buchwald,
- Carboxy terminal region of the Fanconi anemia protein, FANCG/XRCC9, is required for functional activity. Kuang, Y., Garcia-Higuera, I., Moran, A., Mondoux, M., Digweed, M., D'Andrea, A.D. Blood (2000)
- Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia. Lensch, M.W., Tischkowitz, M., Christianson, T.A., Reifsteck, C.A., Speckhart, S.A., Jakobs, P.M., O'Dwyer, M.E., Olson, S.B., Le Beau, M.M., Hodgson, S.V., Mathew, C.G., Larson, R.A., Bagby, G.C. Blood (2003)
- The genetics of FANCC and FANCG in familial pancreatic cancer. Rogers, C.D., van der Heijden, M.S., Brune, K., Yeo, C.J., Hruban, R.H., Kern, S.E., Goggins, M. Cancer Biol. Ther. (2004)
- Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options. Gallmeier, E., Calhoun, E.S., Rago, C., Brody, J.R., Cunningham, S.C., Hucl, T., Gorospe, M., Kohli, M., Lengauer, C., Kern, S.E. Gastroenterology (2006)
- The Fanconi anaemia group G gene FANCG is identical with XRCC9. de Winter, J.P., Waisfisz, Q., Rooimans, M.A., van Berkel, C.G., Bosnoyan-Collins, L., Alon, N., Carreau, M., Bender, O., Demuth, I., Schindler, D., Pronk, J.C., Arwert, F., Hoehn, H., Digweed, M., Buchwald, M., Joenje, H. Nat. Genet. (1998)
- Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia. Mukhopadhyay, S.S., Leung, K.S., Hicks, M.J., Hastings, P.J., Youssoufian, H., Plon, S.E. J. Cell Biol. (2006)
- A physical complex of the Fanconi anemia proteins FANCG/XRCC9 and FANCA. Waisfisz, Q., de Winter, J.P., Kruyt, F.A., de Groot, J., van der Weel, L., Dijkmans, L.M., Zhi, Y., Arwert, F., Scheper, R.J., Youssoufian, H., Hoatlin, M.E., Joenje, H. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Phosphorylation of fanconi anemia (FA) complementation group G protein, FANCG, at serine 7 is important for function of the FA pathway. Qiao, F., Mi, J., Wilson, J.B., Zhi, G., Bucheimer, N.R., Jones, N.J., Kupfer, G.M. J. Biol. Chem. (2004)
- The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells. Liu, N., Lamerdin, J.E., Tucker, J.D., Zhou, Z.Q., Walter, C.A., Albala, J.S., Busch, D.B., Thompson, L.H. Proc. Natl. Acad. Sci. U.S.A. (1997)
- The fanconi anemia proteins FANCA and FANCG stabilize each other and promote the nuclear accumulation of the Fanconi anemia complex. Garcia-Higuera, I., Kuang, Y., Denham, J., D'Andrea, A.D. Blood (2000)
- Functional analysis of patient-derived mutations in the Fanconi anemia gene, FANCG/XRCC9. Nakanishi, K., Moran, A., Hays, T., Kuang, Y., Fox, E., Garneau, D., de Oca, R.M., Grompe, M., D'Andrea, A.D. Exp. Hematol. (2001)
- The Chinese hamster FANCG/XRCC9 mutant NM3 fails to express the monoubiquitinated form of the FANCD2 protein, is hypersensitive to a range of DNA damaging agents and exhibits a normal level of spontaneous sister chromatid exchange. Wilson, J.B., Johnson, M.A., Stuckert, A.P., Trueman, K.L., May, S., Bryant, P.E., Meyn, R.E., D'Andrea, A.D., Jones, N.J. Carcinogenesis (2001)
- Four human FANCG polymorphic variants show normal biological function in hamster CHO cells. Hinz, J.M., Nham, P.B., Yamada, N.A., Tebbs, R.S., Salazar, E.P., Hinz, A.K., Mohrenweiser, H.W., Jones, I.M., Thompson, L.H. Mutat. Res. (2006)
- Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells. Yamamoto, K., Ishiai, M., Matsushita, N., Arakawa, H., Lamerdin, J.E., Buerstedde, J.M., Tanimoto, M., Harada, M., Thompson, L.H., Takata, M. Mol. Cell. Biol. (2003)
- Germ line Fanconi anemia complementation group C mutations and pancreatic cancer. Couch, F.J., Johnson, M.R., Rabe, K., Boardman, L., McWilliams, R., de Andrade, M., Petersen, G. Cancer Res. (2005)
- Resistance to mitomycin C requires direct interaction between the Fanconi anemia proteins FANCA and FANCG in the nucleus through an arginine-rich domain. Kruyt, F.A., Abou-Zahr, F., Mok, H., Youssoufian, H. J. Biol. Chem. (1999)
- Identification of multiple nuclear export sequences in Fanconi anemia group A protein that contribute to CRM1-dependent nuclear export. Ferrer, M., Rodríguez, J.A., Spierings, E.A., de Winter, J.P., Giaccone, G., Kruyt, F.A. Hum. Mol. Genet. (2005)
- FANCG is phosphorylated at serines 383 and 387 during mitosis. Mi, J., Qiao, F., Wilson, J.B., High, A.A., Schroeder, M.J., Stukenberg, P.T., Moss, A., Shabanowitz, J., Hunt, D.F., Jones, N.J., Kupfer, G.M. Mol. Cell. Biol. (2004)
- Oxidative stress/damage induces multimerization and interaction of Fanconi anemia proteins. Park, S.J., Ciccone, S.L., Beck, B.D., Hwang, B., Freie, B., Clapp, D.W., Lee, S.H. J. Biol. Chem. (2004)
- Human alpha spectrin II and the FANCA, FANCC, and FANCG proteins bind to DNA containing psoralen interstrand cross-links. McMahon, L.W., Sangerman, J., Goodman, S.R., Kumaresan, K., Lambert, M.W. Biochemistry (2001)
- Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems. Gordon, S.M., Buchwald, M. Blood (2003)
- Direct interaction of the Fanconi anaemia protein FANCG with BRCA2/FANCD1. Hussain, S., Witt, E., Huber, P.A., Medhurst, A.L., Ashworth, A., Mathew, C.G. Hum. Mol. Genet. (2003)
- The Fanconi anemia gene product FANCF is a flexible adaptor protein. Léveillé, F., Blom, E., Medhurst, A.L., Bier, P., Laghmani, e.l. .H., Johnson, M., Rooimans, M.A., Sobeck, A., Waisfisz, Q., Arwert, F., Patel, K.J., Hoatlin, M.E., Joenje, H., de Winter, J.P. J. Biol. Chem. (2004)
- The FANCG Fanconi anemia protein interacts with CYP2E1: possible role in protection against oxidative DNA damage. Futaki, M., Igarashi, T., Watanabe, S., Kajigaya, S., Tatsuguchi, A., Wang, J., Liu, J.M. Carcinogenesis (2002)
- Tetratricopeptide-motif-mediated interaction of FANCG with recombination proteins XRCC3 and BRCA2. Hussain, S., Wilson, J.B., Blom, E., Thompson, L.H., Sung, P., Gordon, S.M., Kupfer, G.M., Joenje, H., Mathew, C.G., Jones, N.J. DNA Repair (Amst.) (2006)
- Investigation of Fanconi anemia protein interactions by yeast two-hybrid analysis. Huber, P.A., Medhurst, A.L., Youssoufian, H., Mathew, C.G. Biochem. Biophys. Res. Commun. (2000)
- Fanconi anemia protein, FANCG, is a phosphoprotein and is upregulated with FANCA after TNF-alpha treatment. Futaki, M., Watanabe, S., Kajigaya, S., Liu, J.M. Biochem. Biophys. Res. Commun. (2001)
- Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex. Garcia-Higuera, I., Kuang, Y., Näf, D., Wasik, J., D'Andrea, A.D. Mol. Cell. Biol. (1999)
- Spectrum and significance of variants and mutations in the Fanconi anaemia group G gene in children with sporadic acute myeloid leukaemia. Meyer, S., Barber, L.M., White, D.J., Will, A.M., Birch, J.M., Kohler, J.A., Ersfeld, K., Blom, E., Joenje, H., Eden, T.O., Malcolm Taylor, G. Br. J. Haematol. (2006)
- Molecular characterization of three novel Fanconi anemia mutations in Israeli Arabs. Tamary, H., Dgany, O., Toledano, H., Shalev, Z., Krasnov, T., Shalmon, L., Schechter, T., Bercovich, D., Attias, D., Laor, R., Koren, A., Yaniv, I. Eur. J. Haematol. (2004)