Gene Review:
Tlr4 - toll-like receptor 4
Mus musculus
Synonyms:
Lps, Ly87, Ran/M1, Rasl2-8, Toll-like receptor 4, ...
Tsatsanis,
Androulidaki,
Alissafi,
Charalampopoulos,
Dermitzaki,
Roger,
Gravanis,
Margioris,
Huang,
Du,
McClellan,
Barrett,
Hazlett,
Mizel,
Honko,
Moors,
Smith,
West,
Yohe,
O'Hara,
Hunt,
Kitzmiller,
Wood,
Bement,
Bement,
Szakacs,
Wrighton,
Jacobs,
Kostrubsky,
Sinclair,
Sinclair,
Chapes,
Mosier,
Wright,
Hart,
Uesugi,
Froh,
Arteel,
Bradford,
Thurman,
Leibovich,
Chen,
Pinhal-Enfield,
Belem,
Elson,
Rosania,
Ramanathan,
Montesinos,
Jacobson,
Schwarzschild,
Fink,
Cronstein,
Bauer,
Dixon,
DeGraff,
Cho,
Walker,
Malkinson,
Kleeberger,
Darville,
O'Neill,
Andrews,
Nagarajan,
Stahl,
Ojcius,
Tsan,
Clark,
Goyert,
White,
Song,
Shi,
Ao,
Harken,
Meng,
- Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Poltorak, A., He, X., Smirnova, I., Liu, M.Y., Van Huffel, C., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., Layton, B., Beutler, B. Science (1998)
- Monoallelic expression of the murine gene encoding Toll-like receptor 4. Pereira, J.P., Girard, R., Chaby, R., Cumano, A., Vieira, P. Nat. Immunol. (2003)
- Overexpression of Toll-like receptor 4 amplifies the host response to lipopolysaccharide and provides a survival advantage in transgenic mice. Bihl, F., Salez, L., Beaubier, M., Torres, D., Larivière, L., Laroche, L., Benedetto, A., Martel, D., Lapointe, J.M., Ryffel, B., Malo, D. J. Immunol. (2003)
- Protective immunity to the larval stages of onchocerca volvulus is dependent on Toll-like receptor 4. Kerepesi, L.A., Leon, O., Lustigman, S., Abraham, D. Infect. Immun. (2005)
- MHCII, Tlr4 and Nramp1 genes control host pulmonary resistance against the opportunistic bacterium Pasteurella pneumotropica. Chapes, S.K., Mosier, D.A., Wright, A.D., Hart, M.L. J. Leukoc. Biol. (2001)
- Down-regulation of mouse organic anion-transporting polypeptide 4 (Oatp4; Oatp1b2; Slc21a10) mRNA by lipopolysaccharide through the toll-like receptor 4 (TLR4). Li, N., Choudhuri, S., Cherrington, N.J., Klaassen, C.D. Drug Metab. Dispos. (2004)
- C5a negatively regulates toll-like receptor 4-induced immune responses. Hawlisch, H., Belkaid, Y., Baelder, R., Hildeman, D., Gerard, C., Köhl, J. Immunity (2005)
- ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses. Papoutsopoulou, S., Symons, A., Tharmalingham, T., Belich, M.P., Kaiser, F., Kioussis, D., O'Garra, A., Tybulewicz, V., Ley, S.C. Nat. Immunol. (2006)
- Differential roles of CD14 and toll-like receptors 4 and 2 in murine Acinetobacter pneumonia. Knapp, S., Wieland, C.W., Florquin, S., Pantophlet, R., Dijkshoorn, L., Tshimbalanga, N., Akira, S., van der Poll, T. Am. J. Respir. Crit. Care Med. (2006)
- Bacterially-induced preterm labor and regulation of prostaglandin-metabolizing enzyme expression in mice: the role of toll-like receptor 4. Wang, H., Hirsch, E. Biol. Reprod. (2003)
- Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. Raetz, C.R., Garrett, T.A., Reynolds, C.M., Shaw, W.A., Moore, J.D., Smith, D.C., Ribeiro, A.A., Murphy, R.C., Ulevitch, R.J., Fearns, C., Reichart, D., Glass, C.K., Benner, C., Subramaniam, S., Harkewicz, R., Bowers-Gentry, R.C., Buczynski, M.W., Cooper, J.A., Deems, R.A., Dennis, E.A. J. Lipid Res. (2006)
- Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity. Yohe, H.C., O'Hara, K.A., Hunt, J.A., Kitzmiller, T.J., Wood, S.G., Bement, J.L., Bement, W.J., Szakacs, J.G., Wrighton, S.A., Jacobs, J.M., Kostrubsky, V., Sinclair, P.R., Sinclair, J.F. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)
- Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines. Chakravarty, S., Herkenham, M. J. Neurosci. (2005)
- Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). Qureshi, S.T., Larivière, L., Leveque, G., Clermont, S., Moore, K.J., Gros, P., Malo, D. J. Exp. Med. (1999)
- Corticotropin-releasing factor and the urocortins induce the expression of TLR4 in macrophages via activation of the transcription factors PU.1 and AP-1. Tsatsanis, C., Androulidaki, A., Alissafi, T., Charalampopoulos, I., Dermitzaki, E., Roger, T., Gravanis, A., Margioris, A.N. J. Immunol. (2006)
- Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin. Leibovich, S.J., Chen, J.F., Pinhal-Enfield, G., Belem, P.C., Elson, G., Rosania, A., Ramanathan, M., Montesinos, C., Jacobson, M., Schwarzschild, M.A., Fink, J.S., Cronstein, B. Am. J. Pathol. (2002)
- A role for Toll-like receptor 4 in dendritic cell activation and cytolytic CD8+ T cell differentiation in response to a recombinant heat shock fusion protein. Palliser, D., Huang, Q., Hacohen, N., Lamontagne, S.P., Guillen, E., Young, R.A., Eisen, H.N. J. Immunol. (2004)
- Mouse paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria. Tanabe, H., Ayabe, T., Bainbridge, B., Guina, T., Ernst, R.K., Darveau, R.P., Miller, S.I., Ouellette, A.J. Infect. Immun. (2005)
- Induction of TNF-alpha and MnSOD by endotoxin: role of membrane CD14 and Toll-like receptor-4. Tsan, M.F., Clark, R.N., Goyert, S.M., White, J.E. Am. J. Physiol., Cell Physiol. (2001)
- Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis. Bauer, A.K., Dixon, D., DeGraff, L.M., Cho, H.Y., Walker, C.R., Malkinson, A.M., Kleeberger, S.R. J. Natl. Cancer Inst. (2005)
- Toll-like receptor 4 is involved in outward arterial remodeling. Hollestelle, S.C., De Vries, M.R., Van Keulen, J.K., Schoneveld, A.H., Vink, A., Strijder, C.F., Van Middelaar, B.J., Pasterkamp, G., Quax, P.H., De Kleijn, D.P. Circulation (2004)
- The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4. Lee, J.Y., Lowell, C.A., Lemay, D.G., Youn, H.S., Rhee, S.H., Sohn, K.H., Jang, B., Ye, J., Chung, J.H., Hwang, D.H. Biochem. Pharmacol. (2005)
- Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Uesugi, T., Froh, M., Arteel, G.E., Bradford, B.U., Thurman, R.G. Hepatology (2001)
- Defective ceramide response in C3H/HeJ (Lpsd) macrophages. Barber, S.A., Perera, P.Y., Vogel, S.N. J. Immunol. (1995)
- The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages. Cao, X., Wei, G., Fang, H., Guo, J., Weinstein, M., Marsh, C.B., Ostrowski, M.C., Tridandapani, S. J. Immunol. (2004)
- Toll-like receptor 4 mediates tolerance in macrophages stimulated with Toxoplasma gondii-derived heat shock protein 70. Mun, H.S., Aosai, F., Norose, K., Piao, L.X., Fang, H., Akira, S., Yano, A. Infect. Immun. (2005)
- Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes. Mizel, S.B., Honko, A.N., Moors, M.A., Smith, P.S., West, A.P. J. Immunol. (2003)
- Inducible binding of PU.1 and interacting proteins to the Toll-like receptor 4 promoter during endotoxemia. Pedchenko, T.V., Park, G.Y., Joo, M., Blackwell, T.S., Christman, J.W. Am. J. Physiol. Lung Cell Mol. Physiol. (2005)
- Toxoplasma gondii inhibits toll-like receptor 4 ligand-induced mobilization of intracellular tumor necrosis factor alpha to the surface of mouse peritoneal neutrophils. Bennouna, S., Sukhumavasi, W., Denkers, E.Y. Infect. Immun. (2006)
- TLR4 mediates LPS-induced HO-1 expression in mouse liver: role of TNF-alpha and IL-1beta. Song, Y., Shi, Y., Ao, L.H., Harken, A.H., Meng, X.Z. World J. Gastroenterol. (2003)
- Preterm delivery induced by LPS in syngeneically impregnated BALB/c and NOD/SCID mice. Lin, Y., Xie, M., Chen, Y., Di, J., Zeng, Y. J. Reprod. Immunol. (2006)
- Differential expression and regulation of macrophage inflammatory protein (MIP)-1alpha and MIP-2 genes by alveolar and peritoneal macrophages in LPS-hyporesponsive C3H/HeJ mice. Wang, M.J., Jeng, K.C., Shih, P.C. Cell. Immunol. (2000)
- Lipopolysaccharide-induced down-regulation of organic anion transporting polypeptide 4 (Oatp4; Slc21a10) is independent of tumor necrosis factor-alpha, Interleukin-1beta, interleukin-6, or inducible nitric oxide synthase. Li, N., Klaassen, C.D. Toxicol. Sci. (2005)
- ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Matsuzawa, A., Saegusa, K., Noguchi, T., Sadamitsu, C., Nishitoh, H., Nagai, S., Koyasu, S., Matsumoto, K., Takeda, K., Ichijo, H. Nat. Immunol. (2005)
- Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism. An, H., Xu, H., Zhang, M., Zhou, J., Feng, T., Qian, C., Qi, R., Cao, X. Blood (2005)
- Endogenous interleukin-6, but not tumor necrosis factor alpha, contributes to the development of toll-like receptor 4/myeloid differentiation factor 88-mediated acute arthritis in mice. Kyo, F., Futani, H., Matsui, K., Terada, M., Adachi, K., Nagata, K., Sano, H., Tateishi, H., Tsutsui, H., Nakanishi, K. Arthritis Rheum. (2005)
- Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. Asehnoune, K., Strassheim, D., Mitra, S., Kim, J.Y., Abraham, E. J. Immunol. (2004)
- Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection. Darville, T., O'Neill, J.M., Andrews, C.W., Nagarajan, U.M., Stahl, L., Ojcius, D.M. J. Immunol. (2003)
- Interleukin 13 gene transfer in liver ischemia and reperfusion injury: role of Stat6 and TLR4 pathways in cytoprotection. Ke, B., Shen, X.D., Gao, F., Busuttil, R.W., Kupiec-Weglinski, J.W. Hum. Gene Ther. (2004)
- TLR4 Is Required for Host Resistance in Pseudomonas aeruginosa Keratitis. Huang, X., Du, W., McClellan, S.A., Barrett, R.P., Hazlett, L.D. Invest. Ophthalmol. Vis. Sci. (2006)