The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

FAU  -  Finkel-Biskis-Reilly murine sarcoma virus...

Homo sapiens

Synonyms: FAU1, FLJ22986, Fub1, Fubi, MNSFbeta, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of FAU

  • The FAU gene is the cellular homologue of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) [1].
  • Exclusion of FAU as the multiple endocrine neoplasia type 1 (MEN1) gene [2].
  • Two cell lines, U-937 and MOLT-4, were used to investigate the toxicity, DNA incorporation, and effect on mitochondria of 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) and its putative metabolite 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)-uracil (FAU) [3].
  • Furthermore, we identified a t(11;17)(q13;q21) translocation in tumor cells of a t(11;14)(q13;q32)-positive B-cell non-Hodgkin's lymphoma patient by FISH analysis using a FAU containing cosmid clone as molecular probe and by double-colour chromosome painting analysis using chromosome 11- and chromosome 17-specific painting probes [4].
  • In our effort to characterize a gene at chromosome 11q13 involved in a t(11;17)(q13;q21) translocation in B-non-Hodgkin lymphoma, we have identified a novel human gene, NOF (Neighbour of FAU) [5].
 

High impact information on FAU

  • We conclude that FAU is not likely to be the MEN1 tumour suppressor gene [2].
  • The human FAU gene maps to the long arm of chromosome 11 band q13, close to the PYGM locus [2].
  • At lower levels of fusion the dose response was found to be based on the same simple kinetic rules in all cell lines and was defined by the formula: t = FS . FAU/(I + FS . FAU), where FS (fusion sensitivity) is a cell-specific constant of the fusion rate and FAU (fusion activity units) is the virus dose [6].
  • These data negate several possible mechanisms (DNA chain termination, DNA polymerase inhibition, one form of selective mitochondrial poisoning, and FAU-mediated toxicity) and provide clues for possible mechanisms (FIAU triphosphate concentration and DNA incorporation) [3].
  • Affinity index (AT value), adsorption heat, X-ray diffraction (XRD), and 13C and 29Si magic-angle spinning (MAS) NMR, FTIR, and Raman spectroscopies were used to study the interaction of highly siliceous MFI-, FAU-, and FER-type zeolites with adsorbed methylamine (MA) [7].
 

Biological context of FAU

 

Anatomical context of FAU

  • FAU was then further mapped, both on a panel of radiation-reduced somatic cell hybrids designed to carry different parts of the 11q13 region and by pulsed-field gel electrophoresis [1].
  • FAU-type zeolite membranes were synthesized by the vapor phase transformation (VPT) methods with or without prior seeding on the substrate, and it was revealed that the CO(2)/N(2) selectivity of the seeded membrane is greater than that of the unseeded membrane [8].
  • The increased retention of FAU in the breast compared to bone marrow indicates that FAU may be useful as an unlabeled antineoplastic agent [9].
 

Associations of FAU with chemical compounds

  • PURPOSE: FAU (1-(2'-deoxy-2'-fluoro-beta-D: -arabinofuranosyl) uracil) can be phosphorylated by thymidine kinase, methylated by thymidylate synthase, followed by DNA incorporation and thus functions as a DNA synthesis inhibitor [9].
  • Cu(II) is most easily reduced in siliceous FAU, but the reduction proceeds in two clearly separated steps [10].
  • In situ incorporation of 2-(2-hydroxyphenyl)benzothiazole within FAU colloidal crystals [11].
  • Comment on "Synthesis of Fully Dehydrated Fully Zn(2+)-Exchanged Zeolite Y and Its Crystal Structure Determined by Pulsed-Neutron Diffraction". Cationic Zinc Clusters Formally Containing Zn(I) in the Sodalite Cavities of Zeolite Y (FAU) [12].
  • Crystal structure of an ethylene sorption complex of fully vacuum-dehydrated fully Ag+-exchanged zeolite X (FAU). Silver atoms have reduced ethylene to give CH2 2- carbanions at framework oxide vacancies [13].
 

Other interactions of FAU

  • The two breakpoints appear distinct from the two previously described ones which involved the FAU and GSTP1 genes [14].
  • FAU1P exhibits an amplification of the (AAG) triplet repeat present in the S30 coding part of FAU [15].
  • The extraframework cation sites located in the vicinity of the double six-member rings (D6R) of FAU zeolites (SI, SI', SIII') were considered and clusters with composition (M(n)(+))(2/)(n)()H(12)Si(10)Al(2)O(18), M = Li(+), Na(+), K(+), Ca(2+), were selected to represent the adsorption centers [16].
  • The reduction of Cu(II) oxide species in siliceous matrixes of different porosity (MFI, FAU, MCM-48) and in alumosilicate MFI was studied by temperature-programmed reduction in hydrogen (TPR), by X-ray absorption fine structure (after stationary hydrogen treatments), and by transmission electron microscopy [17].
 

Analytical, diagnostic and therapeutic context of FAU

  • To test this hypothesis we screened 33 unrelated patients with MEN1 for constitutional genetic alterations in the FAU gene by Southern blot analysis, denaturing gradient gel electrophoresis (DGGE) and in two cases complemented by DNA sequencing to confirm the DGGE data [2].
  • In addition, we studied the expression of the FAU gene at the RNA level in 9 MEN1-associated tumours by Northern blot analysis [2].
  • The force field reproduces the sodium positions in dehydrated FAU-type zeolites known from crystallography, and it predicts how the sodium cations redistribute when n-alkanes adsorb [18].
  • The hydrogen/deuterium exchange reaction of 2,2-dimethylpropane (neopentane) over D(2)O-exchanged zeolites (MOR, FAU, BEA, MFI) using a batch recirculation reactor was studied by means of gas chromatography coupled with mass spectrometer [19].

References

  1. Assignment of the human FAU gene to a subregion of chromosome 11q13. Kas, K., Schoenmakers, E., van de Ven, W., Weber, G., Nordenskjöld, M., Michiels, L., Merregaert, J., Larsson, C. Genomics (1993) [Pubmed]
  2. Exclusion of FAU as the multiple endocrine neoplasia type 1 (MEN1) gene. Kas, K., Weber, G., Merregaert, J., Michiels, L., Sandelin, K., Skogseid, B., Thompson, N., Nordenskjöld, M., Larsson, C., Friedman, E. Hum. Mol. Genet. (1993) [Pubmed]
  3. Toxicity, metabolism, DNA incorporation with lack of repair, and lactate production for 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)-5-iodouracil in U-937 and MOLT-4 cells. Klecker, R.W., Katki, A.G., Collins, J.M. Mol. Pharmacol. (1994) [Pubmed]
  4. Molecular mapping of the chromosome 11 breakpoint of t(11;17)(q13;q21) in a t(11;14)(q13;q32)-positive B non-Hodgkin's lymphoma. Wlodarska, I., Schoenmakers, E., Kas, K., Merregaert, J., Lemahieu, V., Weier, U., Van den Berghe, H., Van de Ven, W.J. Genes Chromosomes Cancer (1993) [Pubmed]
  5. Isolation, cDNA, and genomic structure of a conserved gene (NOF) at chromosome 11q13 next to FAU and oriented in the opposite transcriptional orientation. Kas, K., Lemahieu, V., Meyen, E., Van de Ven, W.J., Merregaert, J. Genomics (1996) [Pubmed]
  6. Quantitative cell fusion: the fusion sensitivity (FS) potential. Röhme, D. J. Cell. Sci. (1981) [Pubmed]
  7. The leading role of association in framework modification of highly siliceous zeolites with adsorbed methylamine. Han, A.J., Guo, J., Yu, H., Zeng, Y., Huang, Y.F., He, H.Y., Long, Y.C. Chemphyschem : a European journal of chemical physics and physical chemistry. (2006) [Pubmed]
  8. Novel synthesis of FAU-type zeolite membrane with high performance. Cheng, Z., Gao, E., Wan, H. Chem. Commun. (Camb.) (2004) [Pubmed]
  9. Imaging the pharmacokinetics of [F-18]FAU in patients with tumors: PET studies. Sun, H., Collins, J.M., Mangner, T.J., Muzik, O., Shields, A.F. Cancer Chemother. Pharmacol. (2006) [Pubmed]
  10. The reduction of copper in porous matrices--the role of electrostatic stabilisation. Tkachenko, O.P., Klementiev, K.V., van den Berg, M.W., Gies, H., Grünert, W. Physical chemistry chemical physics : PCCP. (2006) [Pubmed]
  11. In situ incorporation of 2-(2-hydroxyphenyl)benzothiazole within FAU colloidal crystals. Mintova, S., De Waele, V., Schmidhammer, U., Riedle, E., Bein, T. Angew. Chem. Int. Ed. Engl. (2003) [Pubmed]
  12. Comment on "Synthesis of Fully Dehydrated Fully Zn(2+)-Exchanged Zeolite Y and Its Crystal Structure Determined by Pulsed-Neutron Diffraction". Cationic Zinc Clusters Formally Containing Zn(I) in the Sodalite Cavities of Zeolite Y (FAU). Seff, K. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2005) [Pubmed]
  13. Crystal structure of an ethylene sorption complex of fully vacuum-dehydrated fully Ag+-exchanged zeolite X (FAU). Silver atoms have reduced ethylene to give CH2 2- carbanions at framework oxide vacancies. Lee, Y.M., Choi, S.J., Kim, Y., Seff, K. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2005) [Pubmed]
  14. Rearrangement of proximal 11q13 band in a CMML in acute transformation. Courseaux, A., Grosgeorge, J., Garnier, G., Larsson, C., Ayraud, N., Gaudray, P., Raynaud, S.D. Leukemia (1995) [Pubmed]
  15. Characterization of a processed pseudogene of human FAU1 on chromosome 18. Kas, K., Stickens, D., Merregaert, J. Gene (1995) [Pubmed]
  16. Interaction of molecular nitrogen and oxygen with extraframework cations in zeolites with double six-membered rings of oxygen-bridged silicon and aluminum atoms: a DFT study. Mikosch, H., Uzunova, E.L., St Nikolov, G. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2005) [Pubmed]
  17. Reduction of copper in porous matrixes. Stepwise and autocatalytic reduction routes. Tkachenko, O.P., Klementiev, K.V., van den Berg, M.W., Koc, N., Bandyopadhyay, M., Birkner, A., Wöll, C., Gies, H., Grünert, W. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2005) [Pubmed]
  18. Understanding the role of sodium during adsorption: a force field for alkanes in sodium-exchanged faujasites. Calero, S., Dubbeldam, D., Krishna, R., Smit, B., Vlugt, T.J., Denayer, J.F., Martens, J.A., Maesen, T.L. J. Am. Chem. Soc. (2004) [Pubmed]
  19. Neopentane and Solid Acids: Direct Hydron Exchange before Cracking. Walspurger, S., Sun, Y., Souna Sido, A.S., Sommer, J. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2006) [Pubmed]
 
WikiGenes - Universities