Gene Review:
Tnfrsf4 - tumor necrosis factor receptor superfamily...
Mus musculus
Synonyms:
ACT35, CD134, Ly-70, OX40 antigen, OX40L receptor, ...
- OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation. Salek-Ardakani, S., Song, J., Halteman, B.S., Jember, A.G., Akiba, H., Yagita, H., Croft, M. J. Exp. Med. (2003)
- OX40 ligation on activated T cells enhances the control of Cryptococcus neoformans and reduces pulmonary eosinophilia. Humphreys, I.R., Edwards, L., Walzl, G., Rae, A.J., Dougan, G., Hill, S., Hussell, T. J. Immunol. (2003)
- Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40. Jember, A.G., Zuberi, R., Liu, F.T., Croft, M. J. Exp. Med. (2001)
- Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40). Pippig, S.D., Peña-Rossi, C., Long, J., Godfrey, W.R., Fowell, D.J., Reiner, S.L., Birkeland, M.L., Locksley, R.M., Barclay, A.N., Killeen, N. J. Immunol. (1999)
- Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. Song, J., So, T., Cheng, M., Tang, X., Croft, M. Immunity (2005)
- CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells. Kim, M.Y., Gaspal, F.M., Wiggett, H.E., McConnell, F.M., Gulbranson-Judge, A., Raykundalia, C., Walker, L.S., Goodall, M.D., Lane, P.J. Immunity (2003)
- The costimulation-regulated duration of PKB activation controls T cell longevity. Song, J., Salek-Ardakani, S., Rogers, P.R., Cheng, M., Van Parijs, L., Croft, M. Nat. Immunol. (2004)
- OX40/OX40L interaction induces the expression of CXCR5 and contributes to chronic colitis induced by dextran sulfate sodium in mice. Obermeier, F., Schwarz, H., Dunger, N., Strauch, U.G., Grunwald, N., Schölmerich, J., Falk, W. Eur. J. Immunol. (2003)
- Critical, but conditional, role of OX40 in memory T cell-mediated rejection. Vu, M.D., Clarkson, M.R., Yagita, H., Turka, L.A., Sayegh, M.H., Li, X.C. J. Immunol. (2006)
- Affinity and kinetics of the interaction between soluble trimeric OX40 ligand, a member of the tumor necrosis factor superfamily, and its receptor OX40 on activated T cells. Al-Shamkhani, A., Mallett, S., Brown, M.H., James, W., Barclay, A.N. J. Biol. Chem. (1997)
- Engagement of OX40 enhances antigen-specific CD4(+) T cell mobilization/memory development and humoral immunity: comparison of alphaOX-40 with alphaCTLA-4. Evans, D.E., Prell, R.A., Thalhofer, C.J., Hurwitz, A.A., Weinberg, A.D. J. Immunol. (2001)
- A signal through OX40 (CD134) allows anergic, autoreactive T cells to acquire effector cell functions. Lathrop, S.K., Huddleston, C.A., Dullforce, P.A., Montfort, M.J., Weinberg, A.D., Parker, D.C. J. Immunol. (2004)
- Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells. Takeda, I., Ine, S., Killeen, N., Ndhlovu, L.C., Murata, K., Satomi, S., Sugamura, K., Ishii, N. J. Immunol. (2004)
- CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1. Flynn, S., Toellner, K.M., Raykundalia, C., Goodall, M., Lane, P. J. Exp. Med. (1998)
- OX40 signals during priming on dendritic cells inhibit CD4 T cell proliferation: IL-4 switches off OX40 signals enabling rapid proliferation of Th2 effectors. Kim, M.Y., Bekiaris, V., McConnell, F.M., Gaspal, F.M., Raykundalia, C., Lane, P.J. J. Immunol. (2005)
- IL-18 bridges innate and adaptive immunity through IFN-gamma and the CD134 pathway. Maxwell, J.R., Yadav, R., Rossi, R.J., Ruby, C.E., Weinberg, A.D., Aguila, H.L., Vella, A.T. J. Immunol. (2006)
- The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response. Stüber, E., Strober, W. J. Exp. Med. (1996)
- Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR. Valzasina, B., Guiducci, C., Dislich, H., Killeen, N., Weinberg, A.D., Colombo, M.P. Blood (2005)
- Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses. Gramaglia, I., Weinberg, A.D., Lemon, M., Croft, M. J. Immunol. (1998)
- Different costimulatory and growth factor requirements for CD4+ and CD8+ T cell-mediated rejection. Vu, M.D., Amanullah, F., Li, Y., Demirci, G., Sayegh, M.H., Li, X.C. J. Immunol. (2004)
- Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand. Murata, K., Ishii, N., Takano, H., Miura, S., Ndhlovu, L.C., Nose, M., Noda, T., Sugamura, K. J. Exp. Med. (2000)
- 4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses. Dawicki, W., Bertram, E.M., Sharpe, A.H., Watts, T.H. J. Immunol. (2004)
- During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion. Hendriks, J., Xiao, Y., Rossen, J.W., van der Sluijs, K.F., Sugamura, K., Ishii, N., Borst, J. J. Immunol. (2005)
- Critical role of OX40 in CD28 and CD154-independent rejection. Demirci, G., Amanullah, F., Kewalaramani, R., Yagita, H., Strom, T.B., Sayegh, M.H., Li, X.C. J. Immunol. (2004)
- Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions. Calderhead, D.M., Buhlmann, J.E., van den Eertwegh, A.J., Claassen, E., Noelle, R.J., Fell, H.P. J. Immunol. (1993)
- Vaccination with dendritic cells pulsed with apoptotic tumors in combination with anti-OX40 and anti-4-1BB monoclonal antibodies induces T cell-mediated protective immunity in Her-2/neu transgenic mice. Cuadros, C., Dominguez, A.L., Lollini, P.L., Croft, M., Mittler, R.S., Borgström, P., Lustgarten, J. Int. J. Cancer (2005)
- OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand. al-Shamkhani, A., Birkeland, M.L., Puklavec, M., Brown, M.H., James, W., Barclay, A.N. Eur. J. Immunol. (1996)