Gene Review:
FCN2 - ficolin (collagen/fibrinogen domain...
Homo sapiens
Synonyms:
37 kDa elastin-binding protein, Collagen/fibrinogen domain-containing protein 2, EBP-37, FCNL, Ficolin-2, ...
Schwaeble,
Dahl,
Thiel,
Stover,
Jensenius,
Kilpatrick,
Fujita,
Matsushita,
Frederiksen,
Thiel,
Larsen,
Jensenius,
Matsushita,
Endo,
Fujita,
Matsushita,
Kuraya,
Hamasaki,
Tsujimura,
Shiraki,
Fujita,
- L-ficolin specifically binds to lipoteichoic acid, a cell wall constituent of Gram-positive bacteria, and activates the lectin pathway of complement. Lynch, N.J., Roscher, S., Hartung, T., Morath, S., Matsushita, M., Maennel, D.N., Kuraya, M., Fujita, T., Schwaeble, W.J. J. Immunol. (2004)
- A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin. Matsushita, M., Endo, Y., Taira, S., Sato, Y., Fujita, T., Ichikawa, N., Nakata, M., Mizuochi, T. J. Biol. Chem. (1996)
- L-ficolin is a pattern recognition molecule specific for acetyl groups. Krarup, A., Thiel, S., Hansen, A., Fujita, T., Jensenius, J.C. J. Biol. Chem. (2004)
- Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons. Jackson, G.R., Salecker, I., Dong, X., Yao, X., Arnheim, N., Faber, P.W., MacDonald, M.E., Zipursky, S.L. Neuron (1998)
- Structural insights into the innate immune recognition specificities of L- and H-ficolins. Garlatti, V., Belloy, N., Martin, L., Lacroix, M., Matsushita, M., Endo, Y., Fujita, T., Fontecilla-Camps, J.C., Arlaud, G.J., Thielens, N.M., Gaboriaud, C. EMBO J. (2007)
- The baculovirus antiapoptotic p35 gene also functions via an oxidant-dependent pathway. Sah, N.K., Taneja, T.K., Pathak, N., Begum, R., Athar, M., Hasnain, S.E. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2. Hummelshoj, T., Munthe-Fog, L., Madsen, H.O., Fujita, T., Matsushita, M., Garred, P. Hum. Mol. Genet. (2005)
- Opsonic function and concentration of human serum ficolin/P35. Taira, S., Kodama, N., Matsushita, M., Fujita, T. Fukushima journal of medical science. (2000)
- Baculovirus P35 inhibits the glucocorticoid-mediated pathway of cell death. Robertson, N.M., Zangrilli, J., Fernandes-Alnemri, T., Friesen, P.D., Litwack, G., Alnemri, E.S. Cancer Res. (1997)
- Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease. Matsushita, M., Endo, Y., Fujita, T. J. Immunol. (2000)
- Human M-ficolin is a secretory protein that activates the lectin complement pathway. Liu, Y., Endo, Y., Iwaki, D., Nakata, M., Matsushita, M., Wada, I., Inoue, K., Munakata, M., Fujita, T. J. Immunol. (2005)
- The mannan-binding lectin-associated serine proteases (MASPs) and MAp19: four components of the lectin pathway activation complex encoded by two genes. Schwaeble, W., Dahl, M.R., Thiel, S., Stover, C., Jensenius, J.C. Immunobiology (2002)
- Single nucleotide polymorphisms of Ficolin 2 gene in Behçet's disease. Chen, X., Katoh, Y., Nakamura, K., Oyama, N., Kaneko, F., Endo, Y., Fujita, T., Nishida, T., Mizuki, N. J. Dermatol. Sci. (2006)
- Cloning and characterization of the human lectin P35 gene and its related gene. Endo, Y., Sato, Y., Matsushita, M., Fujita, T. Genomics (1996)
- P35, an opsonic lectin of the ficolin family, in human blood from neonates, normal adults, and recurrent miscarriage patients. Kilpatrick, D.C., Fujita, T., Matsushita, M. Immunol. Lett. (1999)
- M-ficolin, an innate immune defence molecule, binds patterns of acetyl groups and activates complement. Frederiksen, P.D., Thiel, S., Larsen, C.B., Jensenius, J.C. Scand. J. Immunol. (2005)
- Localization of the mouse defense lectin ficolin B in lysosomes of activated macrophages. Runza, V.L., Hehlgans, T., Echtenacher, B., Zähringer, U., Schwaeble, W.J., Männel, D.N. J. Endotoxin Res. (2006)
- Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2. Cseh, S., Vera, L., Matsushita, M., Fujita, T., Arlaud, G.J., Thielens, N.M. J. Immunol. (2002)
- Role of L-ficolin/mannose-binding lectin-associated serine protease complexes in the opsonophagocytosis of type III group B streptococci. Aoyagi, Y., Adderson, E.E., Min, J.G., Matsushita, M., Fujita, T., Takahashi, S., Okuwaki, Y., Bohnsack, J.F. J. Immunol. (2005)
- Activation of the lectin complement pathway by H-ficolin (Hakata antigen). Matsushita, M., Kuraya, M., Hamasaki, N., Tsujimura, M., Shiraki, H., Fujita, T. J. Immunol. (2002)
- Human mannose-binding lectin and L-ficolin function as specific pattern recognition proteins in the lectin activation pathway of complement. Ma, Y.G., Cho, M.Y., Zhao, M., Park, J.W., Matsushita, M., Fujita, T., Lee, B.L. J. Biol. Chem. (2004)
- Characterization of recombinant mannan-binding lectin-associated serine protease (MASP)-3 suggests an activation mechanism different from that of MASP-1 and MASP-2. Zundel, S., Cseh, S., Lacroix, M., Dahl, M.R., Matsushita, M., Andrieu, J.P., Schwaeble, W.J., Jensenius, J.C., Fujita, T., Arlaud, G.J., Thielens, N.M. J. Immunol. (2004)
- Hucolin, a new corticosteroid-binding protein from human plasma with structural similarities to ficolins, transforming growth factor-beta 1-binding proteins. Edgar, P.F. FEBS Lett. (1995)