Gene Review:
Vegfb - vascular endothelial growth factor B
Mus musculus
Synonyms:
VEGF-B, VEGF-related factor, VRF, Vascular endothelial growth factor B, Vrf
- Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia. Bellomo, D., Headrick, J.P., Silins, G.U., Paterson, C.A., Thomas, P.S., Gartside, M., Mould, A., Cahill, M.M., Tonks, I.D., Grimmond, S.M., Townson, S., Wells, C., Little, M., Cummings, M.C., Hayward, N.K., Kay, G.F. Circ. Res. (2000)
- Vascular endothelial growth factor-B-deficient mice show impaired development of hypoxic pulmonary hypertension. Wanstall, J.C., Gambino, A., Jeffery, T.K., Cahill, M.M., Bellomo, D., Hayward, N.K., Kay, G.F. Cardiovasc. Res. (2002)
- Purification and refolding of vascular endothelial growth factor-B. Scrofani, S.D., Fabri, L.J., Xu, P., Maccarone, P., Nash, A.D. Protein Sci. (2000)
- Vegfb gene knockout mice display reduced pathology and synovial angiogenesis in both antigen-induced and collagen-induced models of arthritis. Mould, A.W., Tonks, I.D., Cahill, M.M., Pettit, A.R., Thomas, R., Hayward, N.K., Kay, G.F. Arthritis Rheum. (2003)
- Vascular endothelial growth factor B, a novel growth factor for endothelial cells. Olofsson, B., Pajusola, K., Kaipainen, A., von Euler, G., Joukov, V., Saksela, O., Orpana, A., Pettersson, R.F., Alitalo, K., Eriksson, U. Proc. Natl. Acad. Sci. U.S.A. (1996)
- p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts. Milanini, J., Viñals, F., Pouysségur, J., Pagès, G. J. Biol. Chem. (1998)
- Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform. Olofsson, B., Pajusola, K., von Euler, G., Chilov, D., Alitalo, K., Eriksson, U. J. Biol. Chem. (1996)
- Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia. Enholm, B., Paavonen, K., Ristimäki, A., Kumar, V., Gunji, Y., Klefstrom, J., Kivinen, L., Laiho, M., Olofsson, B., Joukov, V., Eriksson, U., Alitalo, K. Oncogene (1997)
- Role of vascular endothelial growth factor receptor 1 in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in mice. Molinas, C.R., Binda, M.M., Carmeliet, P., Koninckx, P.R. Fertil. Steril. (2004)
- Assignment of the mouse Vegfb gene to mouse chromosome 19 B by in situ hybridization. Gerace, L., Cirenei, N., Cappelletti, M., Petraroli, R., Sebastiani, F., Marziliano, N. Cytogenet. Cell Genet. (2001)
- Vascular endothelial growth factor-B promotes in vivo angiogenesis. Silvestre, J.S., Tamarat, R., Ebrahimian, T.G., Le-Roux, A., Clergue, M., Emmanuel, F., Duriez, M., Schwartz, B., Branellec, D., Lévy, B.I. Circ. Res. (2003)
- Extracellular matrix tenascin-X in combination with vascular endothelial growth factor B enhances endothelial cell proliferation. Ikuta, T., Ariga, H., Matsumoto, K. Genes Cells (2000)
- Analysis of the promoter region of the human VEGF-related factor gene. Silins, G., Grimmond, S., Egerton, M., Hayward, N. Biochem. Biophys. Res. Commun. (1997)
- Transgenic overexpression of vascular endothelial growth factor-B isoforms by endothelial cells potentiates postnatal vessel growth in vivo and in vitro. Mould, A.W., Greco, S.A., Cahill, M.M., Tonks, I.D., Bellomo, D., Patterson, C., Zournazi, A., Nash, A., Scotney, P., Hayward, N.K., Kay, G.F. Circ. Res. (2005)
- Increased severity of cerebral ischemic injury in vascular endothelial growth factor-B-deficient mice. Sun, Y., Jin, K., Childs, J.T., Xie, L., Mao, X.O., Greenberg, D.A. J. Cereb. Blood Flow Metab. (2004)
- Vascular endothelial growth factor-B and retinal vascular development in the mouse. Reichelt, M., Shi, S., Hayes, M., Kay, G., Batch, J., Gole, G.A., Browning, J. Clin. Experiment. Ophthalmol. (2003)
- Vascular endothelial growth factor-B (VEGFB) stimulates neurogenesis: evidence from knockout mice and growth factor administration. Sun, Y., Jin, K., Childs, J.T., Xie, L., Mao, X.O., Greenberg, D.A. Dev. Biol. (2006)
- Isoform-specific regulation of vascular endothelial growth factor (VEGF) family mRNA expression in cultured mouse brown adipocytes. Asano, A., Irie, Y., Saito, M. Mol. Cell. Endocrinol. (2001)
- Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect. Aase, K., von Euler, G., Li, X., Pontén, A., Thorén, P., Cao, R., Cao, Y., Olofsson, B., Gebre-Medhin, S., Pekny, M., Alitalo, K., Betsholtz, C., Eriksson, U. Circulation (2001)
- Role of vascular endothelial growth factor and placental growth factor in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice. Molinas, C.R., Campo, R., Dewerchin, M., Eriksson, U., Carmeliet, P., Koninckx, P.R. Fertil. Steril. (2003)
- Vascular endothelial growth factor stimulates neurite outgrowth from cerebral cortical neurons via Rho kinase signaling. Jin, K., Mao, X.O., Greenberg, D.A. J. Neurobiol. (2006)
- Localization of VEGF-B in the mouse embryo suggests a paracrine role of the growth factor in the developing vasculature. Aase, K., Lymboussaki, A., Kaipainen, A., Olofsson, B., Alitalo, K., Eriksson, U. Dev. Dyn. (1999)
- Differentiation of intracranial morphine self-administration behavior among five brain regions in mice. David, V., Cazala, P. Pharmacol. Biochem. Behav. (1994)