High impact information on BC052328

• We thus conclude that Trio is essential for late embryonic development, and that Trio functions in fetal skeletal muscle formation and in the organization of neural tissues [1].
• The proliferation of trio(-/-) secondary myoblasts appeared normal, suggesting that Trio may regulate secondary myoblast alignment or fusion. trio(-/-) embryos also displayed aberrant organization in several regions within the brain, including the hippocampal formation and olfactory bulb [1].
• The DH-GEF family member Trio is of particular interest because it is a multifunctional protein possessing two GEF domains, as well as a protein serine/threonine kinase domain, and trio-like genes in Caenorhabditis elegans and Drosophila were shown to function in neural migration and axon guidance [1].
• Solo/Trio8, a membrane-associated short isoform of Trio, modulates endosome dynamics and neurite elongation [2].

Anatomical context of BC052328

• Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos [1].

References