Gene Review:
FECH - ferrochelatase
Homo sapiens
Synonyms:
EPP, FCE, Ferrochelatase, mitochondrial, Heme synthase, Protoheme ferro-lyase
- Human gene mutations. Gene symbol: FECH. Disease: Porphyria, erythropoietic. Di Pierro, E., Moriondo, V., Cappellini, M.D. Hum. Genet. (2004)
- The penetrance of dominant erythropoietic protoporphyria is modulated by expression of wildtype FECH. Gouya, L., Puy, H., Robreau, A.M., Bourgeois, M., Lamoril, J., Da Silva, V., Grandchamp, B., Deybach, J.C. Nat. Genet. (2002)
- Inheritance in erythropoietic protoporphyria: a common wild-type ferrochelatase allelic variant with low expression accounts for clinical manifestation. Gouya, L., Puy, H., Lamoril, J., Da Silva, V., Grandchamp, B., Nordmann, Y., Deybach, J.C. Blood (1999)
- EPP masquerading as angioedema. Weston, W.L. J. Allergy Clin. Immunol. (1978)
- Clinical and bacteriological efficacy and tolerability of FCE 22891 in patients with exacerbations of chronic obstructive pulmonary disease. Boersma, W.G., Puister, S.M., van Altena, R., de Vries-Hospers, H.G., Molinari, M., Koëter, G.H. Antimicrob. Agents Chemother. (1994)
- The role of functional capacity evaluation in management of foot and ankle dysfunction. Lechner, D.E. Foot and ankle clinics. (2002)
- Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. Bloomer, J.R., Brenner, D.A., Mahoney, M.J. J. Clin. Invest. (1977)
- Mutations in the iron-sulfur cluster ligands of the human ferrochelatase lead to erythropoietic protoporphyria. Schneider-Yin, X., Gouya, L., Dorsey, M., Rüfenacht, U., Deybach, J.C., Ferreira, G.C. Blood (2000)
- In-vitro activity of the new penems FCE 22101 and FCE 24362 alone or in combination with aminoglycosides against streptococci isolated from patients with endocarditis. Dornbusch, K., Henning, C., Lindén, E. J. Antimicrob. Chemother. (1989)
- Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517). Capolongo, L., Melegaro, G., Broggini, M., Mongelli, N., Grandi, M. Br. J. Cancer (1993)
- Broad phase II and pharmacokinetic study of methoxy-morpholino doxorubicin (FCE 23762-MMRDX) in non-small-cell lung cancer, renal cancer and other solid tumour patients. Bakker, M., Droz, J.P., Hanauske, A.R., Verweij, J., van Oosterom, A.T., Groen, H.J., Pacciarini, M.A., Domenigoni, L., van Weissenbruch, F., Pianezzola, E., de Vries, E.G. Br. J. Cancer (1998)
- Synthesis and aromatase inhibition by potential metabolites of exemestane (6-methylenandrosta-1,4-diene-3,17-dione). Buzzetti, F., Di Salle, E., Longo, A., Briatico, G. Steroids (1993)
- Photosensitivity and acute liver injury in myeloproliferative disorder secondary to late-onset protoporphyria caused by deletion of a ferrochelatase gene in hematopoietic cells. Goodwin, R.G., Kell, W.J., Laidler, P., Long, C.C., Whatley, S.D., McKinley, M., Badminton, M.N., Burnett, A.K., Williams, G.T., Elder, G.H. Blood (2006)
- Molecular analysis of functional and nonfunctional genes for human ferrochelatase: isolation and characterization of a FECH pseudogene and its sublocalization on chromosome 3. Whitcombe, D.M., Albertson, D.G., Cox, T.M. Genomics (1994)
- DNA sequence-specific adenine alkylation by the novel antitumor drug tallimustine (FCE 24517), a benzoyl nitrogen mustard derivative of distamycin. Broggini, M., Coley, H.M., Mongelli, N., Pesenti, E., Wyatt, M.D., Hartley, J.A., D'Incalci, M. Nucleic Acids Res. (1995)
- Distamycins inhibit the binding of OTF-1 and NFE-1 transfactors to their conserved DNA elements. Broggini, M., Ponti, M., Ottolenghi, S., D'Incalci, M., Mongelli, N., Mantovani, R. Nucleic Acids Res. (1989)
- Pharmacokinetics of FCE 22891, a new oral penem. Saathoff, A., Lode, H., Hampel, B., Deppermann, K.M., Borner, K., Koeppe, P. Antimicrob. Agents Chemother. (1990)
- Heme synthetase deficiency in human protoporphyria. Demonstration of the defect in liver and cultured skin fibroblasts. Bonkowsky, H.L., Bloomer, J.R., Ebert, P.S., Mahoney, M.J. J. Clin. Invest. (1975)
- Biological profile of FCE 24517, a novel benzoyl mustard analogue of distamycin A. Pezzoni, G., Grandi, M., Biasoli, G., Capolongo, L., Ballinari, D., Giuliani, F.C., Barbieri, B., Pastori, A., Pesenti, E., Mongelli, N. Br. J. Cancer (1991)
- Hemoglobin synthesis in a rabbit ribosomal system: localization of heme synthetase activity. Gribble, T.J., Edmunds, D., Schwartz, H.C. Pediatr. Res. (1977)
- Comparative in vitro myelotoxicity of FCE 24517, a distamycin derivative, to human, canine and murine hematopoietic progenitor cells. Volpe, D.A., Du, D.L., Zurlo, M.G., Mongelli, N., Murphy, M.J. Investigational new drugs. (1992)
- Phase I and endocrine study of exemestane (FCE 24304), a new aromatase inhibitor, in postmenopausal women. Evans, T.R., Di Salle, E., Ornati, G., Lassus, M., Benedetti, M.S., Pianezzola, E., Coombes, R.C. Cancer Res. (1992)
- Phase I clinical and pharmacokinetic study of 3'-deamino-3'-(2-methoxy-4-morpholinyl)doxorubicin (FCE 23762). Vasey, P.A., Bissett, D., Strolin-Benedetti, M., Poggesi, I., Breda, M., Adams, L., Wilson, P., Pacciarini, M.A., Kaye, S.B., Cassidy, J. Cancer Res. (1995)
- Distamycin A and tallimustine inhibit TBP binding and basal in vitro transcription. Bellorini, M., Moncollin, V., D'Incalci, M., Mongelli, N., Mantovani, R. Nucleic Acids Res. (1995)
- Substrate interactions with human ferrochelatase. Medlock, A., Swartz, L., Dailey, T.A., Dailey, H.A., Lanzilotta, W.N. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Pharmacokinetics of [14C]FCE 22891, a penem antibiotic, following oral administration to healthy volunteers. Efthymiopoulos, C., Strolin Benedetti, M., Sassella, D., Boobis, A., Davies, D. Antimicrob. Agents Chemother. (1992)
- Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet. Thoresen, M., Penrice, J., Lorek, A., Cady, E.B., Wylezinska, M., Kirkbride, V., Cooper, C.E., Brown, G.C., Edwards, A.D., Wyatt, J.S. Pediatr. Res. (1995)